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- W4225421486 abstract "Abstract Clinically, early brain injury (EBI) which refers to the acute injuries to the whole brain in phase of the first 72 h following subarachnoid hemorrhage (SAH), is intensely investigated to improve neurological and psychological function. It had been revealed that metformin (Met) possesses extensive functions, all can be showed in anti-inflammatory, antiapoptotic and anti-tumor activities. Here, to investigate the anti-inflammatory effect of Met, patients with SAH undergoing embolization of intracranial aneurysm in the Neurosurgery Department of the Jinling Hospital, were reviewed for a clinical retrospective analysis from January 2013 to November 2019. Meanwhile, we examined the effects of Met on the inflammatory factors and apoptosis after SAH and the explanation mechanisms of action in vivo. Met administration 2days before SAH ameliorated cerebral inflammation, brain edema, and neuronal death and improved neurologic function. Collectively, these results indicate that Met reduces the inflammatory response and alleviates early brain injury after SAH, primarily by increasing SIRT1 levels and inhibiting inflammation factors." @default.
- W4225421486 created "2022-05-05" @default.
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- W4225421486 date "2022-05-04" @default.
- W4225421486 modified "2023-09-27" @default.
- W4225421486 title "Metformin mitigates early brain injury after subarachnoid hemorrhage primarily by increasing SIRT1 and inhibiting inflammation factors" @default.
- W4225421486 doi "https://doi.org/10.21203/rs.3.rs-1605033/v1" @default.
- W4225421486 hasPublicationYear "2022" @default.
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