Matches in SemOpenAlex for { <https://semopenalex.org/work/W4225407242> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W4225407242 abstract "It is evident that both aged and diseased skeletal muscle exhibit interesting neuromuscular dynamics, characterized by changes in morphology and functionality of the synapse. Although they display a high regenerative capacity, skeletal muscles are still susceptible to nervous system perturbations and impacts of aging. Aged neuromuscular junctions (NMJs) demonstrate a diseased phenotype following some form of muscle atrophy, indicating the presence of paracrine signaling between myofibers and neuronal cells. In this study, we investigated differences in neuromuscular dynamics in injured and aged skeletal muscle using whole-mount immunostaining and imaging. It has previously been shown that disruption of one component of the muscle microenvironment, such as vasculature, disrupts the structure of NMJs, however it is unclear if aged skeletal muscle experiences similar changes. We hypothesized that both aged and injured NMJs would display similar morphological dynamics, characterized by denervation and fragmentation of postsynaptic acetylcholine receptors (AChRs). We demonstrated that aged and injured NMJs exhibit fragmentation of AChRs, Wallerian degeneration of the presynaptic motor neurons, decreased overlap of pre- and post-synaptic sides, and decreased area of AChR clusters. Due to the prevalence of neuromuscular disorders in the aging population, it is pertinent to understand nerve-muscle interactions in the healthy aging state in order to hypothesize how these dynamics may be altered in the age-induced injury states. Ultimately, this will allow us to better comprehend the molecular and cellular mechanisms that are responsible for neuromuscular degeneration in order to develop strategies to improve mobility and quality of life." @default.
- W4225407242 created "2022-05-05" @default.
- W4225407242 creator A5012261629 @default.
- W4225407242 creator A5027481799 @default.
- W4225407242 creator A5047148209 @default.
- W4225407242 creator A5053871036 @default.
- W4225407242 creator A5070371898 @default.
- W4225407242 creator A5073860745 @default.
- W4225407242 creator A5084217860 @default.
- W4225407242 creator A5085399627 @default.
- W4225407242 date "2022-05-01" @default.
- W4225407242 modified "2023-09-27" @default.
- W4225407242 title "Neuromuscular Synapse Dynamics in Aged and Injured Skeletal Muscle" @default.
- W4225407242 doi "https://doi.org/10.1096/fasebj.2022.36.s1.r3239" @default.
- W4225407242 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35556304" @default.
- W4225407242 hasPublicationYear "2022" @default.
- W4225407242 type Work @default.
- W4225407242 citedByCount "0" @default.
- W4225407242 crossrefType "journal-article" @default.
- W4225407242 hasAuthorship W4225407242A5012261629 @default.
- W4225407242 hasAuthorship W4225407242A5027481799 @default.
- W4225407242 hasAuthorship W4225407242A5047148209 @default.
- W4225407242 hasAuthorship W4225407242A5053871036 @default.
- W4225407242 hasAuthorship W4225407242A5070371898 @default.
- W4225407242 hasAuthorship W4225407242A5073860745 @default.
- W4225407242 hasAuthorship W4225407242A5084217860 @default.
- W4225407242 hasAuthorship W4225407242A5085399627 @default.
- W4225407242 hasConcept C105702510 @default.
- W4225407242 hasConcept C127445978 @default.
- W4225407242 hasConcept C169760540 @default.
- W4225407242 hasConcept C170493617 @default.
- W4225407242 hasConcept C197341189 @default.
- W4225407242 hasConcept C2776805190 @default.
- W4225407242 hasConcept C2777240379 @default.
- W4225407242 hasConcept C2779959927 @default.
- W4225407242 hasConcept C2908647359 @default.
- W4225407242 hasConcept C55493867 @default.
- W4225407242 hasConcept C71924100 @default.
- W4225407242 hasConcept C80161118 @default.
- W4225407242 hasConcept C86803240 @default.
- W4225407242 hasConcept C99454951 @default.
- W4225407242 hasConceptScore W4225407242C105702510 @default.
- W4225407242 hasConceptScore W4225407242C127445978 @default.
- W4225407242 hasConceptScore W4225407242C169760540 @default.
- W4225407242 hasConceptScore W4225407242C170493617 @default.
- W4225407242 hasConceptScore W4225407242C197341189 @default.
- W4225407242 hasConceptScore W4225407242C2776805190 @default.
- W4225407242 hasConceptScore W4225407242C2777240379 @default.
- W4225407242 hasConceptScore W4225407242C2779959927 @default.
- W4225407242 hasConceptScore W4225407242C2908647359 @default.
- W4225407242 hasConceptScore W4225407242C55493867 @default.
- W4225407242 hasConceptScore W4225407242C71924100 @default.
- W4225407242 hasConceptScore W4225407242C80161118 @default.
- W4225407242 hasConceptScore W4225407242C86803240 @default.
- W4225407242 hasConceptScore W4225407242C99454951 @default.
- W4225407242 hasFunder F4320306078 @default.
- W4225407242 hasFunder F4320332161 @default.
- W4225407242 hasIssue "S1" @default.
- W4225407242 hasLocation W42254072421 @default.
- W4225407242 hasLocation W42254072422 @default.
- W4225407242 hasOpenAccess W4225407242 @default.
- W4225407242 hasPrimaryLocation W42254072421 @default.
- W4225407242 hasRelatedWork W1616257688 @default.
- W4225407242 hasRelatedWork W2047031814 @default.
- W4225407242 hasRelatedWork W2600642499 @default.
- W4225407242 hasRelatedWork W3046057553 @default.
- W4225407242 hasRelatedWork W3084345651 @default.
- W4225407242 hasRelatedWork W3193437364 @default.
- W4225407242 hasRelatedWork W3215378016 @default.
- W4225407242 hasRelatedWork W4206934756 @default.
- W4225407242 hasRelatedWork W4225407242 @default.
- W4225407242 hasRelatedWork W4284971280 @default.
- W4225407242 hasVolume "36" @default.
- W4225407242 isParatext "false" @default.
- W4225407242 isRetracted "false" @default.
- W4225407242 workType "article" @default.