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- W4225348766 abstract "Oral lichen planus (OLP) is a T cell-mediated inflammatory disease of the oral mucosa that has been extensively researched over many years but as yet the mechanisms of pathogenesis are still not fully understood. Whilst the specific aetiological factors driving OLP remain ambiguous, evidence points to the development of a chronic, dysregulated immune response to OLP-mediating antigens presented by innate immune cells and oral keratinocytes leading to increased cytokine, chemokine and adhesion molecule expression. These molecules recruit T cells and mast cells to the diseased site and orchestrate a complex interplay between cells that culminates in keratinocyte cell death, mucosal basement membrane destruction and long-term chronicity of the disease. The main lymphocytes involved are thought to be CD8+ cytotoxic and CD4+ Th1 polarised T cells although recent evidence indicates the involvement of other Th subsets such as Th9, Th17 and Tregs, suggesting that a more complex immune cell relationship exists during the disease process. This review provides an overview of the immune mechanisms at play in OLP pathogenesis with particular emphasis on the role of the different Th subsets and how these recent discoveries may guide research towards identifying potential therapeutic targets." @default.
- W4225348766 created "2022-05-05" @default.
- W4225348766 creator A5025894707 @default.
- W4225348766 creator A5040015938 @default.
- W4225348766 creator A5066689668 @default.
- W4225348766 creator A5090644565 @default.
- W4225348766 date "2022-02-08" @default.
- W4225348766 modified "2023-10-10" @default.
- W4225348766 title "Immune mechanisms in oral lichen planus" @default.
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