Matches in SemOpenAlex for { <https://semopenalex.org/work/W4225287002> ?p ?o ?g. }
- W4225287002 endingPage "887.e6" @default.
- W4225287002 startingPage "874" @default.
- W4225287002 abstract "The tumor microenvironment (TME) contains a rich source of nutrients that sustains cell growth and facilitate tumor development. Glucose and glutamine in the TME are essential for the development and activation of effector T cells that exert antitumor function. Immunotherapy unleashes T cell antitumor function, and although many solid tumors respond well, a significant proportion of patients do not benefit. In patients with KRAS-mutant lung adenocarcinoma, KEAP1 and STK11/Lkb1 co-mutations are associated with impaired response to immunotherapy. To investigate the metabolic and immune microenvironment of KRAS-mutant lung adenocarcinoma, we generated murine models that reflect the KEAP1 and STK11/Lkb1 mutational landscape in these patients. Here, we show increased glutamate abundance in the Lkb1-deficient TME associated with CD8 T cell activation in response to anti-PD1. Combination treatment with the glutaminase inhibitor CB-839 inhibited clonal expansion and activation of CD8 T cells. Thus, glutaminase inhibition negatively impacts CD8 T cells activated by anti-PD1 immunotherapy." @default.
- W4225287002 created "2022-05-05" @default.
- W4225287002 creator A5001919543 @default.
- W4225287002 creator A5008276408 @default.
- W4225287002 creator A5015395050 @default.
- W4225287002 creator A5019302340 @default.
- W4225287002 creator A5020325200 @default.
- W4225287002 creator A5029645117 @default.
- W4225287002 creator A5031251128 @default.
- W4225287002 creator A5031735945 @default.
- W4225287002 creator A5044588469 @default.
- W4225287002 creator A5049270608 @default.
- W4225287002 creator A5057894753 @default.
- W4225287002 creator A5057991607 @default.
- W4225287002 creator A5063917581 @default.
- W4225287002 creator A5070581428 @default.
- W4225287002 creator A5072281936 @default.
- W4225287002 creator A5073022316 @default.
- W4225287002 creator A5076513030 @default.
- W4225287002 creator A5087940051 @default.
- W4225287002 date "2022-06-01" @default.
- W4225287002 modified "2023-10-13" @default.
- W4225287002 title "Glutaminase inhibition impairs CD8 T cell activation in STK11-/Lkb1-deficient lung cancer" @default.
- W4225287002 cites W1611854178 @default.
- W4225287002 cites W1918238463 @default.
- W4225287002 cites W1975566288 @default.
- W4225287002 cites W1975755652 @default.
- W4225287002 cites W1981851742 @default.
- W4225287002 cites W1992250154 @default.
- W4225287002 cites W1993023349 @default.
- W4225287002 cites W1994772304 @default.
- W4225287002 cites W2003398132 @default.
- W4225287002 cites W2005002977 @default.
- W4225287002 cites W2022045742 @default.
- W4225287002 cites W2025000087 @default.
- W4225287002 cites W2027146979 @default.
- W4225287002 cites W2032019019 @default.
- W4225287002 cites W2032917789 @default.
- W4225287002 cites W2043398720 @default.
- W4225287002 cites W2049553585 @default.
- W4225287002 cites W2053047691 @default.
- W4225287002 cites W2056174640 @default.
- W4225287002 cites W2079999658 @default.
- W4225287002 cites W2100039832 @default.
- W4225287002 cites W2107018762 @default.
- W4225287002 cites W2114104545 @default.
- W4225287002 cites W2114843025 @default.
- W4225287002 cites W2128771042 @default.
- W4225287002 cites W2132117833 @default.
- W4225287002 cites W2134964552 @default.
- W4225287002 cites W2137526110 @default.
- W4225287002 cites W2142415307 @default.
- W4225287002 cites W2145411470 @default.
- W4225287002 cites W2146512944 @default.
- W4225287002 cites W2149441684 @default.
- W4225287002 cites W2149917889 @default.
- W4225287002 cites W2173466127 @default.
- W4225287002 cites W2177855681 @default.
- W4225287002 cites W2180481128 @default.
- W4225287002 cites W2273119405 @default.
- W4225287002 cites W2506616866 @default.
- W4225287002 cites W2507411998 @default.
- W4225287002 cites W2513922839 @default.
- W4225287002 cites W2597182072 @default.
- W4225287002 cites W2606495925 @default.
- W4225287002 cites W2619620886 @default.
- W4225287002 cites W2758805707 @default.
- W4225287002 cites W2764232556 @default.
- W4225287002 cites W2792459030 @default.
- W4225287002 cites W2799516107 @default.
- W4225287002 cites W2802386465 @default.
- W4225287002 cites W2803664483 @default.
- W4225287002 cites W2804812017 @default.
- W4225287002 cites W2884318006 @default.
- W4225287002 cites W2897100571 @default.
- W4225287002 cites W2897815318 @default.
- W4225287002 cites W2899010137 @default.
- W4225287002 cites W2943618951 @default.
- W4225287002 cites W2950464315 @default.
- W4225287002 cites W2950781034 @default.
- W4225287002 cites W2967210753 @default.
- W4225287002 cites W2972329402 @default.
- W4225287002 cites W2978325001 @default.
- W4225287002 cites W2982602983 @default.
- W4225287002 cites W2985764787 @default.
- W4225287002 cites W3012365695 @default.
- W4225287002 cites W3017125932 @default.
- W4225287002 cites W3022743377 @default.
- W4225287002 cites W3081092387 @default.
- W4225287002 cites W3092968030 @default.
- W4225287002 cites W3094376062 @default.
- W4225287002 cites W3095289242 @default.
- W4225287002 cites W3096807174 @default.
- W4225287002 cites W3099018540 @default.
- W4225287002 cites W3108354267 @default.
- W4225287002 cites W3134037109 @default.
- W4225287002 cites W3136351248 @default.
- W4225287002 cites W3180882383 @default.