Matches in SemOpenAlex for { <https://semopenalex.org/work/W4225381327> ?p ?o ?g. }
- W4225381327 abstract "The luminal subtype accounts for ~70% of newly diagnosed breast cancer patients. Although it has a better prognosis, approximately 30% of them develop a late relapse. Identifying those patients is of interest to improve treatment decisions.A retrospective observational, single-centre study based on data from medical records of 572 non-metastatic (I-III) invasive ductal breast carcinoma patients, 448 with luminal tumours and 124 with triple-negative tumours. Kaplan-Meier, Cox regression and time-dependent Cox regression were carried out to obtain the prognosis value of risk factors.During a median observation of 5.5 years, 105 distant metastasis events and 105 all-cause deaths were observed. In addition to known clinicopathological factors (i.e., age, tumour size and lymph node metastasis), the high semi-quantitative expression of both hormone receptors was associated with distant metastasis-free survival (DMFS) (adjusted hazard ratio (HaR): 0.524 (0.316-0.867), p = 0.012) and overall survival (OS) (adjusted HaR: 0.486 (0.286-0.827), p = 0.008). The stratified analysis made it possible to identify risk modification factors. Subsequent stratification by histological grade, Ki-67 and semi-quantitative PR expression or, mainly, the composite semi-quantitative expression of hormone receptors (cHR) enabled the identification of luminal breast cancer patients of adjuvant schema at higher risk for metastasis and death. However, initial analyses including patients of neoadjuvant therapy pointed to a path of subsequent stratification by cHR and histological grade, also enabling grouping of luminal breast cancer patients with similar prognosis for DMFS (cHR ≤ 4+ G2 or G3 versus triple-negative, adjusted HaR: 0.703 (0.415-1.189), p = 0.189) and OS (cHR ≤4+ G2 or G3 versus triple-negative, adjusted HaR: 0.662 (0.403-1.088), p = 0.104).The semi-quantitative expression of both cHR, Ki-67 proliferation index and histological grade can identify luminal breast cancer patients at greater risk of developing metastasis and death when combined in a hierarchical fashion, and could be useful for a better prognosis stratification in services from low- and middle-income countries." @default.
- W4225381327 created "2022-05-05" @default.
- W4225381327 creator A5015485121 @default.
- W4225381327 creator A5025339853 @default.
- W4225381327 creator A5025918765 @default.
- W4225381327 creator A5032641897 @default.
- W4225381327 creator A5039911226 @default.
- W4225381327 creator A5043799110 @default.
- W4225381327 creator A5063698368 @default.
- W4225381327 creator A5089381019 @default.
- W4225381327 date "2022-05-04" @default.
- W4225381327 modified "2023-10-14" @default.
- W4225381327 title "A hierarchical approach to combine histological grade and immunohistochemical factors to identify high-risk luminal breast cancers" @default.
- W4225381327 cites W1561569880 @default.
- W4225381327 cites W1892496998 @default.
- W4225381327 cites W1926244529 @default.
- W4225381327 cites W1961026612 @default.
- W4225381327 cites W1967244419 @default.
- W4225381327 cites W1976173969 @default.
- W4225381327 cites W1977295091 @default.
- W4225381327 cites W1986826544 @default.
- W4225381327 cites W2004562250 @default.
- W4225381327 cites W2010871781 @default.
- W4225381327 cites W2019151692 @default.
- W4225381327 cites W2031393050 @default.
- W4225381327 cites W2037176714 @default.
- W4225381327 cites W2044481915 @default.
- W4225381327 cites W2044702943 @default.
- W4225381327 cites W2053741141 @default.
- W4225381327 cites W2056014037 @default.
- W4225381327 cites W2063007022 @default.
- W4225381327 cites W2085677203 @default.
- W4225381327 cites W2087905904 @default.
- W4225381327 cites W2097255042 @default.
- W4225381327 cites W2104091109 @default.
- W4225381327 cites W2105882193 @default.
- W4225381327 cites W2113344831 @default.
- W4225381327 cites W2117775530 @default.
- W4225381327 cites W2118413367 @default.
- W4225381327 cites W2125702566 @default.
- W4225381327 cites W2126540255 @default.
- W4225381327 cites W2128920415 @default.
- W4225381327 cites W2128985829 @default.
- W4225381327 cites W2132619562 @default.
- W4225381327 cites W2132893003 @default.
- W4225381327 cites W2137570502 @default.
- W4225381327 cites W2144183889 @default.
- W4225381327 cites W2146527187 @default.
- W4225381327 cites W2150134401 @default.
- W4225381327 cites W2150533948 @default.
- W4225381327 cites W2152121590 @default.
- W4225381327 cites W2160377567 @default.
- W4225381327 cites W2160450758 @default.
- W4225381327 cites W2160723007 @default.
- W4225381327 cites W2161109798 @default.
- W4225381327 cites W2163045991 @default.
- W4225381327 cites W2172045238 @default.
- W4225381327 cites W2173858545 @default.
- W4225381327 cites W2205503125 @default.
- W4225381327 cites W2259802687 @default.
- W4225381327 cites W2329942918 @default.
- W4225381327 cites W2397800570 @default.
- W4225381327 cites W2517421365 @default.
- W4225381327 cites W2529914518 @default.
- W4225381327 cites W2531506996 @default.
- W4225381327 cites W2537305086 @default.
- W4225381327 cites W2560367415 @default.
- W4225381327 cites W2560579151 @default.
- W4225381327 cites W2573152477 @default.
- W4225381327 cites W2734602083 @default.
- W4225381327 cites W2754401034 @default.
- W4225381327 cites W2765912935 @default.
- W4225381327 cites W2768503773 @default.
- W4225381327 cites W2782941313 @default.
- W4225381327 cites W2788523770 @default.
- W4225381327 cites W2789698864 @default.
- W4225381327 cites W2792607373 @default.
- W4225381327 cites W2800158081 @default.
- W4225381327 cites W2803725301 @default.
- W4225381327 cites W2805734855 @default.
- W4225381327 cites W2898503088 @default.
- W4225381327 cites W2899496983 @default.
- W4225381327 cites W2944050969 @default.
- W4225381327 cites W2948923376 @default.
- W4225381327 cites W2954186331 @default.
- W4225381327 cites W2959904259 @default.
- W4225381327 cites W2965857754 @default.
- W4225381327 cites W2967213355 @default.
- W4225381327 cites W2969537103 @default.
- W4225381327 cites W2971304898 @default.
- W4225381327 cites W2997147953 @default.
- W4225381327 cites W2999400187 @default.
- W4225381327 cites W3011067624 @default.
- W4225381327 cites W3022536633 @default.
- W4225381327 cites W3046704184 @default.
- W4225381327 cites W3103148690 @default.
- W4225381327 cites W3116128628 @default.
- W4225381327 cites W3127186602 @default.
- W4225381327 cites W3128646645 @default.
- W4225381327 cites W3137030093 @default.