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- W4225495532 abstract "A recent article by Magusali et al.1 in Brain described the genetic association of oligoadenylate synthetase 1 (OAS1) polymorphism rs1131454 with a predisposition to Alzheimer’s disease. Subjects carrying the ‘G’ allele were protected against the development of Alzheimer’s disease (odds ratio = 0.82, P = 0.0082) in the UK population. Furthermore, the authors showed that moderate levels of OAS1 had a strong anti-inflammatory effect, and that it could be an important molecule in the pathogenesis of Alzheimer’s disease. Although the report demonstrated the genetic association of the OAS1 rs1131454 polymorphism with Alzheimer’s disease by including a decent number of samples, information from other populations was lacking. To validate the findings from Magusali et al.,1 we performed an epidemiological correlation analysis in the worldwide population on the possible link between rs1131454 frequency and the prevalence and incidence of Alzheimer’s disease. Online resources, including the Single Nucleotide Polymorphism (dbSNP) and 1000 Genomes databases, were explored to determine the prevalence of rs1131454 in the healthy population worldwide. Details are shown in Table 1. The rs1131454 allele frequencies data were available from 29 countries, namely Bangladesh, Barbados, China, Colombia, Cuba, Denmark, Dominica, Estonia, Finland, Gambia, India, Italy, Japan, Kenya, Korean, Mexican, Netherlands, Nigeria, Pakistan, Peru, Puerto Rico, Sierra Leone, Spain, Sri Lanka, UK, US/California, Vietnam, Sweden and Qatar. The G allele had a prevalence ranging from 15.29% in Peru to 89.13% in Nigeria." @default.
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- W4225495532 date "2022-04-06" @default.
- W4225495532 modified "2023-09-28" @default.
- W4225495532 title "<i>OAS1</i> rs1131454 genetic variant is associated with Alzheimer’s disease: an epidemiological analysis" @default.
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- W4225495532 doi "https://doi.org/10.1093/brain/awac132" @default.
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