Matches in SemOpenAlex for { <https://semopenalex.org/work/W4225287046> ?p ?o ?g. }
- W4225287046 endingPage "1898" @default.
- W4225287046 startingPage "1898" @default.
- W4225287046 abstract "Nuciferine (Nuci), the main aporphine alkaloid component in lotus leaf, was reported to reduce lipid accumulation in vitro. Herein we investigated whether Nuci prevents obesity in high fat diet (HFD)-fed mice and the underlying mechanism in liver/HepG2 hepatocytes and epididymal white adipose tissue (eWAT) /adipocytes. Male C57BL/6J mice were fed with HFD supplemented with Nuci (0.10%) for 12 weeks. We found that Nuci significantly reduced body weight and fat mass, improved glycolipid profiles, and enhanced energy expenditure in HFD-fed mice. Nuci also ameliorated hepatic steatosis and decreased the size of adipocytes. Furthermore, Nuci remarkably promoted the phosphorylation of AMPK, suppressed lipogenesis (SREBP1, FAS, ACC), promoted lipolysis (HSL, ATGL), and increased the expressions of adipokines (FGF21, ZAG) in liver and eWAT. Besides, fatty acid oxidation in liver and thermogenesis in eWAT were also activated by Nuci. Similar results were further observed at cellular level, and these beneficial effects of Nuci in cells were abolished by an effective AMPK inhibitor compound C. In conclusion, Nuci supplementation prevented HFD-induced obesity, attenuated hepatic steatosis, and reduced lipid accumulation in liver/hepatocytes and eWAT/adipocytes through regulating AMPK-mediated FAS/HSL pathway. Our findings provide novel insight into the clinical application of Nuci in treating obesity and related complications." @default.
- W4225287046 created "2022-05-05" @default.
- W4225287046 creator A5021972817 @default.
- W4225287046 creator A5041595146 @default.
- W4225287046 creator A5042656907 @default.
- W4225287046 creator A5054551633 @default.
- W4225287046 creator A5067545412 @default.
- W4225287046 creator A5068009587 @default.
- W4225287046 creator A5071304644 @default.
- W4225287046 creator A5085187324 @default.
- W4225287046 creator A5090111850 @default.
- W4225287046 date "2022-04-30" @default.
- W4225287046 modified "2023-10-14" @default.
- W4225287046 title "Distinct AMPK-Mediated FAS/HSL Pathway Is Implicated in the Alleviating Effect of Nuciferine on Obesity and Hepatic Steatosis in HFD-Fed Mice" @default.
- W4225287046 cites W1509983325 @default.
- W4225287046 cites W1969363988 @default.
- W4225287046 cites W1975588513 @default.
- W4225287046 cites W1980090058 @default.
- W4225287046 cites W1980914602 @default.
- W4225287046 cites W2011574523 @default.
- W4225287046 cites W2013576112 @default.
- W4225287046 cites W2025536516 @default.
- W4225287046 cites W2046686669 @default.
- W4225287046 cites W2068465914 @default.
- W4225287046 cites W2079482653 @default.
- W4225287046 cites W2085951097 @default.
- W4225287046 cites W2099401887 @default.
- W4225287046 cites W2107277218 @default.
- W4225287046 cites W2113653640 @default.
- W4225287046 cites W2138330280 @default.
- W4225287046 cites W2145142659 @default.
- W4225287046 cites W2192080449 @default.
- W4225287046 cites W2200889199 @default.
- W4225287046 cites W2207242414 @default.
- W4225287046 cites W2328023807 @default.
- W4225287046 cites W2463824702 @default.
- W4225287046 cites W2491324259 @default.
- W4225287046 cites W2530564279 @default.
- W4225287046 cites W2696298149 @default.
- W4225287046 cites W2766550174 @default.
- W4225287046 cites W2782158120 @default.
- W4225287046 cites W2800516331 @default.
- W4225287046 cites W2884156257 @default.
- W4225287046 cites W2898942138 @default.
- W4225287046 cites W2906748726 @default.
- W4225287046 cites W2908052005 @default.
- W4225287046 cites W2913351869 @default.
- W4225287046 cites W2944333152 @default.
- W4225287046 cites W2951849368 @default.
- W4225287046 cites W2982370215 @default.
- W4225287046 cites W3005366224 @default.
- W4225287046 cites W3020225906 @default.
- W4225287046 cites W3068552074 @default.
- W4225287046 cites W3106679068 @default.
- W4225287046 cites W3106696517 @default.
- W4225287046 cites W3108713754 @default.
- W4225287046 cites W3111490933 @default.
- W4225287046 cites W3133590568 @default.
- W4225287046 cites W3136989176 @default.
- W4225287046 cites W3161959292 @default.
- W4225287046 cites W3181517635 @default.
- W4225287046 cites W3181993040 @default.
- W4225287046 cites W3193763245 @default.
- W4225287046 cites W3199769147 @default.
- W4225287046 cites W4292001606 @default.
- W4225287046 doi "https://doi.org/10.3390/nu14091898" @default.
- W4225287046 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35565866" @default.
- W4225287046 hasPublicationYear "2022" @default.
- W4225287046 type Work @default.
- W4225287046 citedByCount "11" @default.
- W4225287046 countsByYear W42252870462022 @default.
- W4225287046 countsByYear W42252870462023 @default.
- W4225287046 crossrefType "journal-article" @default.
- W4225287046 hasAuthorship W4225287046A5021972817 @default.
- W4225287046 hasAuthorship W4225287046A5041595146 @default.
- W4225287046 hasAuthorship W4225287046A5042656907 @default.
- W4225287046 hasAuthorship W4225287046A5054551633 @default.
- W4225287046 hasAuthorship W4225287046A5067545412 @default.
- W4225287046 hasAuthorship W4225287046A5068009587 @default.
- W4225287046 hasAuthorship W4225287046A5071304644 @default.
- W4225287046 hasAuthorship W4225287046A5085187324 @default.
- W4225287046 hasAuthorship W4225287046A5090111850 @default.
- W4225287046 hasBestOaLocation W42252870461 @default.
- W4225287046 hasConcept C11960822 @default.
- W4225287046 hasConcept C126322002 @default.
- W4225287046 hasConcept C134018914 @default.
- W4225287046 hasConcept C140985366 @default.
- W4225287046 hasConcept C141359234 @default.
- W4225287046 hasConcept C151279926 @default.
- W4225287046 hasConcept C151955695 @default.
- W4225287046 hasConcept C171089720 @default.
- W4225287046 hasConcept C185592680 @default.
- W4225287046 hasConcept C194832188 @default.
- W4225287046 hasConcept C2776175330 @default.
- W4225287046 hasConcept C2778772119 @default.
- W4225287046 hasConcept C2779134260 @default.
- W4225287046 hasConcept C2780124434 @default.
- W4225287046 hasConcept C2780613262 @default.