FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4225423393> ?p ?o ?g. }

• W4225423393 abstract "Abstract Background Glutathione S-transferases (GSTs) are a class of important Phase II detoxification enzymes that catalyze the conjugation of glutathione and xenobiotic compounds (environmental carcinogens, pollutants and drugs) to protect against oxidative stress. GSTT1 and GSTM1 genetic polymorphisms have been extensively studied, and null genotypes or homozygous deletions have been reported in various populations. Previous studies have suggested that those who are homozygous null at the GSTM1 or GSTT1 loci are more susceptible and have a higher risk of cancers linked to environmental pollutants and drug-induced toxicity. Our study focused on GSTM1 and GSTT1 null allele frequency in the Doon population of Himachal Pradesh (India) with a comparison across other Inter and Intra-Indian ethnic groups to predict variation in the possible susceptible status. Material and methods Genomic DNA samples were extracted from 297 healthy unrelated individuals by a ReliaPrep™ Blood gDNA Miniprep kit (Promega, USA), and genotyped for allelic variation in GSTM1 and GSTT1 genotypes by multiplex polymerase chain reaction. Fisher's exact test was applied using SPSS.20 to analyze the genotypic distribution of GSTM1 and GSTT1 null alleles in male and female of Doon region (Solan) Himachal Pradesh. Results In our study, the frequency distribution of the homozygous null genotypes of GSTM1 , GSTT1 individually as well as combined was found as 33.3%, 32% and 9%, respectively. Upon gender-wise comparison, a non-significant distribution ( p > 0.05) for null genotypes of GSTM1 (32.8% and 35.4%, OR-0.77, 95% CI 0.42–1.41), GSTT1 (33.2% and 27.7%, OR-1.12, 95% CI 0.63–2.0) individually and combined GSTM1 and GSTT1 (10.8% and 3.7%, OR-0.31, 95% CI 0.07–1.42) were observed in studied population. Conclusions In our studied population, the frequency of GSTM1 null genotypes was found deviated from Inter- and Intra-Indian ethnic groups. However, the frequency of homozygous null type of GSTT1 was not significantly different, when compared to previous Indian studies, comparison with global ethnic groups showed deviation. Thus, our study has highlighted possible susceptibility risk to various xenobiotics in the Doon population of Himachal Pradesh, India." @default.
• W4225423393 created "2022-05-05" @default.
• W4225423393 creator A5007728747 @default.
• W4225423393 creator A5016388346 @default.
• W4225423393 creator A5029056369 @default.
• W4225423393 creator A5032953437 @default.
• W4225423393 creator A5053525357 @default.
• W4225423393 creator A5055375440 @default.
• W4225423393 creator A5090389591 @default.
• W4225423393 date "2022-05-04" @default.
• W4225423393 modified "2023-09-24" @default.
• W4225423393 title "Comparative frequency distribution of glutathione S-transferase mu (GSTM1) and theta (GSTT1) allelic forms in Himachal Pradesh population" @default.
• W4225423393 cites W1750764013 @default.
• W4225423393 cites W1867122246 @default.
• W4225423393 cites W1984978318 @default.
• W4225423393 cites W1991091747 @default.
• W4225423393 cites W1991797758 @default.
• W4225423393 cites W1993490426 @default.
• W4225423393 cites W2010793730 @default.
• W4225423393 cites W2017502829 @default.
• W4225423393 cites W2024631276 @default.
• W4225423393 cites W2027619600 @default.
• W4225423393 cites W2032487617 @default.
• W4225423393 cites W2038880691 @default.
• W4225423393 cites W2047134670 @default.
• W4225423393 cites W2059410642 @default.
• W4225423393 cites W2074621147 @default.
• W4225423393 cites W2089139131 @default.
• W4225423393 cites W2101484223 @default.
• W4225423393 cites W2102044807 @default.
• W4225423393 cites W2105102385 @default.
• W4225423393 cites W2115144412 @default.
• W4225423393 cites W2122623866 @default.
