Matches in SemOpenAlex for { <https://semopenalex.org/work/W4225388230> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W4225388230 abstract "Hepatic cirrhosis is associated to circulatory abnormalities. A combination of vasodilation, lower plasmatic protein content and splanchnic venous stagnation leads to hypovolemia, which in turn stimulates the renin-angiotensin-aldosterone system (RAAS). Advanced stages of the disease cause renal failure and subsequent impaired K+ homeostasis. It has been proposed that the distal colon undergoes functional remodeling during renal failure, in particular by aldosterone-driven increased K+ excretion. In this study, we compared the transcriptional response of aldosterone target genes in the rat distal colon under two models of increased circulating aldosterone, one with concomitant RAAS activation, and in a model of hepatic cirrhosis. We examined known aldosterone-regulated transcripts involved in corticosteroid signaling and transepithelial ion transport. In addition, we included new aldosterone-regulated genes identified via whole transcriptome analysis. Our comparison revealed that multiple aldosterone-target genes are upregulated during cirrhosis in the rat distal colon. This upregulation is more prominent in animals showing decompensated cirrhosis. Epithelial Na+ channel (ENaC) β and γ subunit expression correlated positively with plasma aldosterone concentration and negatively with glomerular filtration rate. Altogether, our results demonstrate cirrhosis-induced ion transporter subunit expression remodeling, a change that correlated well with the severity of the disease and suggested a role for aldosterone in the process. The expression of a subset of these genes was then tested in distal colon biopsies obtained from patients showing decompensated cirrhosis and treated or not with mineralocorticoid receptor inhibitor spironolactone. Preliminary results show decreased expression of ENaC subunits and channel regulator K-ras in patients treated with spironolactone. We conclude that cirrhosis progression towards a decompensated state with hypovolemia induces remodeling of distal colon ion transporter expression to match a decaying kidney function." @default.
- W4225388230 created "2022-05-05" @default.
- W4225388230 creator A5001318714 @default.
- W4225388230 creator A5004190668 @default.
- W4225388230 creator A5010231452 @default.
- W4225388230 creator A5043362690 @default.
- W4225388230 creator A5084851102 @default.
- W4225388230 creator A5087807822 @default.
- W4225388230 date "2022-05-01" @default.
- W4225388230 modified "2023-09-23" @default.
- W4225388230 title "Transcriptional response of aldosterone target genes in the rat and human distal colon during hepatic cirrhosis" @default.
- W4225388230 doi "https://doi.org/10.1096/fasebj.2022.36.s1.r3360" @default.
- W4225388230 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35560515" @default.
- W4225388230 hasPublicationYear "2022" @default.
- W4225388230 type Work @default.
- W4225388230 citedByCount "0" @default.
- W4225388230 crossrefType "journal-article" @default.
- W4225388230 hasAuthorship W4225388230A5001318714 @default.
- W4225388230 hasAuthorship W4225388230A5004190668 @default.
- W4225388230 hasAuthorship W4225388230A5010231452 @default.
- W4225388230 hasAuthorship W4225388230A5043362690 @default.
- W4225388230 hasAuthorship W4225388230A5084851102 @default.
- W4225388230 hasAuthorship W4225388230A5087807822 @default.
- W4225388230 hasConcept C104317684 @default.
- W4225388230 hasConcept C126322002 @default.
- W4225388230 hasConcept C127561419 @default.
- W4225388230 hasConcept C134018914 @default.
- W4225388230 hasConcept C178790620 @default.
- W4225388230 hasConcept C185592680 @default.
- W4225388230 hasConcept C189135053 @default.
- W4225388230 hasConcept C2776069600 @default.
- W4225388230 hasConcept C2776379505 @default.
- W4225388230 hasConcept C2777214474 @default.
- W4225388230 hasConcept C2778525890 @default.
- W4225388230 hasConcept C537181965 @default.
- W4225388230 hasConcept C55493867 @default.
- W4225388230 hasConcept C6507245 @default.
- W4225388230 hasConcept C71924100 @default.
- W4225388230 hasConcept C86803240 @default.
- W4225388230 hasConceptScore W4225388230C104317684 @default.
- W4225388230 hasConceptScore W4225388230C126322002 @default.
- W4225388230 hasConceptScore W4225388230C127561419 @default.
- W4225388230 hasConceptScore W4225388230C134018914 @default.
- W4225388230 hasConceptScore W4225388230C178790620 @default.
- W4225388230 hasConceptScore W4225388230C185592680 @default.
- W4225388230 hasConceptScore W4225388230C189135053 @default.
- W4225388230 hasConceptScore W4225388230C2776069600 @default.
- W4225388230 hasConceptScore W4225388230C2776379505 @default.
- W4225388230 hasConceptScore W4225388230C2777214474 @default.
- W4225388230 hasConceptScore W4225388230C2778525890 @default.
- W4225388230 hasConceptScore W4225388230C537181965 @default.
- W4225388230 hasConceptScore W4225388230C55493867 @default.
- W4225388230 hasConceptScore W4225388230C6507245 @default.
- W4225388230 hasConceptScore W4225388230C71924100 @default.
- W4225388230 hasConceptScore W4225388230C86803240 @default.
- W4225388230 hasIssue "S1" @default.
- W4225388230 hasLocation W42253882301 @default.
- W4225388230 hasLocation W42253882302 @default.
- W4225388230 hasOpenAccess W4225388230 @default.
- W4225388230 hasPrimaryLocation W42253882301 @default.
- W4225388230 hasRelatedWork W1971595373 @default.
- W4225388230 hasRelatedWork W1993396385 @default.
- W4225388230 hasRelatedWork W2019725123 @default.
- W4225388230 hasRelatedWork W2037408526 @default.
- W4225388230 hasRelatedWork W2072829430 @default.
- W4225388230 hasRelatedWork W2167567832 @default.
- W4225388230 hasRelatedWork W2312942238 @default.
- W4225388230 hasRelatedWork W2322243425 @default.
- W4225388230 hasRelatedWork W2589899659 @default.
- W4225388230 hasRelatedWork W32200126 @default.
- W4225388230 hasVolume "36" @default.
- W4225388230 isParatext "false" @default.
- W4225388230 isRetracted "false" @default.
- W4225388230 workType "article" @default.