Matches in SemOpenAlex for { <https://semopenalex.org/work/W4225510399> ?p ?o ?g. }
- W4225510399 abstract "ABSTRACT Imprinting control region (ICR1) controls the expression of the Igf2 and H19 genes in a parent-of-origin specific manner. Appropriate expression of the Igf2-H19 locus is fundamental for normal fetal development, yet the importance of ICR1 in the placental production of hormones that promote maternal nutrient allocation to the fetus is unknown. To address this, we used a novel mouse model to selectively delete ICR1 in the endocrine junctional zone (Jz) of the mouse placenta (Jz-ΔICR1). The Jz-ΔICR1 mice exhibit increased Igf2 and decreased H19 expression specifically in the Jz. This was accompanied by an expansion of Jz endocrine cell types due to enhanced rates of proliferation and increased expression of pregnancy-specific glycoprotein 23 in the placenta of both fetal sexes. However, changes in the endocrine phenotype of the placenta were related to sexually-dimorphic alterations to the abundance of Igf2 receptors and downstream signalling pathways (Pi3k-Akt and Mapk). There was no effect of Jz-ΔICR1 on the expression of targets of the H19-embedded miR-675 or on fetal weight. Our results demonstrate that ICR1 controls placental endocrine capacity via sex-dependent changes in signalling." @default.
- W4225510399 created "2022-05-05" @default.
- W4225510399 creator A5017729316 @default.
- W4225510399 creator A5027953416 @default.
- W4225510399 creator A5047832487 @default.
- W4225510399 date "2022-01-01" @default.
- W4225510399 modified "2023-09-27" @default.
- W4225510399 title "Loss of imprinting of the <i>Igf2-H19</i> ICR1 enhances placental endocrine capacity via sex-specific alterations in signalling pathways in the mouse" @default.
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