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- W4225321116 endingPage "100208" @default.
- W4225321116 startingPage "100208" @default.
- W4225321116 abstract "Optogenetic manipulation of hippocampal circuitry is an important tool for investigating learning in vivo. Numerous approaches to pulse design have been employed to elicit desirable circuit and behavioral outcomes. Here, we systematically test the outcome of different single-pulse waveforms in a rate-based model of hippocampal memory function at the level of mnemonic replay extension and de novo synaptic weight formation in CA3 and CA1. Lower-power waveforms with long forward or forward and backward ramps yield more natural sequence replay dynamics and induce synaptic plasticity that allows for more natural memory replay timing, in contrast to square or backward ramps. These differences between waveform shape and amplitude are preserved with the addition of noise in membrane potential, light scattering, and protein expression, improving the potential validity of predictions for in vivo work. These results inform future optogenetic experimental design choices in the field of learning and memory." @default.
- W4225321116 created "2022-05-05" @default.
- W4225321116 creator A5028119977 @default.
- W4225321116 creator A5078226854 @default.
- W4225321116 creator A5088108309 @default.
- W4225321116 date "2022-05-01" @default.
- W4225321116 modified "2023-10-14" @default.
- W4225321116 title "Impact of optogenetic pulse design on CA3 learning and replay: A neural model" @default.
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- W4225321116 cites W1955575446 @default.
- W4225321116 cites W1966907489 @default.
- W4225321116 cites W1967456522 @default.
- W4225321116 cites W1974367810 @default.
- W4225321116 cites W1975958074 @default.
- W4225321116 cites W1980006923 @default.
- W4225321116 cites W1981998044 @default.
- W4225321116 cites W1989712467 @default.
- W4225321116 cites W1989932452 @default.
- W4225321116 cites W1990627393 @default.
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- W4225321116 cites W2010600019 @default.
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- W4225321116 cites W2025164836 @default.
- W4225321116 cites W2026425363 @default.
- W4225321116 cites W2028454935 @default.
- W4225321116 cites W2036773579 @default.
- W4225321116 cites W2039322071 @default.
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- W4225321116 cites W2044777055 @default.
- W4225321116 cites W2048528277 @default.
- W4225321116 cites W2053696585 @default.
- W4225321116 cites W2054347272 @default.
- W4225321116 cites W2056175699 @default.
- W4225321116 cites W2058113871 @default.
- W4225321116 cites W2060671266 @default.
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- W4225321116 cites W2115107366 @default.
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- W4225321116 cites W2127780691 @default.
- W4225321116 cites W2131422647 @default.
- W4225321116 cites W2139833890 @default.
- W4225321116 cites W2152779992 @default.
- W4225321116 cites W2155505956 @default.
- W4225321116 cites W2158256695 @default.
- W4225321116 cites W2158550713 @default.
- W4225321116 cites W2163213169 @default.
- W4225321116 cites W2167095271 @default.
- W4225321116 cites W2174241273 @default.
- W4225321116 cites W2263254196 @default.
- W4225321116 cites W2310925872 @default.
- W4225321116 cites W2508029759 @default.
- W4225321116 cites W2528809029 @default.
- W4225321116 cites W2557019990 @default.
- W4225321116 cites W2558867581 @default.
- W4225321116 cites W2607419807 @default.
- W4225321116 cites W2751166226 @default.
- W4225321116 cites W2796331061 @default.
- W4225321116 cites W2799710399 @default.
- W4225321116 cites W2802334093 @default.
- W4225321116 cites W2883712683 @default.
- W4225321116 cites W2940712369 @default.
- W4225321116 cites W2945623725 @default.
- W4225321116 cites W2949722813 @default.
- W4225321116 cites W2952426443 @default.
- W4225321116 cites W2956728914 @default.
- W4225321116 cites W2972587590 @default.
- W4225321116 cites W2975518817 @default.
- W4225321116 cites W2982510093 @default.
- W4225321116 cites W3005948598 @default.
- W4225321116 cites W3082939365 @default.
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- W4225321116 cites W3095668735 @default.
- W4225321116 cites W3115328114 @default.
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- W4225321116 cites W3171743717 @default.
- W4225321116 cites W4210700388 @default.
- W4225321116 cites W66960383 @default.
- W4225321116 cites W82867098 @default.
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- W4225321116 doi "https://doi.org/10.1016/j.crmeth.2022.100208" @default.
- W4225321116 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35637904" @default.
- W4225321116 hasPublicationYear "2022" @default.
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