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• W4225409666 abstract "Topiramate-induced acute angle closure (TiAAC) is a potentially vision-threatening side effect of topiramate (TPM) use. The purpose of this article is to review demographic characteristics, clinical features, and management options of TiAAC. A systematic literature search of all reported cases and case series of TiAAC was conducted in the following search engines: PubMed, Web of Science, Google Scholar, Elsevier, and EBSCO. Seventy-three publications describing 77 cases were included. 58 (75.3%) patients were female, and the mean age was 34.88 ± 11.21 years (range, 7-57). The most commonly reported indication of TPM use was migraine headache (59.7%), and the mean duration from starting treatment until the onset of angle closure was 14.1 ± 31.5 days. All cases were managed by immediate cessation of TPM and topical therapy. In addition, systemic medications (carbonic anhydrase inhibitors, hyperosmotic agents, and steroids) were used in 51 patients (66.2%). A laser and/or surgical intervention was performed in 10 patients (13%). After commencement of treatment, the mean duration until the resolution of TiAAC was 3.9 ± 3.6 days (range, 1-18). The findings of our study present a summary of the current body of evidence provided by case reports and case series on TiAAC. In conclusion, the onset of angle closure following TPM use peaks at 2 weeks after initiating treatment, and in most cases, successful management can be achieved by discontinuing TPM and initiating appropriate medical therapy." @default.
• W4225409666 created "2022-05-05" @default.
• W4225409666 creator A5036858493 @default.
• W4225409666 creator A5056769625 @default.
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• W4225409666 date "2022-01-01" @default.
• W4225409666 modified "2023-10-01" @default.
• W4225409666 title "Topiramate-induced acute angle closure: A systematic review of case reports and case series" @default.
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• W4225409666 doi "https://doi.org/10.4103/ijo.ijo_2134_21" @default.
• W4225409666 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35502014" @default.
• W4225409666 hasPublicationYear "2022" @default.
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