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- W4225486985 endingPage "2859" @default.
- W4225486985 startingPage "2833" @default.
- W4225486985 abstract "The occurrence of microorganisms has been confirmed in the tumor microenvironment (TME) of many different organs. Microorganisms (e.g., phage, virus, bacteria, fungi, and protozoa) present in TME modulate TME to inhibit or promote tumor growth in species-dependent manners due to the special physiological and pathological features of each microorganism. Such microorganism-TME interactions have recently been emulated to turn microorganisms into powerful cancer theranostic agents. To facilitate scientists to explore microorganisms-TME interactions further to develop improved cancer theranostics, here we critically review the characteristics of different microorganisms that can be found in TME, their interactions with TME, and their current applications in cancer diagnosis and therapy. Clinical trials of using microorganisms for cancer theranostics are also summarized and discussed. Moreover, the emerging technology of whole-metagenome sequencing that can be employed to precisely determine microbiota spectra is described. Such technology enables scientists to gain an in-depth understanding of the species and distributions of microorganisms in TME. Therefore, scientists now have new tools to identify microorganisms (either naturally present in or introduced into TME) that can be used as effective probes, monitors, vaccines, or drugs for potentially advancing cancer theranostics to clinical applications." @default.
- W4225486985 created "2022-05-05" @default.
- W4225486985 creator A5022252196 @default.
- W4225486985 creator A5036460516 @default.
- W4225486985 creator A5050048856 @default.
- W4225486985 creator A5051217512 @default.
- W4225486985 creator A5057085287 @default.
- W4225486985 creator A5061630101 @default.
- W4225486985 creator A5064747233 @default.
- W4225486985 creator A5080846435 @default.
- W4225486985 date "2022-01-01" @default.
- W4225486985 modified "2023-09-26" @default.
- W4225486985 title "Emulating interactions between microorganisms and tumor microenvironment to develop cancer theranostics" @default.
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