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- W4225303610 endingPage "204173142210916" @default.
- W4225303610 startingPage "204173142210916" @default.
- W4225303610 abstract "Cancer is one of the leading causes of death worldwide. The tumour extracellular matrix (ECM) has unique features in terms of composition and mechanical properties, resulting in a structurally and chemically different ECM to that of native, healthy tissues. This paper reviews to date the efforts into decellularization of tumours, which in the authors' view represents a new frontier in the ever evolving field of tumour tissue engineering. An overview of the ECM and its importance in cancer is given, ending with examples of research using decellularized tumours, which has already indicated potential therapeutic targets, unravelled malignancy mechanisms or response to chemotherapy agents. The review highlights that more research is needed in this area, which can answer important questions related to tumour formation and progression to ultimately identify new and effective therapeutic targets. Within the near-future of personalized medicine, this research can create patient-specific tumour models and therapeutic regimes." @default.
- W4225303610 created "2022-05-05" @default.
- W4225303610 creator A5029758603 @default.
- W4225303610 creator A5034275921 @default.
- W4225303610 creator A5057527024 @default.
- W4225303610 date "2022-01-01" @default.
- W4225303610 modified "2023-09-30" @default.
- W4225303610 title "Decellularization of tumours: A new frontier in tissue engineering" @default.
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