FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4225356265> ?p ?o ?g. }

• W4225356265 endingPage "61" @default.
• W4225356265 startingPage "53" @default.
• W4225356265 abstract "Although the effects of cadmium (Cd) on the development of diabetes have been extensively investigated, the relationship between Cd exposure and the severity of established diabetes is unclear. Herein, we investigate the effects of long-term exposure to Cd in a streptozotocin-induced mouse model of type-2 diabetes mellitus (T2DM) and the underlying mechanism.C57BL/6 Mice were divided into the following four groups: (1) control group; (2) Cd-exposed group; (3) diabetic group; (4) Cd-exposed diabetic group. Cd exposure was established by the administration of 155 ppm CdCl2 in drinking water. After 25 weeks of treatment, serum fasting glucose and insulin were measured. Meanwhile, the liver and pancreas specimens were sectioned and stained with Hematoxylin and eosin. Gluconeogenesis, glycolysis, lactate concentration, and fibrosis in liver were evaluated.Clinical signs attributable to diabetes were more apparent in Cd-exposed diabetic mice, while no effects of Cd exposure were found on non-diabetic mice. Cd exposure significantly decreased fasting blood glucose (FBG) levels in diabetic group. We further demonstrated that the glycolysis related hepatic enzymes, pyruvate kinase M2 (PKM-2) and lactic dehydrogenase A (LDHA) were both increased, while the gluconeogenesis related hepatic enzymes, phosphoenolpyruvate-1 (PCK-1) and glucose-6-phosphatase (G6Pase) were both decreased in Cd exposed diabetic mice, indicating that Cd increased glycolysis and inhibited gluconeogenesis in diabetic model. Moreover, lactate accumulation was noted accompanied by the increased inflammation and fibrosis in the livers of diabetic mice following Cd exposure.Cd exposure disturbed glucose metabolism and exacerbated diabetes, providing a biological relevance that DM patients are at greater risk when exposed to Cd." @default.
• W4225356265 created "2022-05-05" @default.
• W4225356265 creator A5006901857 @default.
• W4225356265 creator A5014522255 @default.
• W4225356265 creator A5029209186 @default.
• W4225356265 creator A5029946455 @default.
• W4225356265 creator A5039841643 @default.
• W4225356265 creator A5073501391 @default.
• W4225356265 creator A5084111820 @default.
• W4225356265 creator A5091194171 @default.
• W4225356265 date "2022-01-18" @default.
• W4225356265 modified "2023-10-18" @default.
• W4225356265 title "Cadmium exposure decreases fasting blood glucose levels and exacerbates type-2 diabetes in a mouse model" @default.
• W4225356265 cites W1567503997 @default.
• W4225356265 cites W1888759561 @default.
• W4225356265 cites W1990012689 @default.
• W4225356265 cites W2000518233 @default.
• W4225356265 cites W2013005364 @default.
• W4225356265 cites W2035755240 @default.
• W4225356265 cites W2043722033 @default.
• W4225356265 cites W2059240811 @default.
• W4225356265 cites W2155584216 @default.
• W4225356265 cites W2170448114 @default.
• W4225356265 cites W2228338508 @default.
• W4225356265 cites W2321413400 @default.
• W4225356265 cites W2409763770 @default.
• W4225356265 cites W2512409286 @default.
• W4225356265 cites W2608649154 @default.
• W4225356265 cites W2620558147 @default.
• W4225356265 cites W2736029153 @default.
• W4225356265 cites W2773541139 @default.
• W4225356265 cites W2789552870 @default.
• W4225356265 cites W2802240047 @default.
• W4225356265 cites W2803899017 @default.
• W4225356265 cites W2806957854 @default.
• W4225356265 cites W2903378764 @default.
• W4225356265 cites W2944013825 @default.
• W4225356265 cites W2944221497 @default.
• W4225356265 cites W2949375004 @default.
• W4225356265 cites W2964329052 @default.
• W4225356265 cites W2978097553 @default.
• W4225356265 cites W3008741896 @default.
• W4225356265 cites W3011403822 @default.
• W4225356265 cites W3012034345 @default.
• W4225356265 cites W3013687896 @default.
• W4225356265 cites W3026693639 @default.
• W4225356265 cites W3032103849 @default.
• W4225356265 cites W3092391366 @default.
• W4225356265 cites W3110030170 @default.
• W4225356265 cites W3116717064 @default.
• W4225356265 cites W3117728820 @default.
• W4225356265 cites W3121014404 @default.
• W4225356265 cites W3181022135 @default.
• W4225356265 cites W3186880212 @default.
• W4225356265 cites W3207298596 @default.
• W4225356265 cites W3207849593 @default.
• W4225356265 cites W2049617264 @default.
• W4225356265 doi "https://doi.org/10.1007/s12020-021-02974-w" @default.
• W4225356265 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35041127" @default.
• W4225356265 hasPublicationYear "2022" @default.
• W4225356265 type Work @default.
• W4225356265 citedByCount "6" @default.
• W4225356265 countsByYear W42253562652022 @default.
• W4225356265 countsByYear W42253562652023 @default.
• W4225356265 crossrefType "journal-article" @default.
• W4225356265 hasAuthorship W4225356265A5006901857 @default.
• W4225356265 hasAuthorship W4225356265A5014522255 @default.
• W4225356265 hasAuthorship W4225356265A5029209186 @default.
• W4225356265 hasAuthorship W4225356265A5029946455 @default.
• W4225356265 hasAuthorship W4225356265A5039841643 @default.
• W4225356265 hasAuthorship W4225356265A5073501391 @default.
• W4225356265 hasAuthorship W4225356265A5084111820 @default.
• W4225356265 hasAuthorship W4225356265A5091194171 @default.
• W4225356265 hasBestOaLocation W42253562652 @default.
• W4225356265 hasConcept C126322002 @default.
• W4225356265 hasConcept C134018914 @default.
• W4225356265 hasConcept C143937172 @default.
• W4225356265 hasConcept C17093226 @default.
• W4225356265 hasConcept C181199279 @default.
• W4225356265 hasConcept C20251656 @default.
• W4225356265 hasConcept C20904676 @default.
• W4225356265 hasConcept C2777318727 @default.
• W4225356265 hasConcept C2779280383 @default.
• W4225356265 hasConcept C2780854706 @default.
• W4225356265 hasConcept C2781232474 @default.
• W4225356265 hasConcept C55493867 @default.
• W4225356265 hasConcept C555293320 @default.
• W4225356265 hasConcept C62231903 @default.
• W4225356265 hasConcept C71924100 @default.
• W4225356265 hasConcept C86803240 @default.
• W4225356265 hasConceptScore W4225356265C126322002 @default.
• W4225356265 hasConceptScore W4225356265C134018914 @default.
• W4225356265 hasConceptScore W4225356265C143937172 @default.
• W4225356265 hasConceptScore W4225356265C17093226 @default.
• W4225356265 hasConceptScore W4225356265C181199279 @default.
• W4225356265 hasConceptScore W4225356265C20251656 @default.
• W4225356265 hasConceptScore W4225356265C20904676 @default.
• W4225356265 hasConceptScore W4225356265C2777318727 @default.

• next