FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4225329042> ?p ?o ?g. }

• W4225329042 abstract "In many solid cancers, tumor-associated macrophages (TAM) represent the predominant myeloid cell population. Antigen (Ag) cross-presentation leading to tumor Ag–directed cytotoxic CD8+ T cell responses is crucial for antitumor immunity. However, the role of recruited monocyte-derived macrophages, including TAM, as potential cross-presenting cells is not well understood. Here, we show that primary human as well as mouse CD206+ macrophages are effective in functional cross-presentation of soluble self-Ag and non–self-Ag, including tumor-associated Ag (TAA), as well as viral Ag. To confirm the presence of cross-presenting TAM in vivo, we performed phenotypic and functional analysis of TAM from B16-F10 and CT26 syngeneic tumor models and have identified CD11b+F4/80hiCD206+ TAM to effectively cross-present TAA. We show that CD11b+CD206+ TAM represent the dominant tumor-infiltrating myeloid cell population, expressing a unique cell surface repertoire, promoting Ag cross-presentation and Ag-specific CD8+ T cell activation comparable with cross-presenting CLEC9A+ DCs (cDC1). The presence of cross-presenting CD206+ TAM is associated with reduced tumor burden in mouse syngeneic tumor models and with improved overall survival in cutaneous melanoma patients. Therefore, the demonstration of effective Ag cross-presentation capabilities of CD206+ TAM, including their clinical relevance, expands our understanding of TAM phenotypic diversity and functional versatility." @default.
• W4225329042 created "2022-05-05" @default.
• W4225329042 creator A5007393829 @default.
• W4225329042 creator A5012237204 @default.
• W4225329042 creator A5035373313 @default.
• W4225329042 creator A5036633776 @default.
• W4225329042 creator A5038390932 @default.
• W4225329042 creator A5042198781 @default.
• W4225329042 creator A5044929807 @default.
• W4225329042 creator A5044968513 @default.
• W4225329042 creator A5045462361 @default.
• W4225329042 creator A5051503867 @default.
• W4225329042 creator A5056116872 @default.
• W4225329042 creator A5059955413 @default.
• W4225329042 creator A5072084289 @default.
• W4225329042 creator A5077512987 @default.
• W4225329042 creator A5080949843 @default.
• W4225329042 creator A5083127884 @default.
• W4225329042 creator A5087143585 @default.
• W4225329042 creator A5090417806 @default.
• W4225329042 date "2022-06-08" @default.
• W4225329042 modified "2023-10-14" @default.
• W4225329042 title "CD206+ tumor-associated macrophages cross-present tumor antigen and drive antitumor immunity" @default.
• W4225329042 cites W1485641535 @default.
• W4225329042 cites W1843829844 @default.
• W4225329042 cites W1920177081 @default.
• W4225329042 cites W1923917571 @default.
• W4225329042 cites W1929729526 @default.
• W4225329042 cites W1969119554 @default.
• W4225329042 cites W1985859986 @default.
• W4225329042 cites W1992482869 @default.
• W4225329042 cites W2023164440 @default.
• W4225329042 cites W2040602022 @default.
• W4225329042 cites W2051949323 @default.
• W4225329042 cites W2055348159 @default.
• W4225329042 cites W2061334751 @default.
• W4225329042 cites W2061496310 @default.
• W4225329042 cites W2084697718 @default.
• W4225329042 cites W2092277031 @default.
• W4225329042 cites W2119668085 @default.
• W4225329042 cites W2123469465 @default.
• W4225329042 cites W2123631710 @default.
• W4225329042 cites W2127144270 @default.
• W4225329042 cites W2129585732 @default.
• W4225329042 cites W2145690342 @default.
• W4225329042 cites W2155595248 @default.
• W4225329042 cites W2159560463 @default.
• W4225329042 cites W2509914352 @default.
• W4225329042 cites W2558002947 @default.
• W4225329042 cites W2605708780 @default.
• W4225329042 cites W2607129810 @default.
• W4225329042 cites W2611596972 @default.
• W4225329042 cites W2784734333 @default.
• W4225329042 cites W2789566036 @default.
• W4225329042 cites W2793688609 @default.
• W4225329042 cites W2811427324 @default.
• W4225329042 cites W2890854864 @default.
• W4225329042 cites W2898415660 @default.
• W4225329042 cites W2903284507 @default.
• W4225329042 cites W2947216697 @default.
• W4225329042 cites W2949237386 @default.
• W4225329042 cites W2971790873 @default.
• W4225329042 cites W2972373126 @default.
• W4225329042 cites W2980823965 @default.
• W4225329042 cites W2982638381 @default.
• W4225329042 cites W2992070886 @default.
• W4225329042 cites W2994532040 @default.
• W4225329042 cites W3002902597 @default.
• W4225329042 cites W3005718174 @default.
• W4225329042 cites W3016360824 @default.
• W4225329042 cites W3022224433 @default.
• W4225329042 cites W3106806530 @default.
• W4225329042 cites W3113003370 @default.
• W4225329042 cites W3126902084 @default.
• W4225329042 cites W3138104526 @default.
• W4225329042 cites W3165484362 @default.
• W4225329042 cites W3197123215 @default.
• W4225329042 doi "https://doi.org/10.1172/jci.insight.155022" @default.
• W4225329042 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35503656" @default.
• W4225329042 hasPublicationYear "2022" @default.
• W4225329042 type Work @default.
• W4225329042 citedByCount "21" @default.
• W4225329042 countsByYear W42253290422022 @default.
• W4225329042 countsByYear W42253290422023 @default.
• W4225329042 crossrefType "journal-article" @default.
• W4225329042 hasAuthorship W4225329042A5007393829 @default.
• W4225329042 hasAuthorship W4225329042A5012237204 @default.
• W4225329042 hasAuthorship W4225329042A5035373313 @default.
• W4225329042 hasAuthorship W4225329042A5036633776 @default.
• W4225329042 hasAuthorship W4225329042A5038390932 @default.
• W4225329042 hasAuthorship W4225329042A5042198781 @default.
• W4225329042 hasAuthorship W4225329042A5044929807 @default.
• W4225329042 hasAuthorship W4225329042A5044968513 @default.
• W4225329042 hasAuthorship W4225329042A5045462361 @default.
• W4225329042 hasAuthorship W4225329042A5051503867 @default.
• W4225329042 hasAuthorship W4225329042A5056116872 @default.
• W4225329042 hasAuthorship W4225329042A5059955413 @default.
• W4225329042 hasAuthorship W4225329042A5072084289 @default.
• W4225329042 hasAuthorship W4225329042A5077512987 @default.
• W4225329042 hasAuthorship W4225329042A5080949843 @default.

• next