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• W4225286303 abstract "Abstract Growing evidence indicates that long intergenic noncoding RNAs play an important role in cancer progression by affecting gene regulation at the transcriptional and posttranscriptional levels. Recent studies have shown that long intergenic noncoding RNA functions as a competitive endogenous RNA, which can interact with and mitigate the function of microRNA. In this study, we investigated the molecular mechanism by which LINC00162 regulates cell proliferation and apoptotic cell death. By analyzing RNA sequencing data, LINC00162 was identified to be a target of heterogeneous nuclear ribonucleoprotein K (hnRNPK). HnRNPK positively regulated LINC00162 expression through p38 mitogen‐activated protein kinase. Lowering the level of either hnRNPK or LINC00162 decreased proliferation and colony formation while it increased apoptotic cell death. Small RNA sequencing followed by the antisense oligonucleotide pulldown, revealed that LINC00162 interacts directly with miR‐485‐5p which exhibited tumor‐suppressing effects by suppressing cell proliferation and colony formation, and increasing apoptotic cell death. Through the bioinformatic approaches, progestin and adipoQ receptor 4 (PAQR4) was selected as a common target of LINC00162 and miR‐485‐5p. miR‐485‐5p decreased the expression of PAQR4 by directly binding to the 3′‐untranslated region of PAQR4 messenger RNA. Knockdown of hnRNPK and LINC00162 increased the level of functional miR‐485‐5p, indicating that LINC00162 may compete for miR‐485‐5p, thereby derepressing PAQR4 expression. Overexpression of either hnRNPK or LINC00162 , or inhibition of miR‐485‐5p, protected cells against etoposide‐induced apoptotic death. Our findings demonstrate that a regulatory paradigm implicating hnRNPK, LINC00162 , miR‐485‐5p, and PAQR4 plays an important role in cell proliferation and apoptosis, and is a promising target for cancer therapeutics." @default.
• W4225286303 created "2022-05-05" @default.
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• W4225286303 date "2022-05-02" @default.
• W4225286303 modified "2023-10-14" @default.
• W4225286303 title "<i>LINC00162</i> regulates cell proliferation and apoptosis by sponging <i>PAQR4</i> ‐targeting miR‐485‐5p" @default.
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• W4225286303 doi "https://doi.org/10.1002/jcp.30758" @default.
• W4225286303 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35491694" @default.
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