Matches in SemOpenAlex for { <https://semopenalex.org/work/W4225299069> ?p ?o ?g. }
- W4225299069 endingPage "188" @default.
- W4225299069 startingPage "181" @default.
- W4225299069 abstract "Sudden unexpected death in epilepsy (SUDEP) is a major contributor to premature mortality in people with epilepsy. This review provides an update on recent findings on the epidemiology of SUDEP, clinical risk factors and potential mechanisms.The overall risk rate of SUDEP is approximately 1 per 1000 patients per year in the general epilepsy population and that children and older adults have a similar incidence. Generalized convulsive seizures (GCS), perhaps through their effects on brainstem cardiopulmonary networks, can cause significant postictal respiratory and autonomic dysfunction though other mechanisms likely exist as well. Work in animal models of SUDEP has identified multiple neurotransmitter systems, which may be future targets for pharmacological intervention. There are also chronic functional and structural changes in autonomic function in patients who subsequently die from SUDEP suggesting that some SUDEP risk is dynamic. Modifiable risks for SUDEP include GCS seizure frequency, medication adherence and nighttime supervision.Current knowledge of SUDEP risk factors has identified multiple targets for SUDEP prevention today as we await more specific therapeutic targets that are emerging from translational research studies." @default.
- W4225299069 created "2022-05-05" @default.
- W4225299069 creator A5071565453 @default.
- W4225299069 date "2022-01-31" @default.
- W4225299069 modified "2023-10-16" @default.
- W4225299069 title "Sudden unexpected death in epilepsy" @default.
- W4225299069 cites W1495878550 @default.
- W4225299069 cites W1513838333 @default.
- W4225299069 cites W1526621317 @default.
- W4225299069 cites W1595266116 @default.
- W4225299069 cites W1642958044 @default.
- W4225299069 cites W1904913158 @default.
- W4225299069 cites W1973172826 @default.
- W4225299069 cites W2003630567 @default.
- W4225299069 cites W2008238826 @default.
- W4225299069 cites W2072470650 @default.
- W4225299069 cites W2100857624 @default.
- W4225299069 cites W2104068216 @default.
- W4225299069 cites W2119181594 @default.
- W4225299069 cites W2135415803 @default.
- W4225299069 cites W2135733572 @default.
- W4225299069 cites W2151371412 @default.
- W4225299069 cites W2152209925 @default.
- W4225299069 cites W2152261216 @default.
- W4225299069 cites W2159545545 @default.
- W4225299069 cites W2163553089 @default.
- W4225299069 cites W2164174930 @default.
- W4225299069 cites W2166419350 @default.
- W4225299069 cites W2212049882 @default.
- W4225299069 cites W2219551727 @default.
- W4225299069 cites W2237410055 @default.
- W4225299069 cites W2280939008 @default.
- W4225299069 cites W2299695249 @default.
- W4225299069 cites W2342873883 @default.
- W4225299069 cites W2402431342 @default.
- W4225299069 cites W2498582720 @default.
- W4225299069 cites W2579611109 @default.
- W4225299069 cites W2605252155 @default.
- W4225299069 cites W2605649423 @default.
- W4225299069 cites W2624258472 @default.
- W4225299069 cites W2646536716 @default.
- W4225299069 cites W2659665662 @default.
- W4225299069 cites W2733139594 @default.
- W4225299069 cites W2740631934 @default.
- W4225299069 cites W2756926107 @default.
- W4225299069 cites W2759409764 @default.
- W4225299069 cites W2782573859 @default.
- W4225299069 cites W2782833354 @default.
- W4225299069 cites W2783075047 @default.
- W4225299069 cites W2795098017 @default.
- W4225299069 cites W2796479708 @default.
- W4225299069 cites W2802131821 @default.
- W4225299069 cites W2804714363 @default.
- W4225299069 cites W2805680081 @default.
- W4225299069 cites W2805770579 @default.
- W4225299069 cites W2806819275 @default.
- W4225299069 cites W2886384416 @default.
- W4225299069 cites W2888577671 @default.
- W4225299069 cites W2904012242 @default.
- W4225299069 cites W2904372366 @default.
- W4225299069 cites W2905793278 @default.
- W4225299069 cites W2908965663 @default.
- W4225299069 cites W2910968574 @default.
- W4225299069 cites W2912681287 @default.
- W4225299069 cites W2920791392 @default.
- W4225299069 cites W2921261195 @default.
- W4225299069 cites W2937149071 @default.
- W4225299069 cites W2949432205 @default.
- W4225299069 cites W2962251621 @default.
- W4225299069 cites W2974825159 @default.
- W4225299069 cites W2979068930 @default.
- W4225299069 cites W2981683461 @default.
- W4225299069 cites W2982552014 @default.
- W4225299069 cites W2995886081 @default.
- W4225299069 cites W2996672198 @default.
- W4225299069 cites W3000704380 @default.
- W4225299069 cites W3005310124 @default.
- W4225299069 cites W3018854841 @default.
- W4225299069 cites W3035034281 @default.
- W4225299069 cites W3036099501 @default.
- W4225299069 cites W3042202258 @default.
- W4225299069 cites W3043084974 @default.
- W4225299069 cites W3088531119 @default.
- W4225299069 cites W3088993145 @default.
- W4225299069 cites W3098798596 @default.
- W4225299069 cites W3107349919 @default.
- W4225299069 cites W3108107453 @default.
- W4225299069 cites W3120710483 @default.
- W4225299069 cites W3129647207 @default.
- W4225299069 cites W3130395621 @default.
- W4225299069 cites W3132383697 @default.
- W4225299069 cites W3133692767 @default.
- W4225299069 cites W3158872799 @default.
- W4225299069 cites W3207143069 @default.
- W4225299069 cites W3210797596 @default.
- W4225299069 cites W4233084959 @default.
- W4225299069 cites W4301516559 @default.
- W4225299069 doi "https://doi.org/10.1097/wco.0000000000001034" @default.