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- W4225501158 abstract "Abstract Nonmelanoma skin cancer (NMSC) is the most frequently diagnosed malignancy in humans, representing a broad range of cutaneous tumors. Keratinocyte carcinomas, including basal cell carcinoma (BCC) and cutaneous squamous cell carcinoma (CSCC), are the most common NMSCs. The incidence of BCC and CSCC is steadily increasing due to a progressively aging population, chronic exposure to ultraviolet radiation, and increased awareness with earlier diagnosis. Rarer NMSCs, such as Merkel cell carcinoma (MCC) and cutaneous adnexal carcinomas, are also on the rise. Although the majority of NMSC tumors are localized at diagnosis and managed effectively with curative surgery and radiation, in rare cases with nodal and distant metastases, systemic therapy is often required. As our understanding of the immunologic characteristics of NMSCs has improved, effective treatment options have expanded with the development of immunotherapy. The FDA recently approved several immune checkpoint inhibitors for the treatment of locally advanced and metastatic MCC, CSCC, and BCC. We review the emerging role of immunotherapy as the standard of care for several advanced NMSCs not amenable to surgery and/or radiation and underscore the need for considering clinical trials of novel strategies in patients when immunotherapy does not provide durable benefit. Finally, we explore the potential of neoadjuvant and adjuvant immunotherapy." @default.
- W4225501158 created "2022-05-05" @default.
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- W4225501158 creator A5087891557 @default.
- W4225501158 creator A5090739964 @default.
- W4225501158 date "2022-02-01" @default.
- W4225501158 modified "2023-10-01" @default.
- W4225501158 title "Immunotherapy for Nonmelanoma Skin Cancer: Facts and Hopes" @default.
- W4225501158 cites W1549118871 @default.
- W4225501158 cites W1554829774 @default.
- W4225501158 cites W1557897376 @default.
- W4225501158 cites W1599260431 @default.
- W4225501158 cites W1852538637 @default.
- W4225501158 cites W1947385943 @default.
- W4225501158 cites W1968375358 @default.
- W4225501158 cites W1984816352 @default.
- W4225501158 cites W1990453562 @default.
- W4225501158 cites W2001563626 @default.
- W4225501158 cites W2001879156 @default.
- W4225501158 cites W2053909715 @default.
- W4225501158 cites W2085487956 @default.
- W4225501158 cites W2101616608 @default.
- W4225501158 cites W2106050839 @default.
- W4225501158 cites W2110884016 @default.
- W4225501158 cites W2143902340 @default.
- W4225501158 cites W2153635433 @default.
- W4225501158 cites W2155752258 @default.
- W4225501158 cites W2157466346 @default.
- W4225501158 cites W2159297424 @default.
- W4225501158 cites W2227028621 @default.
- W4225501158 cites W2279561773 @default.
- W4225501158 cites W2283046649 @default.
- W4225501158 cites W2303235652 @default.
- W4225501158 cites W2334577496 @default.
- W4225501158 cites W2339890238 @default.
- W4225501158 cites W2498543837 @default.
- W4225501158 cites W2510686645 @default.
- W4225501158 cites W2521503673 @default.
- W4225501158 cites W2526416501 @default.
- W4225501158 cites W2535269087 @default.
- W4225501158 cites W2536600071 @default.
- W4225501158 cites W2540082088 @default.
- W4225501158 cites W2578528809 @default.
- W4225501158 cites W2587048937 @default.
- W4225501158 cites W2594507808 @default.
- W4225501158 cites W2615736857 @default.
- W4225501158 cites W2626806579 @default.
- W4225501158 cites W2715923597 @default.
- W4225501158 cites W2739554663 @default.
- W4225501158 cites W2747660904 @default.
- W4225501158 cites W2766831098 @default.
- W4225501158 cites W2773106490 @default.
- W4225501158 cites W2781189224 @default.
- W4225501158 cites W2782712404 @default.
- W4225501158 cites W2784114001 @default.
- W4225501158 cites W2792186162 @default.
- W4225501158 cites W2804410820 @default.
- W4225501158 cites W2805968856 @default.
- W4225501158 cites W2808965536 @default.
- W4225501158 cites W2884610513 @default.
- W4225501158 cites W2886548594 @default.
- W4225501158 cites W2888104081 @default.
- W4225501158 cites W2890050988 @default.
- W4225501158 cites W2890384371 @default.
- W4225501158 cites W2894997912 @default.
- W4225501158 cites W2897285828 @default.
- W4225501158 cites W2901848068 @default.
- W4225501158 cites W2903317594 @default.
- W4225501158 cites W2933724412 @default.
- W4225501158 cites W2947566748 @default.
- W4225501158 cites W2949067208 @default.
- W4225501158 cites W2967623209 @default.
- W4225501158 cites W2971572325 @default.
- W4225501158 cites W2977497452 @default.
- W4225501158 cites W2995667149 @default.
- W4225501158 cites W3018248125 @default.
- W4225501158 cites W3037215952 @default.
- W4225501158 cites W3043252982 @default.
- W4225501158 cites W3046607405 @default.
- W4225501158 cites W3081857289 @default.
- W4225501158 cites W3082771926 @default.
- W4225501158 cites W3084175204 @default.
- W4225501158 cites W3085521743 @default.
- W4225501158 cites W3120517966 @default.
- W4225501158 cites W3122693774 @default.
- W4225501158 cites W3184314094 @default.
- W4225501158 cites W3211488171 @default.
- W4225501158 cites W571385461 @default.
- W4225501158 doi "https://doi.org/10.1158/1078-0432.ccr-21-2971" @default.
- W4225501158 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35121622" @default.
- W4225501158 hasPublicationYear "2022" @default.
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