Matches in SemOpenAlex for { <https://semopenalex.org/work/W4225499430> ?p ?o ?g. }
- W4225499430 abstract "IntroductionImmunoassays targeting different SARS-CoV-2-specific antibodies are employed for seroprevalence studies. The degree of variability between immunoassays targeting anti-nucleocapsid (anti-NP; the majority) vs the potentially neutralising anti-spike antibodies (including anti-receptor-binding domain; anti-RBD), particularly in mild or asymptomatic disease, remains unclear.AimsWe aimed to explore variability in anti-NP and anti-RBD antibody detectability following mild symptomatic or asymptomatic SARS-CoV-2 infection and analyse antibody response for correlation with symptomatology.MethodsA multicentre prospective cross-sectional study was undertaken (April-July 2020). Paired serum samples were tested for anti-NP and anti-RBD IgG antibodies and reactivity expressed as binding ratios (BR). Multivariate linear regression was performed analysing age, sex, time since onset, symptomatology, anti-NP and anti-RBD antibody BR.ResultsWe included 906 adults. Antibody results (793/906; 87.5%; 95% confidence interval: 85.2-89.6) and BR strongly correlated (ρ = 0.75). PCR-confirmed cases were more frequently identified by anti-RBD (129/130) than anti-NP (123/130). Anti-RBD testing identified 83 of 325 (25.5%) cases otherwise reported as negative for anti-NP. Anti-NP presence (+1.75/unit increase; p < 0.001), fever (≥ 38°C; +1.81; p < 0.001) or anosmia (+1.91; p < 0.001) were significantly associated with increased anti-RBD BR. Age (p = 0.85), sex (p = 0.28) and cough (p = 0.35) were not. When time since symptom onset was considered, we did not observe a significant change in anti-RBD BR (p = 0.95) but did note decreasing anti-NP BR (p < 0.001).ConclusionSARS-CoV-2 anti-RBD IgG showed significant correlation with anti-NP IgG for absolute seroconversion and BR. Higher BR were seen in symptomatic individuals, particularly those with fever. Inter-assay variability (12.5%) was evident and raises considerations for optimising seroprevalence testing strategies/studies." @default.
- W4225499430 created "2022-05-05" @default.
- W4225499430 creator A5007826002 @default.
- W4225499430 creator A5007840115 @default.
- W4225499430 creator A5011271764 @default.
- W4225499430 creator A5013261735 @default.
- W4225499430 creator A5015427212 @default.
- W4225499430 creator A5025686849 @default.
- W4225499430 creator A5035891124 @default.
- W4225499430 creator A5035894222 @default.
- W4225499430 creator A5050198943 @default.
- W4225499430 creator A5051889045 @default.
- W4225499430 creator A5053811549 @default.
- W4225499430 creator A5060261472 @default.
- W4225499430 creator A5063808747 @default.
- W4225499430 creator A5064129294 @default.
- W4225499430 creator A5065784852 @default.
- W4225499430 creator A5070312333 @default.
- W4225499430 creator A5077240637 @default.
- W4225499430 creator A5077338630 @default.
- W4225499430 date "2022-01-27" @default.
- W4225499430 modified "2023-09-26" @default.
- W4225499430 title "Variability in detection of SARS-CoV-2-specific antibody responses following mild infection: a prospective multicentre cross-sectional study, London, United Kingdom, 17 April to 17 July 2020" @default.
- W4225499430 cites W3018517500 @default.
- W4225499430 cites W3024403805 @default.
- W4225499430 cites W3024428857 @default.
- W4225499430 cites W3028715179 @default.
- W4225499430 cites W3036931136 @default.
- W4225499430 cites W3044498494 @default.
- W4225499430 cites W3045698497 @default.
- W4225499430 cites W3080689005 @default.
- W4225499430 cites W3087128437 @default.
- W4225499430 cites W3096867322 @default.
- W4225499430 cites W3117382778 @default.
- W4225499430 cites W3118375381 @default.
- W4225499430 cites W3135708297 @default.
- W4225499430 cites W3136795207 @default.