• W4225423393 cites W2125660544 @default.
• W4225423393 cites W2140970860 @default.
• W4225423393 cites W2150586492 @default.
• W4225423393 cites W2157244487 @default.
• W4225423393 cites W2170451142 @default.
• W4225423393 cites W2327128161 @default.
• W4225423393 cites W2336968064 @default.
• W4225423393 cites W2341519109 @default.
• W4225423393 cites W2346056812 @default.
• W4225423393 cites W2765626255 @default.
• W4225423393 cites W2790784861 @default.
• W4225423393 cites W2799621086 @default.
• W4225423393 cites W2970854101 @default.
• W4225423393 cites W2974793850 @default.
• W4225423393 cites W2977218961 @default.
• W4225423393 cites W3087637000 @default.
• W4225423393 cites W4240972893 @default.
• W4225423393 doi "https://doi.org/10.1186/s43042-022-00298-6" @default.
• W4225423393 hasPublicationYear "2022" @default.
• W4225423393 type Work @default.
• W4225423393 citedByCount "2" @default.
• W4225423393 countsByYear W42254233932023 @default.
• W4225423393 crossrefType "journal-article" @default.
• W4225423393 hasAuthorship W4225423393A5007728747 @default.
• W4225423393 hasAuthorship W4225423393A5016388346 @default.
• W4225423393 hasAuthorship W4225423393A5029056369 @default.
• W4225423393 hasAuthorship W4225423393A5032953437 @default.
• W4225423393 hasAuthorship W4225423393A5053525357 @default.
• W4225423393 hasAuthorship W4225423393A5055375440 @default.
• W4225423393 hasAuthorship W4225423393A5090389591 @default.
• W4225423393 hasBestOaLocation W42254233931 @default.
• W4225423393 hasConcept C104317684 @default.
• W4225423393 hasConcept C135763542 @default.
• W4225423393 hasConcept C180754005 @default.
• W4225423393 hasConcept C181199279 @default.
• W4225423393 hasConcept C2776907368 @default.
• W4225423393 hasConcept C2908647359 @default.
• W4225423393 hasConcept C37463918 @default.
• W4225423393 hasConcept C49105822 @default.
• W4225423393 hasConcept C538909803 @default.
• W4225423393 hasConcept C54355233 @default.
• W4225423393 hasConcept C55493867 @default.
• W4225423393 hasConcept C57708383 @default.
• W4225423393 hasConcept C71924100 @default.
• W4225423393 hasConcept C86803240 @default.
• W4225423393 hasConcept C90583042 @default.
• W4225423393 hasConcept C99454951 @default.
• W4225423393 hasConceptScore W4225423393C104317684 @default.
• W4225423393 hasConceptScore W4225423393C135763542 @default.
• W4225423393 hasConceptScore W4225423393C180754005 @default.
• W4225423393 hasConceptScore W4225423393C181199279 @default.
• W4225423393 hasConceptScore W4225423393C2776907368 @default.
• W4225423393 hasConceptScore W4225423393C2908647359 @default.
• W4225423393 hasConceptScore W4225423393C37463918 @default.
• W4225423393 hasConceptScore W4225423393C49105822 @default.
• W4225423393 hasConceptScore W4225423393C538909803 @default.
• W4225423393 hasConceptScore W4225423393C54355233 @default.
• W4225423393 hasConceptScore W4225423393C55493867 @default.
• W4225423393 hasConceptScore W4225423393C57708383 @default.
• W4225423393 hasConceptScore W4225423393C71924100 @default.
• W4225423393 hasConceptScore W4225423393C86803240 @default.
• W4225423393 hasConceptScore W4225423393C90583042 @default.
• W4225423393 hasConceptScore W4225423393C99454951 @default.
• W4225423393 hasIssue "1" @default.
• W4225423393 hasLocation W42254233931 @default.
• W4225423393 hasOpenAccess W4225423393 @default.
• W4225423393 hasPrimaryLocation W42254233931 @default.

• next