FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4225377430> ?p ?o ?g. }

• W4225377430 abstract "Neurons in the trigeminal ganglion relay sensory information from the face and oral cavity to the brain. The trigeminal ganglion is unique in its complexity, containing a mixed population of modality-specific (i.e., touch, pain) neurons derived from both neural crest and placodal precursors. The identity of trigeminal ganglion neurons is associated with the expression of Trk neurotrophin receptors, which are required for long-term neuronal function and survival. Within sensory ganglia, nociceptive neurons that detect pain or temperature generally express TrkA, while mechanoreceptors responding to touch express TrkB or TrkC. However, the processes that guide the emergence and maintenance of distinct neuronal subpopulations in the trigeminal ganglion are poorly understood. We recently uncovered a role for Elongator complex protein 1 (Elp1) in the maintenance of TrkA-expressing trigeminal ganglion nociceptors. Mutation of ELP1 causes Familial Dysautonomia (FD), a fatal neuropathy characterized, in part, by trigeminal sensory deficits, including impaired facial nociception. In a mouse model of FD, where Elp1 is deleted from neural crest derivatives (Elp1 CKO), we found that Elp1 is required for proper trigeminal nerve morphology. Moreover, loss of Elp1 reduces TrkA levels and enhances death of TrkA neurons during embryogenesis, explaining the facial sensory impairments experienced by FD patients. Given the targeted effects on TrkA neurons in Elp1 CKO, we hypothesized that most TrkA neurons in the trigeminal ganglion arise from the neural crest, while TrkB and TrkC neurons originate from placode cells. To address this, we first examined whether individual Trk receptors are co-expressed with the transcription factor Six1, which has previously been used to identify placodal neurons in the trigeminal ganglion. We discovered that Six1 is expressed in waves, marking newly differentiated trigeminal ganglion neurons regardless of presumptive placode or neural crest origin. Without bona fide immunohistochemical lineage markers, a Wnt1-Cre reporter mouse was used to identify neural crest (Wnt1-Cre recombined) versus placode (not recombined) derivatives. In support of our hypothesis, we observed a majority of TrkA neurons in the trigeminal ganglion had previously undergone Cre recombination, indicating trigeminal ganglion nociceptors are largely neural crest-derived. In contrast, most TrkB and TrkC neurons were not targeted for recombination, confirming trigeminal ganglion mechanoreceptors generally arise from placodes. Lastly, the majority of Six1-expressing cells were, indeed, Wnt1-Cre recombined once neural crest neuronal differentiation commenced in the trigeminal ganglion, confirming that Six1 is not exclusively expressed by placodal neurons at later stages. Future studies will expand upon this work by crossing the Wnt1-Cre reporter with Elp1 CKO to evaluate how Elp1 regulates the development and interactions of neural crest versus placodal derivatives within the trigeminal ganglion. Together, these findings provide novel insight into the origin and maintenance of trigeminal ganglion neurons and enhance our understanding of the pathogenesis of FD and other sensory nerve disorders." @default.
• W4225377430 created "2022-05-05" @default.
• W4225377430 creator A5045358263 @default.
• W4225377430 creator A5084822249 @default.
• W4225377430 date "2022-05-01" @default.
• W4225377430 modified "2023-09-28" @default.
• W4225377430 title "Neural Crest‐Specific Elp1 Deletion Disrupts Trigeminal Ganglion Development in a Model of Familial Dysautonomia" @default.
• W4225377430 doi "https://doi.org/10.1096/fasebj.2022.36.s1.r2520" @default.
• W4225377430 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35557309" @default.
• W4225377430 hasPublicationYear "2022" @default.
• W4225377430 type Work @default.
• W4225377430 citedByCount "0" @default.
• W4225377430 crossrefType "journal-article" @default.
• W4225377430 hasAuthorship W4225377430A5045358263 @default.
• W4225377430 hasAuthorship W4225377430A5084822249 @default.
• W4225377430 hasConcept C105702510 @default.
• W4225377430 hasConcept C126749454 @default.
• W4225377430 hasConcept C134139212 @default.
• W4225377430 hasConcept C15490471 @default.
• W4225377430 hasConcept C160539049 @default.
• W4225377430 hasConcept C169760540 @default.
• W4225377430 hasConcept C170493617 @default.
• W4225377430 hasConcept C171034665 @default.
• W4225377430 hasConcept C172659308 @default.
• W4225377430 hasConcept C180361614 @default.
• W4225377430 hasConcept C196843134 @default.
• W4225377430 hasConcept C2775960820 @default.
• W4225377430 hasConcept C2776352249 @default.
• W4225377430 hasConcept C54355233 @default.
• W4225377430 hasConcept C56703729 @default.
• W4225377430 hasConcept C79186569 @default.
• W4225377430 hasConcept C86803240 @default.
• W4225377430 hasConcept C92020748 @default.
• W4225377430 hasConcept C94487597 @default.
• W4225377430 hasConcept C95444343 @default.
• W4225377430 hasConcept C97124661 @default.
• W4225377430 hasConceptScore W4225377430C105702510 @default.
• W4225377430 hasConceptScore W4225377430C126749454 @default.
• W4225377430 hasConceptScore W4225377430C134139212 @default.
• W4225377430 hasConceptScore W4225377430C15490471 @default.
• W4225377430 hasConceptScore W4225377430C160539049 @default.
• W4225377430 hasConceptScore W4225377430C169760540 @default.
• W4225377430 hasConceptScore W4225377430C170493617 @default.
• W4225377430 hasConceptScore W4225377430C171034665 @default.
• W4225377430 hasConceptScore W4225377430C172659308 @default.
• W4225377430 hasConceptScore W4225377430C180361614 @default.
• W4225377430 hasConceptScore W4225377430C196843134 @default.
• W4225377430 hasConceptScore W4225377430C2775960820 @default.
• W4225377430 hasConceptScore W4225377430C2776352249 @default.
• W4225377430 hasConceptScore W4225377430C54355233 @default.
• W4225377430 hasConceptScore W4225377430C56703729 @default.
• W4225377430 hasConceptScore W4225377430C79186569 @default.
• W4225377430 hasConceptScore W4225377430C86803240 @default.
• W4225377430 hasConceptScore W4225377430C92020748 @default.
• W4225377430 hasConceptScore W4225377430C94487597 @default.
• W4225377430 hasConceptScore W4225377430C95444343 @default.
• W4225377430 hasConceptScore W4225377430C97124661 @default.
• W4225377430 hasFunder F4320332161 @default.
• W4225377430 hasIssue "S1" @default.
• W4225377430 hasLocation W42253774301 @default.
• W4225377430 hasLocation W42253774302 @default.
• W4225377430 hasOpenAccess W4225377430 @default.
• W4225377430 hasPrimaryLocation W42253774301 @default.
• W4225377430 hasRelatedWork W1971833191 @default.
• W4225377430 hasRelatedWork W1978564871 @default.
• W4225377430 hasRelatedWork W1986262535 @default.
• W4225377430 hasRelatedWork W2011799913 @default.
• W4225377430 hasRelatedWork W2076897469 @default.
• W4225377430 hasRelatedWork W2088570995 @default.
• W4225377430 hasRelatedWork W2138066183 @default.
• W4225377430 hasRelatedWork W2182013839 @default.
• W4225377430 hasRelatedWork W2789598930 @default.
• W4225377430 hasRelatedWork W4225377430 @default.
• W4225377430 hasVolume "36" @default.
• W4225377430 isParatext "false" @default.
• W4225377430 isRetracted "false" @default.
• W4225377430 workType "article" @default.