- W4225499430 cites W3165046644 @default.
- W4225499430 doi "https://doi.org/10.2807/1560-7917.es.2022.27.4.2002076" @default.
- W4225499430 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35086612" @default.
- W4225499430 hasPublicationYear "2022" @default.
- W4225499430 type Work @default.
- W4225499430 citedByCount "5" @default.
- W4225499430 countsByYear W42254994302022 @default.
- W4225499430 countsByYear W42254994302023 @default.
- W4225499430 crossrefType "journal-article" @default.
- W4225499430 hasAuthorship W4225499430A5007826002 @default.
- W4225499430 hasAuthorship W4225499430A5007840115 @default.
- W4225499430 hasAuthorship W4225499430A5011271764 @default.
- W4225499430 hasAuthorship W4225499430A5013261735 @default.
- W4225499430 hasAuthorship W4225499430A5015427212 @default.
- W4225499430 hasAuthorship W4225499430A5025686849 @default.
- W4225499430 hasAuthorship W4225499430A5035891124 @default.
- W4225499430 hasAuthorship W4225499430A5035894222 @default.
- W4225499430 hasAuthorship W4225499430A5050198943 @default.
- W4225499430 hasAuthorship W4225499430A5051889045 @default.
- W4225499430 hasAuthorship W4225499430A5053811549 @default.
- W4225499430 hasAuthorship W4225499430A5060261472 @default.
- W4225499430 hasAuthorship W4225499430A5063808747 @default.
- W4225499430 hasAuthorship W4225499430A5064129294 @default.
- W4225499430 hasAuthorship W4225499430A5065784852 @default.
- W4225499430 hasAuthorship W4225499430A5070312333 @default.
- W4225499430 hasAuthorship W4225499430A5077240637 @default.
- W4225499430 hasAuthorship W4225499430A5077338630 @default.
- W4225499430 hasBestOaLocation W42254994301 @default.
- W4225499430 hasConcept C126322002 @default.
- W4225499430 hasConcept C142052008 @default.
- W4225499430 hasConcept C142724271 @default.
- W4225499430 hasConcept C159654299 @default.
- W4225499430 hasConcept C188816634 @default.
- W4225499430 hasConcept C203014093 @default.
- W4225499430 hasConcept C2777910003 @default.
- W4225499430 hasConcept C2778494684 @default.
- W4225499430 hasConcept C44249647 @default.
- W4225499430 hasConcept C45189115 @default.
- W4225499430 hasConcept C71924100 @default.
- W4225499430 hasConcept C90924648 @default.
- W4225499430 hasConceptScore W4225499430C126322002 @default.
- W4225499430 hasConceptScore W4225499430C142052008 @default.
- W4225499430 hasConceptScore W4225499430C142724271 @default.
- W4225499430 hasConceptScore W4225499430C159654299 @default.
- W4225499430 hasConceptScore W4225499430C188816634 @default.
- W4225499430 hasConceptScore W4225499430C203014093 @default.
- W4225499430 hasConceptScore W4225499430C2777910003 @default.
- W4225499430 hasConceptScore W4225499430C2778494684 @default.
- W4225499430 hasConceptScore W4225499430C44249647 @default.
- W4225499430 hasConceptScore W4225499430C45189115 @default.
- W4225499430 hasConceptScore W4225499430C71924100 @default.
- W4225499430 hasConceptScore W4225499430C90924648 @default.
- W4225499430 hasIssue "4" @default.
- W4225499430 hasLocation W42254994301 @default.
- W4225499430 hasLocation W42254994302 @default.
- W4225499430 hasLocation W42254994303 @default.
- W4225499430 hasLocation W42254994304 @default.
- W4225499430 hasOpenAccess W4225499430 @default.
- W4225499430 hasPrimaryLocation W42254994301 @default.
- W4225499430 hasRelatedWork W1987215768 @default.
- W4225499430 hasRelatedWork W1995188757 @default.
- W4225499430 hasRelatedWork W2016679923 @default.
- W4225499430 hasRelatedWork W2114211676 @default.