FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4225319208> ?p ?o ?g. }

• W4225319208 endingPage "164" @default.
• W4225319208 startingPage "157" @default.
• W4225319208 abstract "Introduction: Neaodjuvant chemotherapy is used to treat high risk triple-negative breast cancer (TNBC). Residual cancer burden (RCB) is used to predict risk of relapse after neoadjuvant chemotherapy (NAC); however, it cannot predict disease recurrence with certainty. EZH2 is a targetable oncogenic protein overexpressed in TNBC and associated with metastasis and stem cell expansion. We quantified EZH2 protein expression in TNBC before NAC to examine potential utility as a predictive and prognostic biomarker. Materials and Methods: We retrospectively identified 63 patients with localized TNBC treated with NAC. We quantified EZH2 nuclear expression in pretherapy biopsies using a score which included intensity and percent of positive cells at each intensity. EZH2 expression was evaluated as a continuous variable and dichotomized at a score of 210. Logistic regression analysis was used to determine association between EZH2 expression and RCB, tumor-infiltrating lymphocytes, clinicopathologic features and disease-free survival. Results: There was no significant association between EZH2 score and posttreatment RCB class evaluated as a continuous variable ( P =0.831) or dichotomized at 210 ( P =0.546). On multivariable logistic regression, adjusted for covariates including RCB, EZH2 >210 was associated with development of metastasis (odds ratio=14.35, 95% confidence interval: 2.69-76.66; P =0.002). Logistic regression was run with EZH2 scores as a continuous variable and increased EZH2 score was associated with metastasis (odds ratio=1.10, 95% confidence interval: 1.00-1.03; P =0.047). Conclusion: In our study of TNBC treated with NAC, high EZH2 expression in pretherapy core biopsies was significantly associated with metastatic recurrence independent of RCB. The potential value of EZH2 as a biomarker to improve stratification of outcome after NAC should be explored further." @default.
• W4225319208 created "2022-05-05" @default.
• W4225319208 creator A5026505820 @default.
• W4225319208 creator A5046259123 @default.
• W4225319208 creator A5049425361 @default.
• W4225319208 creator A5061937236 @default.
• W4225319208 creator A5086230340 @default.
• W4225319208 date "2021-12-14" @default.
• W4225319208 modified "2023-09-24" @default.
• W4225319208 title "EZH2 Protein Expression in Triple-negative Breast Cancer Treated With Neoadjuvant Chemotherapy: An Exploratory Study of Association With Tumor Response and Prognosis" @default.
• W4225319208 cites W1755847251 @default.
• W4225319208 cites W1965225327 @default.
• W4225319208 cites W1996898892 @default.
• W4225319208 cites W2004742583 @default.
• W4225319208 cites W2004846981 @default.
• W4225319208 cites W2011336811 @default.
• W4225319208 cites W2024561801 @default.
• W4225319208 cites W2058112987 @default.
• W4225319208 cites W2059058989 @default.
• W4225319208 cites W2075894019 @default.
• W4225319208 cites W2077650275 @default.
• W4225319208 cites W2096027508 @default.
• W4225319208 cites W2096145980 @default.
• W4225319208 cites W2097255042 @default.
• W4225319208 cites W2099005045 @default.
• W4225319208 cites W2099869529 @default.
• W4225319208 cites W2100365251 @default.
• W4225319208 cites W2111717465 @default.
• W4225319208 cites W2120431466 @default.
• W4225319208 cites W2147415463 @default.
• W4225319208 cites W2147902297 @default.
• W4225319208 cites W2156267628 @default.
• W4225319208 cites W2169914436 @default.
• W4225319208 cites W2170602872 @default.
• W4225319208 cites W2208824773 @default.
• W4225319208 cites W2345135751 @default.
• W4225319208 cites W2402636472 @default.
• W4225319208 cites W2410383855 @default.
• W4225319208 cites W2466628694 @default.
• W4225319208 cites W2585697071 @default.
• W4225319208 cites W2618058692 @default.
• W4225319208 cites W2728674371 @default.
• W4225319208 cites W2781748744 @default.
• W4225319208 cites W2801437236 @default.
• W4225319208 cites W2802392118 @default.
• W4225319208 cites W2806074020 @default.
• W4225319208 cites W2898653873 @default.
• W4225319208 cites W2899401361 @default.
• W4225319208 cites W2999744434 @default.
• W4225319208 cites W3001127731 @default.
• W4225319208 cites W3021305401 @default.
• W4225319208 cites W3088976686 @default.
• W4225319208 cites W3108600954 @default.
• W4225319208 cites W3119005666 @default.
• W4225319208 cites W3126629852 @default.
• W4225319208 cites W3129906677 @default.
• W4225319208 doi "https://doi.org/10.1097/pai.0000000000000998" @default.
• W4225319208 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35262520" @default.
• W4225319208 hasPublicationYear "2021" @default.
• W4225319208 type Work @default.
• W4225319208 citedByCount "2" @default.
• W4225319208 countsByYear W42253192082022 @default.
• W4225319208 countsByYear W42253192082023 @default.
• W4225319208 crossrefType "journal-article" @default.
• W4225319208 hasAuthorship W4225319208A5026505820 @default.
• W4225319208 hasAuthorship W4225319208A5046259123 @default.
• W4225319208 hasAuthorship W4225319208A5049425361 @default.
• W4225319208 hasAuthorship W4225319208A5061937236 @default.
• W4225319208 hasAuthorship W4225319208A5086230340 @default.
• W4225319208 hasConcept C104317684 @default.
• W4225319208 hasConcept C121608353 @default.
• W4225319208 hasConcept C126322002 @default.
• W4225319208 hasConcept C143998085 @default.
• W4225319208 hasConcept C150194340 @default.
• W4225319208 hasConcept C151956035 @default.
• W4225319208 hasConcept C156957248 @default.
• W4225319208 hasConcept C2780110267 @default.
• W4225319208 hasConcept C44249647 @default.
• W4225319208 hasConcept C50171091 @default.
• W4225319208 hasConcept C530470458 @default.
• W4225319208 hasConcept C55493867 @default.
• W4225319208 hasConcept C71924100 @default.
• W4225319208 hasConcept C86803240 @default.
• W4225319208 hasConceptScore W4225319208C104317684 @default.
• W4225319208 hasConceptScore W4225319208C121608353 @default.
• W4225319208 hasConceptScore W4225319208C126322002 @default.
• W4225319208 hasConceptScore W4225319208C143998085 @default.
• W4225319208 hasConceptScore W4225319208C150194340 @default.
• W4225319208 hasConceptScore W4225319208C151956035 @default.
• W4225319208 hasConceptScore W4225319208C156957248 @default.
• W4225319208 hasConceptScore W4225319208C2780110267 @default.
• W4225319208 hasConceptScore W4225319208C44249647 @default.
• W4225319208 hasConceptScore W4225319208C50171091 @default.
• W4225319208 hasConceptScore W4225319208C530470458 @default.
• W4225319208 hasConceptScore W4225319208C55493867 @default.
• W4225319208 hasConceptScore W4225319208C71924100 @default.
• W4225319208 hasConceptScore W4225319208C86803240 @default.
• W4225319208 hasIssue "3" @default.

• next