Matches in SemOpenAlex for { <https://semopenalex.org/work/W4225510375> ?p ?o ?g. }
- W4225510375 endingPage "35" @default.
- W4225510375 startingPage "27" @default.
- W4225510375 abstract "Hemophilia A is the most common severe inherited bleeding disorder in males. Initial treatment strategies focused on the use of factor concentrates to prevent joint bleeding and the development of long-term crippling arthropathy. The current standard of care has evolved from regular replacement of factor VIII concentrates which has significantly improved the quality of life for those with severe disease to include and consider novel therapies that augment or bypass the hemostatic pathway (ie, emicizumab, Mim8). Other pipeline therapies that suppress specific natural anticoagulant pathways (ie, antithrombin, TFPI) to reestablish hemostatic balance are under Phase 3 trial investigation. These novel therapeutics have allowed providers more variety in dosing regimens and ease of administration while also maintaining effective bleeding prevention. The possibility of curative gene therapy is under exploration, with ongoing clinical trials in adult males." @default.
- W4225510375 created "2022-05-05" @default.
- W4225510375 creator A5000441991 @default.
- W4225510375 creator A5000917771 @default.
- W4225510375 creator A5076531502 @default.
- W4225510375 date "2022-02-01" @default.
- W4225510375 modified "2023-09-30" @default.
- W4225510375 title "Managing Severe Hemophilia A in Children: Pharmacotherapeutic Options" @default.
- W4225510375 cites W1586981128 @default.
- W4225510375 cites W1748661727 @default.
- W4225510375 cites W1754890660 @default.
- W4225510375 cites W1964148546 @default.
- W4225510375 cites W1965747253 @default.
- W4225510375 cites W1968700823 @default.
- W4225510375 cites W1991453997 @default.
- W4225510375 cites W2011753037 @default.
- W4225510375 cites W2020123164 @default.
- W4225510375 cites W2021197448 @default.
- W4225510375 cites W2027319450 @default.
- W4225510375 cites W2039215350 @default.
- W4225510375 cites W2098837289 @default.
- W4225510375 cites W2101694407 @default.
- W4225510375 cites W2147887043 @default.
- W4225510375 cites W2151431664 @default.
- W4225510375 cites W2167801052 @default.
- W4225510375 cites W2424921876 @default.
- W4225510375 cites W2509144358 @default.
- W4225510375 cites W2734287351 @default.
- W4225510375 cites W2765948748 @default.
- W4225510375 cites W2766748635 @default.
- W4225510375 cites W2804969681 @default.
- W4225510375 cites W2807217137 @default.
- W4225510375 cites W2888898681 @default.
- W4225510375 cites W2899883040 @default.
- W4225510375 cites W2900100541 @default.
- W4225510375 cites W2936143155 @default.
- W4225510375 cites W2953117569 @default.
- W4225510375 cites W2966032765 @default.
- W4225510375 cites W2969898037 @default.
- W4225510375 cites W2980900975 @default.
- W4225510375 cites W2982717082 @default.
- W4225510375 cites W2983057487 @default.
- W4225510375 cites W2986098563 @default.
- W4225510375 cites W2994542907 @default.
- W4225510375 cites W3007050672 @default.
- W4225510375 cites W3029999028 @default.
- W4225510375 cites W3037016973 @default.
- W4225510375 cites W3039327213 @default.
- W4225510375 cites W3047046471 @default.
- W4225510375 cites W3084060684 @default.
- W4225510375 cites W3094918774 @default.
- W4225510375 cites W3111884070 @default.
- W4225510375 cites W3112587092 @default.
- W4225510375 cites W3130275783 @default.
- W4225510375 cites W3160156269 @default.
- W4225510375 cites W3165012990 @default.
- W4225510375 cites W4238595831 @default.
- W4225510375 doi "https://doi.org/10.2147/phmt.s293246" @default.
- W4225510375 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35210899" @default.
- W4225510375 hasPublicationYear "2022" @default.
- W4225510375 type Work @default.
- W4225510375 citedByCount "5" @default.
- W4225510375 countsByYear W42255103752022 @default.
- W4225510375 countsByYear W42255103752023 @default.
- W4225510375 crossrefType "journal-article" @default.
- W4225510375 hasAuthorship W4225510375A5000441991 @default.
- W4225510375 hasAuthorship W4225510375A5000917771 @default.
- W4225510375 hasAuthorship W4225510375A5076531502 @default.
- W4225510375 hasBestOaLocation W42255103751 @default.
- W4225510375 hasConcept C126322002 @default.
- W4225510375 hasConcept C141071460 @default.
- W4225510375 hasConcept C159110408 @default.
- W4225510375 hasConcept C177713679 @default.
- W4225510375 hasConcept C187212893 @default.
- W4225510375 hasConcept C2777288759 @default.
- W4225510375 hasConcept C2777557582 @default.
- W4225510375 hasConcept C2778382381 @default.
- W4225510375 hasConcept C2778385053 @default.
- W4225510375 hasConcept C2779026020 @default.
- W4225510375 hasConcept C2779134260 @default.
- W4225510375 hasConcept C2779951463 @default.
- W4225510375 hasConcept C535046627 @default.
- W4225510375 hasConcept C71924100 @default.
- W4225510375 hasConceptScore W4225510375C126322002 @default.
- W4225510375 hasConceptScore W4225510375C141071460 @default.
- W4225510375 hasConceptScore W4225510375C159110408 @default.
- W4225510375 hasConceptScore W4225510375C177713679 @default.
- W4225510375 hasConceptScore W4225510375C187212893 @default.
- W4225510375 hasConceptScore W4225510375C2777288759 @default.
- W4225510375 hasConceptScore W4225510375C2777557582 @default.
- W4225510375 hasConceptScore W4225510375C2778382381 @default.
- W4225510375 hasConceptScore W4225510375C2778385053 @default.
- W4225510375 hasConceptScore W4225510375C2779026020 @default.
- W4225510375 hasConceptScore W4225510375C2779134260 @default.
- W4225510375 hasConceptScore W4225510375C2779951463 @default.
- W4225510375 hasConceptScore W4225510375C535046627 @default.
- W4225510375 hasConceptScore W4225510375C71924100 @default.
- W4225510375 hasLocation W42255103751 @default.