Matches in SemOpenAlex for { <https://semopenalex.org/work/W4225463408> ?p ?o ?g. }
- W4225463408 abstract "Vertebrates evolved mechanisms for sodium conservation and gas exchange in conjunction with migration from aquatic to terrestrial habitats. Epithelial Na+ channel (ENaC) function is critical to systems responsible for extracellular fluid homeostasis and gas exchange. ENaC is activated by cleavage at multiple specific extracellular polybasic sites, releasing inhibitory tracts from the channel's α and γ subunits. We found that proximal and distal polybasic tracts in ENaC subunits coevolved, consistent with the dual cleavage requirement for activation observed in mammals. Polybasic tract pairs evolved with the terrestrial migration and the appearance of lungs, coincident with the ENaC activator aldosterone, and appeared independently in the α and γ subunits. In summary, sites within ENaC for protease activation developed in vertebrates when renal Na+ conservation and alveolar gas exchange were required for terrestrial survival." @default.
- W4225463408 created "2022-05-05" @default.
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- W4225463408 date "2022-01-05" @default.
- W4225463408 modified "2023-09-27" @default.
- W4225463408 title "Activation by cleavage of the epithelial Na+ channel α and γ subunits independently coevolved with the vertebrate terrestrial migration" @default.
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- W4225463408 doi "https://doi.org/10.7554/elife.75796" @default.
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