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- W4225291196 abstract "In The Lancet Oncology, Paul Thiruchelvam and colleagues 1 Thiruchelvam PTR Leff DR Godden AR et al. Primary radiotherapy and deep inferior epigastric perforator flap reconstruction for patients with breast cancer requiring mastectomy (PRADA): a multicentre, prospective, feasibility study. Lancet Oncol. 2022; (published online April 7.)https://doi.org/10.1016/S1470-2045(22)00145-0 Summary Full Text Full Text PDF PubMed Google Scholar report the findings of a prospective study (PRADA) that evaluated the safety and feasibility of skin-sparing mastectomy with axillary surgery and immediate autologous-based deep inferior epigastric perforator (DIEP) flap reconstruction after preoperative radiotherapy for patients with breast cancer. Over a period of almost 2 years, 33 patients were enrolled at two centres in the UK. The primary endpoint was the rate of open breast wounds greater than 1 cm requiring dressing or packing at 4 weeks after surgery. Secondary outcomes included the presence of an open breast wound at 8 and 12 weeks after surgery, DIEP flap failure rate, and patient-reported satisfaction with the breast reconstruction. 1 Thiruchelvam PTR Leff DR Godden AR et al. Primary radiotherapy and deep inferior epigastric perforator flap reconstruction for patients with breast cancer requiring mastectomy (PRADA): a multicentre, prospective, feasibility study. Lancet Oncol. 2022; (published online April 7.)https://doi.org/10.1016/S1470-2045(22)00145-0 Summary Full Text Full Text PDF PubMed Google Scholar Primary radiotherapy and deep inferior epigastric perforator flap reconstruction for patients with breast cancer (PRADA): a multicentre, prospective, non-randomised, feasibility studyPreoperative radiotherapy followed by skin-sparing mastectomy and immediate DIEP flap reconstruction is feasible and technically safe, with rates of breast open wounds similar to those reported with post-mastectomy radiotherapy. A randomised trial comparing preoperative radiotherapy with post-mastectomy radiotherapy is required to precisely determine and compare surgical, oncological, and breast reconstruction outcomes, including quality of life. Full-Text PDF Open Access" @default.
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- W4225291196 date "2022-05-01" @default.
- W4225291196 modified "2023-10-18" @default.
- W4225291196 title "Proud about PRADA: radiotherapy before deep inferior epigastric perforator flap reconstruction" @default.
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- W4225291196 doi "https://doi.org/10.1016/s1470-2045(22)00195-4" @default.
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