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- W4225378621 abstract "Objective: To investigate the prognostic value of DNA methylation of tumor suppressor genes for hepatocellular carcinoma (HCC) recurrence after liver transplantation. Methods:APC gene was selected according to The Cancer Genome Atlas dataset. Tumor tissues and clinical data of 85 HCC patients who received a liver transplantation were retrospectively enrolled and next-generation methylation sequencing was performed. Risk factors were determined using the Cox proportional-hazard-regression model. Results: The APC methylation site (chromosome 5, position 112043544) was an independent predictor of post-transplant HCC recurrence. Patients with hyper-methylated APC112043544 experienced superior recurrence-free survival (p = 0.021) and had a decreased proportion of microvascular invasion (p = 0.017). APC112043544 also predicted recurrence risk in patients beyond selection criteria. Conclusions:APC112043544 methylation may serve as a potential biomarker for post-transplant HCC recurrence." @default.
- W4225378621 created "2022-05-05" @default.
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- W4225378621 date "2022-05-03" @default.
- W4225378621 modified "2023-09-29" @default.
- W4225378621 title "Methylation site <i>APC</i>112043544 as a potential biomarker for post-transplant hepatocellular carcinoma recurrence" @default.
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- W4225378621 doi "https://doi.org/10.2217/fon-2021-1608" @default.
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