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• W4225303465 abstract "The prognosis of advanced urological cancers (AUC) remains unfavorable, and few data are available regarding precision medicine.the PERMED-01 prospective clinical trial assessed the impact of molecular profiling in adults with refractory advanced solid cancer, in terms of number of patients with tumor actionable genetic alterations (AGA), feasibility, description of molecular alterations, treatment, and clinical outcome. We present here those results in the 64 patients enrolled with AUC. DNA extracted from a new tumor biopsy was profiled in real-time (targeted NGS, whole-genome array-comparative genomic hybridization), and the results were discussed during a weekly molecular tumor board meeting.a complete molecular profile was obtained in 49 patients (77%). Thirty-eight (59%) had at least one AGA. Twelve (19%) received a matched therapy on progression, of which 42% had a PFS2/PFS1 ratio ≥ 1.3 versus 5% in the non-matched therapy group (n = 25). The objective response and disease control rates were higher in the matched therapy group (33% and 58%, respectively) than in the non-matched therapy group (13% and 22%), as was the 6-month OS (75% vs. 42%).the profiling of a newly biopsied tumor sample identified AGA in 59% of patients with AUC, led to matched therapy in 19%, and provided clinical benefit in 8%." @default.
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• W4225303465 date "2022-05-03" @default.
• W4225303465 modified "2023-10-17" @default.
• W4225303465 title "Molecular Profiles of Advanced Urological Cancers in the PERMED-01 Precision Medicine Clinical Trial" @default.
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• W4225303465 doi "https://doi.org/10.3390/cancers14092275" @default.
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