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- W4225375061 abstract "The effects of uricosuric agents have been evaluated in vitro with indices of uric acid uptake into human urate transporter 1 (URAT1)-overexpressed oocytes or cells. In the present study, we evaluated a method using primary human renal proximal tubule epithelial cells (RPTECs). Pretreatment of RPTECs with insulin significantly increased the uptake of uric acid into these cells. The uric acid uptake was inhibited in a concentration-dependent manner by the URAT1 inhibitors benzbromarone and dotinurad. Therefore, effects of uricosuric agents can be evaluated by the novel method, which is closer to the physiological system compared with previous methods." @default.
- W4225375061 created "2022-05-05" @default.
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- W4225375061 date "2022-05-03" @default.
- W4225375061 modified "2023-09-30" @default.
- W4225375061 title "An evaluation method for uric acid uptake inhibition using primary human proximal tubule epithelial cells treated with insulin" @default.
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- W4225375061 doi "https://doi.org/10.1080/15257770.2022.2070204" @default.
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