Matches in SemOpenAlex for { <https://semopenalex.org/work/W4225361489> ?p ?o ?g. }
- W4225361489 endingPage "71" @default.
- W4225361489 startingPage "60" @default.
- W4225361489 abstract "Complement activation in kidney transplantation is implicated in the pathogenesis of delayed graft function (DGF). This study evaluated the therapeutic efficacy of high-dose recombinant human C1 esterase inhibitor (rhC1INH) to prevent DGF in a nonhuman primate model of kidney transplantation after brain death and prolonged cold ischemia.Brain death donors underwent 20 h of conventional management. Procured kidneys were stored on ice for 44-48 h, then transplanted into ABO-compatible major histocompatibility complex-mismatched recipients. Recipients were treated with vehicle (n = 5) or rhC1INH 500 U/kg plus heparin 40 U/kg (n = 8) before reperfusion, 12 h, and 24 h posttransplant. Recipients were followed up for 120 d.Of vehicle-treated recipients, 80% (4 of 5) developed DGF versus 12.5% (1 of 8) rhC1INH-treated recipients (P = 0.015). rhC1INH-treated recipients had faster creatinine recovery, superior urinary output, and reduced urinary neutrophil gelatinase-associated lipocalin and tissue inhibitor of metalloproteinases 2-insulin-like growth factor-binding protein 7 throughout the first week, indicating reduced allograft injury. Treated recipients presented lower postreperfusion plasma interleukin (IL)-6, IL-8, tumor necrosis factor-alpha, and IL-18, lower day 4 monocyte chemoattractant protein 1, and trended toward lower C5. Treated recipients exhibited less C3b/C5b-9 deposition on day 7 biopsies. rhC1INH-treated animals also trended toward prolonged mediated rejection-free survival.Our results recommend high-dose C1INH complement blockade in transplant recipients as an effective strategy to reduce kidney injury and inflammation, prevent DGF, delay antibody-mediated rejection development, and improve transplant outcomes." @default.
- W4225361489 created "2022-05-05" @default.
- W4225361489 creator A5001005514 @default.
- W4225361489 creator A5002689245 @default.
- W4225361489 creator A5005092225 @default.
- W4225361489 creator A5006196890 @default.
- W4225361489 creator A5008871183 @default.
- W4225361489 creator A5010621404 @default.
- W4225361489 creator A5015662852 @default.
- W4225361489 creator A5018453193 @default.
- W4225361489 creator A5023209801 @default.
- W4225361489 creator A5025362025 @default.
- W4225361489 creator A5033419488 @default.
- W4225361489 creator A5037698048 @default.
- W4225361489 creator A5048963494 @default.
- W4225361489 creator A5056975539 @default.
- W4225361489 creator A5059001620 @default.
- W4225361489 creator A5063531322 @default.
- W4225361489 creator A5065459929 @default.
- W4225361489 creator A5071458920 @default.
- W4225361489 creator A5082344358 @default.
- W4225361489 creator A5089415627 @default.
- W4225361489 creator A5091502681 @default.
- W4225361489 date "2021-12-13" @default.
- W4225361489 modified "2023-10-16" @default.
- W4225361489 title "Complement Blockade in Recipients Prevents Delayed Graft Function and Delays Antibody-mediated Rejection in a Nonhuman Primate Model of Kidney Transplantation" @default.
- W4225361489 cites W1488753362 @default.
- W4225361489 cites W1516284454 @default.
- W4225361489 cites W1527011538 @default.
- W4225361489 cites W1559646277 @default.
- W4225361489 cites W1575309759 @default.
- W4225361489 cites W1615315558 @default.
- W4225361489 cites W1675650869 @default.
- W4225361489 cites W1744376040 @default.
- W4225361489 cites W1895726885 @default.
- W4225361489 cites W1965211796 @default.
- W4225361489 cites W1967819647 @default.
- W4225361489 cites W1973896538 @default.
- W4225361489 cites W1974117309 @default.
- W4225361489 cites W1980351498 @default.
- W4225361489 cites W1996868603 @default.
- W4225361489 cites W1998450726 @default.
- W4225361489 cites W2001682169 @default.
- W4225361489 cites W2002240598 @default.
- W4225361489 cites W2010525793 @default.
- W4225361489 cites W2012231609 @default.
- W4225361489 cites W2015696064 @default.
- W4225361489 cites W2015703410 @default.
- W4225361489 cites W2024889997 @default.
- W4225361489 cites W2026660662 @default.
- W4225361489 cites W2030002999 @default.
- W4225361489 cites W2031896407 @default.
- W4225361489 cites W2035170959 @default.
- W4225361489 cites W2037584068 @default.
- W4225361489 cites W2037695327 @default.
- W4225361489 cites W2037916490 @default.
- W4225361489 cites W2038036434 @default.
- W4225361489 cites W2045322776 @default.
- W4225361489 cites W2046247020 @default.
- W4225361489 cites W2047124888 @default.
- W4225361489 cites W2056817358 @default.
- W4225361489 cites W2059502318 @default.
- W4225361489 cites W2060206045 @default.
- W4225361489 cites W2060508116 @default.
- W4225361489 cites W2061689465 @default.
- W4225361489 cites W2066516889 @default.
- W4225361489 cites W2076542934 @default.
- W4225361489 cites W2082340087 @default.
- W4225361489 cites W2096895041 @default.
- W4225361489 cites W2105624815 @default.
- W4225361489 cites W2108298583 @default.
- W4225361489 cites W2111220627 @default.
- W4225361489 cites W2115660072 @default.
- W4225361489 cites W2118674671 @default.
- W4225361489 cites W2123156974 @default.
- W4225361489 cites W2134937673 @default.
- W4225361489 cites W2149152348 @default.
- W4225361489 cites W2155807513 @default.
- W4225361489 cites W2157147056 @default.
- W4225361489 cites W2170433159 @default.
- W4225361489 cites W2202659380 @default.
- W4225361489 cites W2255620603 @default.
- W4225361489 cites W2289115148 @default.
- W4225361489 cites W2297009623 @default.
- W4225361489 cites W2318960790 @default.
- W4225361489 cites W2330025728 @default.
- W4225361489 cites W2521429693 @default.
- W4225361489 cites W2526207516 @default.
- W4225361489 cites W2530547316 @default.
- W4225361489 cites W2564107867 @default.
- W4225361489 cites W2608379914 @default.
- W4225361489 cites W2679240704 @default.
- W4225361489 cites W2737059355 @default.
- W4225361489 cites W2755301912 @default.
- W4225361489 cites W2773760837 @default.
- W4225361489 cites W2774126255 @default.
- W4225361489 cites W2778274386 @default.
- W4225361489 cites W2782396290 @default.