Matches in SemOpenAlex for { <https://semopenalex.org/work/W4225410198> ?p ?o ?g. }
- W4225410198 abstract "The kinetics of NKG2C+ adaptive natural killer (ANK) cells and NKG2A+inhibitory NK (iNK) cells with respect to the incidence of SARS-CoV-2 infection were studied for 6 months in a cohort of healthcare workers following the administration of the heat-killed Mycobacterium w (Mw group) in comparison to a control group. In both groups, corona virus disease 2019 (COVID-19) correlated with lower NKG2C+ANK cells at baseline. There was a significant upregulation of NKG2C expression and IFN-γ release in the Mw group (p=0.0009), particularly in those with a lower baseline NKG2C expression, along with the downregulation of iNK cells (p<0.0001). This translated to a significant reduction in the incidence and severity of COVID-19 in the Mw group (incidence risk ratio-0.15, p=0.0004). RNA-seq analysis at 6 months showed an upregulation of the ANK pathway genes and an enhanced ANK-mediated antibody-dependent cellular cytotoxicity (ADCC) signature. Thus, Mw was observed to have a salutary impact on the ANK cell profile and a long-term upregulation of ANK-ADCC pathways, which could have provided protection against COVID-19 in a non-immune high-risk population." @default.
- W4225410198 created "2022-05-05" @default.
- W4225410198 creator A5005404304 @default.
- W4225410198 creator A5010149135 @default.
- W4225410198 creator A5028360495 @default.
- W4225410198 creator A5039517708 @default.
- W4225410198 creator A5046024720 @default.
- W4225410198 creator A5046265322 @default.
- W4225410198 creator A5065206355 @default.
- W4225410198 creator A5065990775 @default.
- W4225410198 creator A5077775706 @default.
- W4225410198 creator A5083038287 @default.
- W4225410198 creator A5083124988 @default.
- W4225410198 date "2022-05-04" @default.
- W4225410198 modified "2023-09-26" @default.
- W4225410198 title "Impact of an Immune Modulator Mycobacterium-w on Adaptive Natural Killer Cells and Protection Against COVID-19" @default.
- W4225410198 cites W14494190 @default.
- W4225410198 cites W1839618459 @default.
- W4225410198 cites W1970591872 @default.
- W4225410198 cites W1971157896 @default.
- W4225410198 cites W1972452655 @default.
- W4225410198 cites W1982933284 @default.
- W4225410198 cites W2005283688 @default.
- W4225410198 cites W2014522512 @default.
- W4225410198 cites W2017275347 @default.
- W4225410198 cites W2019278343 @default.
- W4225410198 cites W2027266738 @default.
- W4225410198 cites W2046964385 @default.
- W4225410198 cites W2050435702 @default.
- W4225410198 cites W2051890542 @default.
- W4225410198 cites W2062147513 @default.
- W4225410198 cites W2064981157 @default.
- W4225410198 cites W2071361667 @default.
- W4225410198 cites W2124872606 @default.
- W4225410198 cites W2151186939 @default.
- W4225410198 cites W2160092751 @default.
- W4225410198 cites W2189893583 @default.
- W4225410198 cites W2417756147 @default.
- W4225410198 cites W2510118597 @default.
- W4225410198 cites W2529084851 @default.
- W4225410198 cites W2777691985 @default.
- W4225410198 cites W2799421556 @default.
- W4225410198 cites W2887119890 @default.
- W4225410198 cites W2888029145 @default.
- W4225410198 cites W2938281770 @default.
- W4225410198 cites W2972078066 @default.
- W4225410198 cites W2972188699 @default.
- W4225410198 cites W2990092235 @default.
- W4225410198 cites W3008028633 @default.
- W4225410198 cites W3016233057 @default.
- W4225410198 cites W3033026453 @default.
- W4225410198 cites W3041881467 @default.
- W4225410198 cites W3042245246 @default.
- W4225410198 cites W3043902756 @default.
- W4225410198 cites W3044986275 @default.
- W4225410198 cites W3080995641 @default.
- W4225410198 cites W3094432307 @default.
- W4225410198 cites W3111019733 @default.
- W4225410198 cites W3111590711 @default.
- W4225410198 cites W3114208348 @default.
- W4225410198 cites W3118772039 @default.
- W4225410198 cites W3123419925 @default.
- W4225410198 cites W3129926272 @default.
- W4225410198 cites W3134611893 @default.
- W4225410198 cites W3134803200 @default.
- W4225410198 cites W3138261380 @default.
- W4225410198 cites W3166184636 @default.
- W4225410198 cites W3200303519 @default.
- W4225410198 cites W4205891897 @default.
- W4225410198 cites W4206628422 @default.
- W4225410198 cites W4225854071 @default.
- W4225410198 doi "https://doi.org/10.3389/fimmu.2022.887230" @default.
- W4225410198 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35603154" @default.
- W4225410198 hasPublicationYear "2022" @default.
- W4225410198 type Work @default.
- W4225410198 citedByCount "4" @default.
- W4225410198 countsByYear W42254101982022 @default.
- W4225410198 countsByYear W42254101982023 @default.
- W4225410198 crossrefType "journal-article" @default.
- W4225410198 hasAuthorship W4225410198A5005404304 @default.
- W4225410198 hasAuthorship W4225410198A5010149135 @default.
- W4225410198 hasAuthorship W4225410198A5028360495 @default.
- W4225410198 hasAuthorship W4225410198A5039517708 @default.
- W4225410198 hasAuthorship W4225410198A5046024720 @default.
- W4225410198 hasAuthorship W4225410198A5046265322 @default.
- W4225410198 hasAuthorship W4225410198A5065206355 @default.
- W4225410198 hasAuthorship W4225410198A5065990775 @default.
- W4225410198 hasAuthorship W4225410198A5077775706 @default.
- W4225410198 hasAuthorship W4225410198A5083038287 @default.
- W4225410198 hasAuthorship W4225410198A5083124988 @default.
- W4225410198 hasBestOaLocation W42254101981 @default.
- W4225410198 hasConcept C104317684 @default.
- W4225410198 hasConcept C127561419 @default.
- W4225410198 hasConcept C159047783 @default.
- W4225410198 hasConcept C159654299 @default.
- W4225410198 hasConcept C185592680 @default.
- W4225410198 hasConcept C203014093 @default.
- W4225410198 hasConcept C40677261 @default.
- W4225410198 hasConcept C542903549 @default.
- W4225410198 hasConcept C55493867 @default.