Matches in SemOpenAlex for { <https://semopenalex.org/work/W4225501713> ?p ?o ?g. }
- W4225501713 abstract "Significance Cu/Zn superoxide dismutase (Sod1) is a key antioxidant enzyme, and its importance is underscored by the fact that its ablation in cell and animal models results in oxidative stress; metabolic defects; and reductions in cell proliferation, viability, and lifespan. Curiously, Sod1 detoxifies superoxide radicals (O 2 •− ) in a manner that produces an oxidant as byproduct, hydrogen peroxide (H 2 O 2 ). While much is known about the necessity of scavenging O 2 •− , it is less clear what the physiological roles of Sod1-derived H 2 O 2 are. We discovered that Sod1-derived H 2 O 2 plays an important role in antioxidant defense by stimulating the production of NADPH, a vital cellular reductant required for reactive oxygen species scavenging enzymes, as well as redox regulating a large network of enzymes." @default.
- W4225501713 created "2022-05-05" @default.
- W4225501713 creator A5028128648 @default.
- W4225501713 creator A5036862812 @default.
- W4225501713 creator A5044996344 @default.
- W4225501713 creator A5051069155 @default.
- W4225501713 creator A5060480412 @default.
- W4225501713 creator A5063459118 @default.
- W4225501713 date "2021-12-30" @default.
- W4225501713 modified "2023-10-17" @default.
- W4225501713 title "Sod1 integrates oxygen availability to redox regulate NADPH production and the thiol redoxome" @default.
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