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- W4225328438 endingPage "114102" @default.
- W4225328438 startingPage "114102" @default.
- W4225328438 abstract "Spinal cord injury (SCI) is a devastating event that can permanently disrupt multiple modalities. Unfortunately, the combination of the inhibitory environment at a central nervous system (CNS) injury site and the diminished intrinsic capacity of adult axons for growth results in the failure for robust axonal regeneration, limiting the ability for repair. Delivering genetic material that can either positively or negatively modulate gene expression has the potential to counter the obstacles that hinder axon growth within the spinal cord after injury. A popular gene therapy method is to deliver the genetic material using viral vectors. There are considerations when deciding on a viral vector approach for a particular application, including the type of vector, as well as serotypes, and promoters. In this review, we will discuss some of the aspects to consider when utilizing a viral vector approach to as a therapy for SCI. Additionally, we will discuss some recent applications of gene therapy to target extrinsic and/or intrinsic barriers to promote axon regeneration after SCI in preclinical models. While still in early stages, this approach has potential to treat those living with SCI." @default.
- W4225328438 created "2022-05-05" @default.
- W4225328438 creator A5016659031 @default.
- W4225328438 creator A5079442652 @default.
- W4225328438 date "2022-08-01" @default.
- W4225328438 modified "2023-10-14" @default.
- W4225328438 title "The use of viral vectors to promote repair after spinal cord injury" @default.
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