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• W4225408406 abstract "Risk of overdose, suicide, and other adverse outcomes are elevated among sub-populations prescribed opioid analgesics. To address this, the Veterans Health Administration (VHA) developed the Stratification Tool for Opioid Risk Mitigation (STORM)—a provider-facing dashboard that utilizes predictive analytics to stratify patients prescribed opioids based on risk for overdose/suicide. To evaluate the impact of the case review mandate on serious adverse events (SAEs) and all-cause mortality among high-risk Veterans. A 23-month stepped-wedge cluster randomized controlled trial in all 140 VHA medical centers between 2018 and 2020. A total of 44,042 patients actively prescribed opioid analgesics with high STORM risk scores (i.e., percentiles 1% to 5%) for an overdose or suicide-related event. A mandate requiring providers to perform case reviews on opioid analgesic-prescribed patients at high risk of overdose/suicide. Nine serious adverse events (SAEs), case review completion, number of risk mitigation strategies, and all-cause mortality. Mandated review inclusion was associated with a significant decrease in all-cause mortality within 4 months of inclusion (OR: 0.78; 95% CI: 0.65–0.94). There was no detectable effect on SAEs. Stepped-wedge analyses found that mandated review patients were five times more likely to receive a case review than non-mandated patients with similar risk (OR: 5.1; 95% CI: 3.64–7.23) and received more risk mitigation strategies than non-mandated patients (0.498; CI: 0.39–0.61). Among VHA patients prescribed opioid analgesics, identifying high risk patients and mandating they receive an interdisciplinary case review was associated with a decrease in all-cause mortality. Results suggest that providers can leverage predictive analytic-targeted population health approaches and interdisciplinary collaboration to improve patient outcomes. ISRCTN16012111" @default.
• W4225408406 created "2022-05-05" @default.
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• W4225408406 date "2022-05-02" @default.
• W4225408406 modified "2023-10-17" @default.
• W4225408406 title "Effect of a Predictive Analytics-Targeted Program in Patients on Opioids: a Stepped-Wedge Cluster Randomized Controlled Trial" @default.
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• W4225408406 doi "https://doi.org/10.1007/s11606-022-07617-y" @default.
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