Matches in SemOpenAlex for { <https://semopenalex.org/work/W4225313492> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W4225313492 endingPage "487" @default.
- W4225313492 startingPage "487" @default.
- W4225313492 abstract "<ns4:p><ns4:bold>Background:</ns4:bold> Buprenorphine, a partial agonist of the mu-opioid receptor, is an increasingly prescribed medication for maintenance treatment of opioid use disorder. When this medication is taken in the context of active opioid use, precipitated withdrawal can occur, leading to acute onset of opioid withdrawal symptoms. Fentanyl complicates use of buprenorphine, as it slowly releases from body stores and can lead to higher risk of precipitated withdrawal.</ns4:p><ns4:p> <ns4:bold>Objectives:</ns4:bold> Describe the successful management of buprenorphine precipitated opioid withdrawal from fentanyl with high doses of buprenorphine. We seek to highlight how no adverse effects occurred in this patient and illustrate his stable transition to outpatient treatment.</ns4:p><ns4:p> <ns4:bold>Case report:</ns4:bold> We present the case of a patient with severe opioid use disorder who presented in moderately severe opioid withdrawal after taking non-prescribed buprenorphine-naloxone which precipitated opioid withdrawal from daily fentanyl use. He was treated with high doses of buprenorphine, 148 mg over the first 48 hours, averaging 63 mg per day over four days. The patient reported rapid improvement in withdrawal symptoms without noted side effects and was able to successfully taper to 16 mg twice daily by discharge.</ns4:p><ns4:p> <ns4:bold>Conclusions:</ns4:bold> This case demonstrates the safety and effectiveness of buprenorphine at high doses for treatment of precipitated withdrawal. While other options include symptomatic withdrawal management, initiating methadone or less researched options like ketamine, utilizing buprenorphine can preserve or re-establish confidence in this life-saving medication. This case also increases the previously documented upper boundary on buprenorphine dosing for withdrawal and should provide additional confidence in its use.</ns4:p>" @default.
- W4225313492 created "2022-05-05" @default.
- W4225313492 creator A5015855040 @default.
- W4225313492 creator A5039136979 @default.
- W4225313492 creator A5067495762 @default.
- W4225313492 creator A5080010588 @default.
- W4225313492 date "2022-05-03" @default.
- W4225313492 modified "2023-10-18" @default.
- W4225313492 title "Case Report: Buprenorphine-precipitated fentanyl withdrawal treated with high-dose buprenorphine" @default.
- W4225313492 cites W1567908657 @default.
- W4225313492 cites W1580035123 @default.
- W4225313492 cites W1997040233 @default.
- W4225313492 cites W2018914766 @default.
- W4225313492 cites W2034572193 @default.
- W4225313492 cites W2040327352 @default.
- W4225313492 cites W2077956645 @default.
- W4225313492 cites W2100833669 @default.
- W4225313492 cites W2150438029 @default.
- W4225313492 cites W2729232923 @default.
- W4225313492 cites W2762128566 @default.
- W4225313492 cites W2903865762 @default.
- W4225313492 cites W2949184225 @default.
- W4225313492 cites W2990871804 @default.
- W4225313492 cites W3122497334 @default.
- W4225313492 cites W3178746109 @default.
- W4225313492 cites W3213991078 @default.
- W4225313492 cites W4225773474 @default.
- W4225313492 cites W4229023938 @default.
- W4225313492 cites W4252052363 @default.
- W4225313492 doi "https://doi.org/10.12688/f1000research.120821.1" @default.
- W4225313492 hasPublicationYear "2022" @default.
- W4225313492 type Work @default.
- W4225313492 citedByCount "1" @default.
- W4225313492 countsByYear W42253134922023 @default.
- W4225313492 crossrefType "journal-article" @default.
- W4225313492 hasAuthorship W4225313492A5015855040 @default.
- W4225313492 hasAuthorship W4225313492A5039136979 @default.
- W4225313492 hasAuthorship W4225313492A5067495762 @default.
- W4225313492 hasAuthorship W4225313492A5080010588 @default.
- W4225313492 hasBestOaLocation W42253134921 @default.
- W4225313492 hasConcept C126322002 @default.
- W4225313492 hasConcept C170493617 @default.
- W4225313492 hasConcept C2778949969 @default.
- W4225313492 hasConcept C2779418921 @default.
- W4225313492 hasConcept C2781063702 @default.
- W4225313492 hasConcept C2781072394 @default.
- W4225313492 hasConcept C42219234 @default.
- W4225313492 hasConcept C71924100 @default.
- W4225313492 hasConceptScore W4225313492C126322002 @default.
- W4225313492 hasConceptScore W4225313492C170493617 @default.
- W4225313492 hasConceptScore W4225313492C2778949969 @default.
- W4225313492 hasConceptScore W4225313492C2779418921 @default.
- W4225313492 hasConceptScore W4225313492C2781063702 @default.
- W4225313492 hasConceptScore W4225313492C2781072394 @default.
- W4225313492 hasConceptScore W4225313492C42219234 @default.
- W4225313492 hasConceptScore W4225313492C71924100 @default.
- W4225313492 hasFunder F4320310886 @default.
- W4225313492 hasFunder F4320332164 @default.
- W4225313492 hasFunder F4320332175 @default.
- W4225313492 hasLocation W42253134921 @default.
- W4225313492 hasOpenAccess W4225313492 @default.
- W4225313492 hasPrimaryLocation W42253134921 @default.
- W4225313492 hasRelatedWork W1982468213 @default.
- W4225313492 hasRelatedWork W207515104 @default.
- W4225313492 hasRelatedWork W2421536329 @default.
- W4225313492 hasRelatedWork W2907334930 @default.
- W4225313492 hasRelatedWork W2945926925 @default.
- W4225313492 hasRelatedWork W3183017455 @default.
- W4225313492 hasRelatedWork W4225422641 @default.
- W4225313492 hasRelatedWork W4226221537 @default.
- W4225313492 hasRelatedWork W4310952463 @default.
- W4225313492 hasRelatedWork W4360853218 @default.
- W4225313492 hasVolume "11" @default.
- W4225313492 isParatext "false" @default.
- W4225313492 isRetracted "false" @default.
- W4225313492 workType "article" @default.