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- W4225287008 abstract "Abstract Background Triple Negative Breast Cancer(TNBC) may be a profoundly pernicious subtype about breast tumor. Because of the negative statement of estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2(HER2), it will be presently without specificity targeted treatment. Traditional Chinese Medicine(TCM) Huaier Aqueous have anti-cancer effects, yet its component of activity will be even now vague. The latest research confirms that Huaier Aqueous can cause changes in various biological functions and gradually become a systemic adjuvant chemotherapy drug for cancer, so it is used in clinical anti-tumor treatment. Methods The Wound healing and Transwell test detects the relocation and invasion of MDA-MB-231 cells. Flow cytometry detects cell cycle and apoptosis. qPCR and Western blot were used to identify the statement for MDA-MB-231 cell cycle and apoptosis proteins and genes. In vivo tumor creation and HE chemical staining were used to examine the impact about Huaier Aqueous on the burgeoning from claiming TNBC. Immunohistochemical might have been used to identify the statement of Caspase9 and CyalinD1. Tunel staining strategy detects the statement of apoptosis over TNBC tissues. The information utilization one-way ANAOV and two-way ANAOV measurable examination. Results Huaier Aqueous inhibits the burgeoning of MDA-MB-231 cells. What's more disrupts the cell cycle on S phase, thereby encouraging cell apoptosis. In addition, Huaier Aqueous inhibits the PI3K/AKT/mTOR pathway, confining the downstream molecular of the pathway. Conclusions Huaier Aqueous inhibits the proliferation and cell cycle of MDA-MB-231 cells through PI3K/AKT/mTOR pathway, and pushes apoptosis." @default.
- W4225287008 created "2022-05-05" @default.
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- W4225287008 date "2022-05-02" @default.
- W4225287008 modified "2023-09-28" @default.
- W4225287008 title "Huaier Aqueous Boosts the Apoptosis of Triple Negative Breast Cancer" @default.
- W4225287008 doi "https://doi.org/10.21203/rs.3.rs-1560181/v1" @default.
- W4225287008 hasPublicationYear "2022" @default.
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