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• W4225293217 endingPage "67" @default.
• W4225293217 startingPage "49" @default.
• W4225293217 abstract "Hemin and heme-peroxidases have been considered essential catalysts for the nitrite/hydrogen peroxide (H2O2)-mediated protein nitration in vitro, understood as one of the main pathways for protein modification in biological systems. However, the role of nitric oxide (●NO) in the heme/hemin-induced protein nitration has not been studied in-depth. This is despite its reductive nitrosylating effects following binding to hemin and the possible involvement of the reactive nitrogen species in the nitration of various functional proteins. Here, the ●NO-binding affinity of hemin has been studied along with the influence of ●NO on the internalization of hemin into MDA-MB-231 cells and the accompanying changes in the profile of intracellular nitrated proteins. Moreover, to further understand the mechanism involved, bovine serum albumin (BSA) nitration was studied after treatment with hemin and ●NO, with an investigation of the effects of pH of the reaction medium, generation of H2O2, and the oxidation of the tyrosine residues as the primary sites for the nitration. We demonstrated that hemin nitrosylation enhanced its cellular uptake and induced the one-electron oxidation and nitration of different intracellular proteins along with its ●NO-scavenging efficiency. Moreover, the hemin/NO-mediated BSA nitration was proved to be dependent on the concentration of ●NO and the pH of the reaction medium, with a vital role being played by the scavenging effects of protein for the free hemin molecules. Collectively, our results reaffirm the involvement of hemin and ●NO in the nitration mechanism, where the nitrosylation products can induce protein nitration while promoting the effects of the components of the nitrite/H2O2-mediated pathway." @default.
• W4225293217 created "2022-05-05" @default.
• W4225293217 creator A5017672961 @default.
• W4225293217 creator A5022233884 @default.
• W4225293217 creator A5027018298 @default.
• W4225293217 creator A5058048911 @default.
• W4225293217 date "2022-07-01" @default.
• W4225293217 modified "2023-10-18" @default.
• W4225293217 title "Protein nitration induced by Hemin/NO: A complementary mechanism through the catalytic functions of hemin and NO-scavenging" @default.
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• W4225293217 doi "https://doi.org/10.1016/j.niox.2022.04.005" @default.
• W4225293217 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35513288" @default.
• W4225293217 hasPublicationYear "2022" @default.

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