Matches in SemOpenAlex for { <https://semopenalex.org/work/W4225352723> ?p ?o ?g. }
- W4225352723 abstract "Photodynamic therapy (PDT) is a promising therapeutic modality that can convert oxygen into cytotoxic reactive oxygen species (ROS) via photosensitizers to halt tumor growth. However, hypoxia and the unsatisfactory accumulation of photosensitizers in tumors severely diminish the therapeutic effect of PDT. In this study, a multistage nanoplatform is demonstrated to overcome these limitations by encapsulating photosensitizer IR780 and oxygen regulator 3-bromopyruvate (3BP) in poly (lactic-co-glycolic acid) (PLGA) nanocarriers.The as-synthesized nanoplatforms penetrated deeply into the interior region of tumors and preferentially remained in mitochondria due to the intrinsic characteristics of IR780. Meanwhile, 3BP could efficiently suppress oxygen consumption of tumor cells by inhibiting mitochondrial respiratory chain to further improve the generation of ROS. Furthermore, 3BP could abolish the excessive glycolytic capacity of tumor cells and lead to the collapse of ATP production, rendering tumor cells more susceptible to PDT. Successful tumor inhibition in animal models confirmed the therapeutic precision and efficiency. In addition, these nanoplatforms could act as fluorescence (FL) and photoacoustic (PA) imaging contrast agents, effectuating imaging-guided cancer treatment.This study provides an ideal strategy for cancer therapy by concurrent oxygen consumption reduction, oxygen-augmented PDT, energy supply reduction, mitochondria-targeted/deep-penetrated nanoplatforms and PA/FL dual-modal imaging guidance/monitoring. It is expected that such strategy will provide a promising alternative to maximize the performance of PDT in preclinical/clinical cancer treatment." @default.
- W4225352723 created "2022-05-05" @default.
- W4225352723 creator A5040030273 @default.
- W4225352723 creator A5041985123 @default.
- W4225352723 creator A5044936528 @default.
- W4225352723 creator A5046454314 @default.
- W4225352723 creator A5051943046 @default.
- W4225352723 creator A5060185042 @default.
- W4225352723 creator A5063779532 @default.
- W4225352723 creator A5066599847 @default.
- W4225352723 creator A5074322926 @default.
- W4225352723 creator A5074934997 @default.
- W4225352723 creator A5082595267 @default.
- W4225352723 creator A5086290413 @default.
- W4225352723 date "2021-12-20" @default.
- W4225352723 modified "2023-10-14" @default.
- W4225352723 title "Mitochondria-targeted nanoplatforms for enhanced photodynamic therapy against hypoxia tumor" @default.
- W4225352723 cites W1157613785 @default.
- W4225352723 cites W1889772831 @default.
- W4225352723 cites W1912124796 @default.
- W4225352723 cites W1988368086 @default.
- W4225352723 cites W2003417338 @default.
- W4225352723 cites W2039015357 @default.
- W4225352723 cites W2040917386 @default.
- W4225352723 cites W2063242571 @default.
- W4225352723 cites W2067005837 @default.
- W4225352723 cites W2070007419 @default.
- W4225352723 cites W2079142824 @default.
- W4225352723 cites W2086861031 @default.
- W4225352723 cites W2087240799 @default.
- W4225352723 cites W2088671304 @default.
- W4225352723 cites W2137960344 @default.
- W4225352723 cites W2140014506 @default.
- W4225352723 cites W2144277227 @default.
- W4225352723 cites W2156943914 @default.
- W4225352723 cites W2166571334 @default.
- W4225352723 cites W2212719824 @default.
- W4225352723 cites W2325287929 @default.
- W4225352723 cites W2488000435 @default.
- W4225352723 cites W2507894699 @default.
- W4225352723 cites W2519860162 @default.
- W4225352723 cites W2529562623 @default.
- W4225352723 cites W2569852605 @default.
- W4225352723 cites W2578281794 @default.
- W4225352723 cites W2597097635 @default.
- W4225352723 cites W2605407725 @default.
- W4225352723 cites W2728985030 @default.
- W4225352723 cites W2798209146 @default.
- W4225352723 cites W2803235708 @default.
- W4225352723 cites W2804784607 @default.
- W4225352723 cites W2884108060 @default.
- W4225352723 cites W2884126108 @default.
- W4225352723 cites W2886387724 @default.
- W4225352723 cites W2887202105 @default.
- W4225352723 cites W2900493058 @default.
- W4225352723 cites W2908281107 @default.
- W4225352723 cites W2912099053 @default.
- W4225352723 cites W2913185045 @default.
- W4225352723 cites W2914976666 @default.
- W4225352723 cites W2924116260 @default.
- W4225352723 cites W2945924062 @default.
- W4225352723 cites W2950454717 @default.
- W4225352723 cites W2975044015 @default.
- W4225352723 cites W2982182315 @default.
- W4225352723 cites W2982391580 @default.
- W4225352723 cites W2987284967 @default.
- W4225352723 cites W2999304663 @default.
- W4225352723 cites W3007452635 @default.
- W4225352723 cites W3013226550 @default.
- W4225352723 cites W3020279455 @default.
- W4225352723 cites W3039477626 @default.
- W4225352723 cites W3040212818 @default.
- W4225352723 cites W3043355147 @default.
- W4225352723 cites W3044858173 @default.
- W4225352723 cites W3045293399 @default.
- W4225352723 cites W3045576138 @default.
- W4225352723 cites W3048584869 @default.
- W4225352723 cites W3128939072 @default.
- W4225352723 cites W3150537830 @default.
- W4225352723 cites W3156346165 @default.
- W4225352723 cites W3157341223 @default.
- W4225352723 cites W3162401783 @default.
- W4225352723 cites W3178368488 @default.
- W4225352723 doi "https://doi.org/10.1186/s12951-021-01196-6" @default.
- W4225352723 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34930284" @default.
- W4225352723 hasPublicationYear "2021" @default.
- W4225352723 type Work @default.
- W4225352723 citedByCount "15" @default.
- W4225352723 countsByYear W42253527232022 @default.
- W4225352723 countsByYear W42253527232023 @default.
- W4225352723 crossrefType "journal-article" @default.
- W4225352723 hasAuthorship W4225352723A5040030273 @default.
- W4225352723 hasAuthorship W4225352723A5041985123 @default.
- W4225352723 hasAuthorship W4225352723A5044936528 @default.
- W4225352723 hasAuthorship W4225352723A5046454314 @default.
- W4225352723 hasAuthorship W4225352723A5051943046 @default.
- W4225352723 hasAuthorship W4225352723A5060185042 @default.
- W4225352723 hasAuthorship W4225352723A5063779532 @default.
- W4225352723 hasAuthorship W4225352723A5066599847 @default.
- W4225352723 hasAuthorship W4225352723A5074322926 @default.