Matches in SemOpenAlex for { <https://semopenalex.org/work/W4225415029> ?p ?o ?g. }
Showing items 1 to 68 of
68
with 100 items per page.
- W4225415029 abstract "Dictyostelium discoideum is a social amoeba commonly used as a model organism in cellular migration studies. Dictyostelium adhesion is mediated by nonspecific interactions, such as Van der Waals forces, as well as specific protein-mediated interactions between the cell and the substrate. Since adhesive properties of this organism affect its motility, finding ways to manipulate its nonspecific or specific interactions can be useful for future migration experiments. We tested the effects of bovine serum albumin (BSA), which is known to affect nonspecific binding via its interference with electrostatic interactions, on Dictyostelium adhesion. Bacterially-grown wild-type cells had increased adhesion when plated on 3% BSA, while axenically-grown cells exhibited a decrease in adhesion on BSA. To explore why BSA has differential effects on adhesion of Dictyostelium grown under different conditions we tested adhesion of cells lacking one of the specific mediators of attachment, Talin A (TalA). Unlike wild-type cells, both axenically and bacterially-grown TalA-null cells had decreased adhesion on BSA. These data suggest that BSA effects on adhesion may be dependent on TalA in bacterially-grown cells. Alternatively, since TalA-null cells have an impaired ability to phagocytose, they may behave more like axenically-grown cells even when grown on bacteria. In this case, differential effects of BSA may be due to the inherent differences in the adhesion mechanism of cells grown under axenic vs. bacterially-fed conditions. We are currently examining these possibilities." @default.
- W4225415029 created "2022-05-05" @default.
- W4225415029 creator A5030555149 @default.
- W4225415029 creator A5082168374 @default.
- W4225415029 date "2022-05-01" @default.
- W4225415029 modified "2023-10-16" @default.
- W4225415029 title "Investigation of the Adhesion‐Modulating Properties of Bovine Serum Albumin (BSA) in <i>Dictyostelium discoideum</i>" @default.
- W4225415029 doi "https://doi.org/10.1096/fasebj.2022.36.s1.l8123" @default.
- W4225415029 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35553759" @default.
- W4225415029 hasPublicationYear "2022" @default.
- W4225415029 type Work @default.
- W4225415029 citedByCount "0" @default.
- W4225415029 crossrefType "journal-article" @default.
- W4225415029 hasAuthorship W4225415029A5030555149 @default.
- W4225415029 hasAuthorship W4225415029A5082168374 @default.
- W4225415029 hasConcept C104317684 @default.
- W4225415029 hasConcept C12554922 @default.
- W4225415029 hasConcept C178790620 @default.
- W4225415029 hasConcept C185592680 @default.
- W4225415029 hasConcept C2775889303 @default.
- W4225415029 hasConcept C2775969001 @default.
- W4225415029 hasConcept C2776172558 @default.
- W4225415029 hasConcept C2778265057 @default.
- W4225415029 hasConcept C523546767 @default.
- W4225415029 hasConcept C54355233 @default.
- W4225415029 hasConcept C55493867 @default.
- W4225415029 hasConcept C58207958 @default.
- W4225415029 hasConcept C84416704 @default.
- W4225415029 hasConcept C85789140 @default.
- W4225415029 hasConcept C86803240 @default.
- W4225415029 hasConcept C86807702 @default.
- W4225415029 hasConcept C95444343 @default.
- W4225415029 hasConceptScore W4225415029C104317684 @default.
- W4225415029 hasConceptScore W4225415029C12554922 @default.
- W4225415029 hasConceptScore W4225415029C178790620 @default.
- W4225415029 hasConceptScore W4225415029C185592680 @default.
- W4225415029 hasConceptScore W4225415029C2775889303 @default.
- W4225415029 hasConceptScore W4225415029C2775969001 @default.
- W4225415029 hasConceptScore W4225415029C2776172558 @default.
- W4225415029 hasConceptScore W4225415029C2778265057 @default.
- W4225415029 hasConceptScore W4225415029C523546767 @default.
- W4225415029 hasConceptScore W4225415029C54355233 @default.
- W4225415029 hasConceptScore W4225415029C55493867 @default.
- W4225415029 hasConceptScore W4225415029C58207958 @default.
- W4225415029 hasConceptScore W4225415029C84416704 @default.
- W4225415029 hasConceptScore W4225415029C85789140 @default.
- W4225415029 hasConceptScore W4225415029C86803240 @default.
- W4225415029 hasConceptScore W4225415029C86807702 @default.
- W4225415029 hasConceptScore W4225415029C95444343 @default.
- W4225415029 hasIssue "S1" @default.
- W4225415029 hasLocation W42254150291 @default.
- W4225415029 hasLocation W42254150292 @default.
- W4225415029 hasOpenAccess W4225415029 @default.
- W4225415029 hasPrimaryLocation W42254150291 @default.
- W4225415029 hasRelatedWork W2012914498 @default.
- W4225415029 hasRelatedWork W2090483107 @default.
- W4225415029 hasRelatedWork W2103168312 @default.
- W4225415029 hasRelatedWork W2109747402 @default.
- W4225415029 hasRelatedWork W2164386856 @default.
- W4225415029 hasRelatedWork W2314096879 @default.
- W4225415029 hasRelatedWork W2790288676 @default.
- W4225415029 hasRelatedWork W3044244615 @default.
- W4225415029 hasRelatedWork W4225415029 @default.
- W4225415029 hasRelatedWork W2166546747 @default.
- W4225415029 hasVolume "36" @default.
- W4225415029 isParatext "false" @default.
- W4225415029 isRetracted "false" @default.
- W4225415029 workType "article" @default.