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- W4225485768 abstract "Novel types of the vaccines with high immunogenicity and low risks, including epitope-based vaccines, are sought. Among zoonotic disease, Q fever caused by Coxiella burnetii is an important target due to numerous outbreaks and the pandemic potential. Here we present a synthetic multi-epitope vaccine against Coxiella burnetii. This vaccine was developed using immunoinformatics approach. Antigenic proteins were studied, and five T cell epitopes were selected. Antigenicity, allergenicity, and toxicity of the selected epitopes were evaluated using the VaxiJen 2.0, AllerTOP, and ToxinPred servers, respectively. Selected epitopes were joined in a peptide sequence, with the cholera toxin В subunit (CTXB) as an adjuvant. The affinity of the proposed vaccine to MHCI and II molecules was measured in a molecular docking study. Resultant vaccine has high antigenicity, stability, and a half-life compatible with utilization in vaccination programs. In conclusion, the validated epitope sequences may be used as a potential vaccine to ensure protection against Q fever agent." @default.
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- W4225485768 date "2022-01-01" @default.
- W4225485768 modified "2023-09-27" @default.
- W4225485768 title "Конструирование in silico новой мультиэпитопной кандидатной пептидной вакцины против Q-лихорадки" @default.
- W4225485768 doi "https://doi.org/10.31857/s0026898422010037" @default.
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