Matches in SemOpenAlex for { <https://semopenalex.org/work/W4225293735> ?p ?o ?g. }
- W4225293735 abstract "Alzheimer’s disease (AD) is a neurodegenerative disorder and is considered to be the most common form of dementia. This disorder is characterized by the formation of amyloid β (Aβ) plaques, neurofibrillary tangles, and alterations in synaptic function, all of which cause memory loss and behavioral disturbances. Despite the high prevalence of AD, effective therapeutic and diagnostic tools remain unavailable. MicroRNAs (miRNAs, miRs) are regulatory non-coding RNAs that target mRNAs. MiRNAs are involved in the regulation of the expressions of APP and BACE1, Aβ clearance, and the formation of neuro-fibrillary tangles. Furthermore, there are evidences that show alteration in the expression of several miRs in AD. MicroRNA is emerging as a biomarker because they have high specificity and, efficiency, and can be detected in biological fluids such as cerebrospinal fluid, tear, urine, blood. Moreover, miRNAs may be acquired and measured easily by utilizing real-time PCR, next-generation sequencing, or microarray. These techniques are cost-effective in comparison with imaging techniques such as magnetic resonance imaging, positron emission tomography. These features make miRNAs viable therapeutic as well as diagnostic tools in the treatment of AD. This review covers the regulatory function of miRNAs in AD, as well as their prospective applications as diagnostic biomarkers." @default.
- W4225293735 created "2022-05-05" @default.
- W4225293735 creator A5064783287 @default.
- W4225293735 creator A5082821007 @default.
- W4225293735 creator A5087556351 @default.
- W4225293735 date "2022-11-02" @default.
- W4225293735 modified "2023-09-26" @default.
- W4225293735 title "MicroRNAs as Future Treatment Tools and Diagnostic Biomarkers in Alzheimer’s Disease" @default.
- W4225293735 cites W1233931455 @default.
- W4225293735 cites W1481130297 @default.
- W4225293735 cites W1486176185 @default.
- W4225293735 cites W1521541385 @default.
- W4225293735 cites W1634153319 @default.
- W4225293735 cites W1707484694 @default.
- W4225293735 cites W1804923980 @default.
- W4225293735 cites W1920972969 @default.
- W4225293735 cites W1967013325 @default.
- W4225293735 cites W1974660276 @default.
- W4225293735 cites W1976443246 @default.
- W4225293735 cites W1979614498 @default.
- W4225293735 cites W1980350117 @default.
- W4225293735 cites W1987829395 @default.
- W4225293735 cites W1991334828 @default.
- W4225293735 cites W1993576110 @default.
- W4225293735 cites W1998140650 @default.
- W4225293735 cites W1998440070 @default.
- W4225293735 cites W1998965915 @default.
- W4225293735 cites W2000356500 @default.
- W4225293735 cites W2001712818 @default.
- W4225293735 cites W2002636093 @default.
- W4225293735 cites W2005202312 @default.
- W4225293735 cites W2006986124 @default.
- W4225293735 cites W2014410632 @default.
- W4225293735 cites W2016811754 @default.
- W4225293735 cites W2019928888 @default.
- W4225293735 cites W2023205879 @default.
- W4225293735 cites W2025036095 @default.
- W4225293735 cites W2026439596 @default.
- W4225293735 cites W2027633665 @default.
- W4225293735 cites W2030712838 @default.
- W4225293735 cites W2034286717 @default.
- W4225293735 cites W2037414479 @default.
- W4225293735 cites W2056488510 @default.
- W4225293735 cites W2057082801 @default.
- W4225293735 cites W2059483016 @default.
- W4225293735 cites W2059994125 @default.
- W4225293735 cites W2066124024 @default.
- W4225293735 cites W2071013424 @default.
- W4225293735 cites W2072374145 @default.
- W4225293735 cites W2072484559 @default.
- W4225293735 cites W2072504660 @default.
- W4225293735 cites W2082443485 @default.
- W4225293735 cites W2084062482 @default.
- W4225293735 cites W2090196938 @default.
- W4225293735 cites W2091858036 @default.
- W4225293735 cites W2106222771 @default.
- W4225293735 cites W2111663113 @default.
- W4225293735 cites W2116365437 @default.
- W4225293735 cites W2117391623 @default.
- W4225293735 cites W2120015541 @default.
- W4225293735 cites W2120522615 @default.
- W4225293735 cites W2122320288 @default.
- W4225293735 cites W2126149232 @default.
- W4225293735 cites W2137669678 @default.
- W4225293735 cites W2141792156 @default.
- W4225293735 cites W2158545447 @default.
- W4225293735 cites W2161260889 @default.
- W4225293735 cites W2187227914 @default.
- W4225293735 cites W2206848875 @default.
- W4225293735 cites W2213477888 @default.
- W4225293735 cites W2221703732 @default.
- W4225293735 cites W2267120181 @default.
- W4225293735 cites W2279137520 @default.
- W4225293735 cites W2288482887 @default.
- W4225293735 cites W2327211142 @default.
- W4225293735 cites W2398121957 @default.
- W4225293735 cites W2402354931 @default.
- W4225293735 cites W2404161368 @default.
- W4225293735 cites W2407468727 @default.
- W4225293735 cites W2418740217 @default.
- W4225293735 cites W2433183210 @default.
- W4225293735 cites W2467883450 @default.
- W4225293735 cites W2505001531 @default.
- W4225293735 cites W2510053021 @default.
- W4225293735 cites W2562423557 @default.
- W4225293735 cites W2580678368 @default.
- W4225293735 cites W2588319218 @default.
- W4225293735 cites W2593463146 @default.
- W4225293735 cites W2704417118 @default.
- W4225293735 cites W2747870809 @default.
- W4225293735 cites W2757902459 @default.
- W4225293735 cites W2761570368 @default.
- W4225293735 cites W2775074480 @default.
- W4225293735 cites W2780107247 @default.
- W4225293735 cites W2781721887 @default.
- W4225293735 cites W2792086672 @default.
- W4225293735 cites W2794203475 @default.
- W4225293735 cites W2800151111 @default.
- W4225293735 cites W2801032454 @default.
- W4225293735 cites W2804700550 @default.