Matches in SemOpenAlex for { <https://semopenalex.org/work/W4225374865> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W4225374865 endingPage "17" @default.
- W4225374865 startingPage "10" @default.
- W4225374865 abstract "The aim. The purpose of this review is to summarize data on the synthesis and structural modification of heterocyclic systems with triazole and thiadiazole fragments in molecules as promising objects in bioorganic and medicinal chemistry.
 Materials and methods. The research based on bibliosemantic and analytical methods using bibliographic and abstract databases, as well as databases of chemical compounds.
 Results. Modern medicinal chemistry faces many challenges, one of which is the determination of the activity and specificity of therapeutic agents. Recent scientific data showed that triazoles and/or thiadiazoles have broad spectrum of biological activities, in particular antimicrobial, antifungal, antiviral, anticancer and anticonvulsant. Synthetic research allows to propose a whole number of new molecular design directions of biological active triazole and/or thiadiazole derivatives, as well as to obtain directed library that include hundreds of new compounds. This review is an effort to summarize data of its analgesic and anti-inflammatory activity over the last decade. We summarized and analyzed the series of triazole and/or thiadiazole derivatives and provided data of their structure-activity relationship. For optimization and rational design of highly active molecules with optimal «drug-like» characteristics and discovering of possible mechanism of action SAR, QSAR analysis and molecular docking were summarized.
 Conclusions. It has been shown that heterocyclic systems containing fragments of triazole and / or thiadiazole are a significant source of promising analgesic and/or anti-inflammatory agents. It has been established that the mentioned heterocyclic derivatives have a high selectivity of action, low toxicity and an effect commensurate with standard drugs" @default.
- W4225374865 created "2022-05-05" @default.
- W4225374865 creator A5018379660 @default.
- W4225374865 creator A5067788923 @default.
- W4225374865 creator A5070201675 @default.
- W4225374865 creator A5076992453 @default.
- W4225374865 date "2022-04-29" @default.
- W4225374865 modified "2023-09-26" @default.
- W4225374865 title "An overview on 1,2,4-triazole and 1,3,4-thiadiazole derivatives as potential anesthesic and anti-inflammatory agents" @default.
- W4225374865 doi "https://doi.org/10.15587/2519-4852.2022.255276" @default.
- W4225374865 hasPublicationYear "2022" @default.
- W4225374865 type Work @default.
- W4225374865 citedByCount "0" @default.
- W4225374865 crossrefType "journal-article" @default.
- W4225374865 hasAuthorship W4225374865A5018379660 @default.
- W4225374865 hasAuthorship W4225374865A5067788923 @default.
- W4225374865 hasAuthorship W4225374865A5070201675 @default.
- W4225374865 hasAuthorship W4225374865A5076992453 @default.
- W4225374865 hasBestOaLocation W42253748651 @default.
- W4225374865 hasConcept C164126121 @default.
- W4225374865 hasConcept C171250308 @default.
- W4225374865 hasConcept C178790620 @default.
- W4225374865 hasConcept C185592680 @default.
- W4225374865 hasConcept C192562407 @default.
- W4225374865 hasConcept C21951064 @default.
- W4225374865 hasConcept C2777907353 @default.
- W4225374865 hasConcept C2779548794 @default.
- W4225374865 hasConcept C2779668152 @default.
- W4225374865 hasConcept C4937899 @default.
- W4225374865 hasConcept C53105671 @default.
- W4225374865 hasConcept C70721500 @default.
- W4225374865 hasConcept C71240020 @default.
- W4225374865 hasConcept C86803240 @default.
- W4225374865 hasConcept C89423630 @default.
- W4225374865 hasConceptScore W4225374865C164126121 @default.
- W4225374865 hasConceptScore W4225374865C171250308 @default.
- W4225374865 hasConceptScore W4225374865C178790620 @default.
- W4225374865 hasConceptScore W4225374865C185592680 @default.
- W4225374865 hasConceptScore W4225374865C192562407 @default.
- W4225374865 hasConceptScore W4225374865C21951064 @default.
- W4225374865 hasConceptScore W4225374865C2777907353 @default.
- W4225374865 hasConceptScore W4225374865C2779548794 @default.
- W4225374865 hasConceptScore W4225374865C2779668152 @default.
- W4225374865 hasConceptScore W4225374865C4937899 @default.
- W4225374865 hasConceptScore W4225374865C53105671 @default.
- W4225374865 hasConceptScore W4225374865C70721500 @default.
- W4225374865 hasConceptScore W4225374865C71240020 @default.
- W4225374865 hasConceptScore W4225374865C86803240 @default.
- W4225374865 hasConceptScore W4225374865C89423630 @default.
- W4225374865 hasIssue "2(36)" @default.
- W4225374865 hasLocation W42253748651 @default.
- W4225374865 hasLocation W42253748652 @default.
- W4225374865 hasLocation W42253748653 @default.
- W4225374865 hasOpenAccess W4225374865 @default.
- W4225374865 hasPrimaryLocation W42253748651 @default.
- W4225374865 hasRelatedWork W1968606323 @default.
- W4225374865 hasRelatedWork W2005162532 @default.
- W4225374865 hasRelatedWork W2061703692 @default.
- W4225374865 hasRelatedWork W2097382139 @default.
- W4225374865 hasRelatedWork W2138539081 @default.
- W4225374865 hasRelatedWork W2177681712 @default.
- W4225374865 hasRelatedWork W2205255224 @default.
- W4225374865 hasRelatedWork W2248315687 @default.
- W4225374865 hasRelatedWork W2776290859 @default.
- W4225374865 hasRelatedWork W3140569656 @default.
- W4225374865 isParatext "false" @default.
- W4225374865 isRetracted "false" @default.
- W4225374865 workType "article" @default.