Matches in SemOpenAlex for { <https://semopenalex.org/work/W4225511306> ?p ?o ?g. }
- W4225511306 abstract "The septum is a ventral forebrain structure known to regulate innate behaviors. During embryonic development, septal neurons are produced in multiple proliferative areas from neural progenitors following transcriptional programs that are still largely unknown. Here, we use a combination of single-cell RNA sequencing, histology, and genetic models to address how septal neuron diversity is established during neurogenesis. We find that the transcriptional profiles of septal progenitors change along neurogenesis, coinciding with the generation of distinct neuron types. We characterize the septal eminence, an anatomically distinct and transient proliferative zone composed of progenitors with distinctive molecular profiles, proliferative capacity, and fate potential compared to the rostral septal progenitor zone. We show that Nkx2.1 -expressing septal eminence progenitors give rise to neurons belonging to at least three morphological classes, born in temporal cohorts that are distributed across different septal nuclei in a sequential fountain-like pattern. Our study provides insight into the molecular programs that control the sequential production of different neuronal types in the septum, a structure with important roles in regulating mood and motivation." @default.
- W4225511306 created "2022-05-05" @default.
- W4225511306 creator A5011334314 @default.
- W4225511306 creator A5024278326 @default.
- W4225511306 creator A5044323545 @default.
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- W4225511306 creator A5080717862 @default.
- W4225511306 creator A5084045644 @default.
- W4225511306 date "2021-12-01" @default.
- W4225511306 modified "2023-10-16" @default.
- W4225511306 title "Transcriptional profiling of sequentially generated septal neuron fates" @default.
- W4225511306 cites W1594310190 @default.
- W4225511306 cites W1726731739 @default.
- W4225511306 cites W1861019776 @default.
- W4225511306 cites W1924943590 @default.
- W4225511306 cites W1935339094 @default.
- W4225511306 cites W1965330058 @default.
- W4225511306 cites W1977736876 @default.
- W4225511306 cites W1981590299 @default.
- W4225511306 cites W1983632203 @default.
- W4225511306 cites W1987145582 @default.
- W4225511306 cites W1989723706 @default.
- W4225511306 cites W1989768591 @default.
- W4225511306 cites W1990500865 @default.
- W4225511306 cites W1998570170 @default.
- W4225511306 cites W1998790016 @default.
- W4225511306 cites W2003774068 @default.
- W4225511306 cites W2007468095 @default.
- W4225511306 cites W2013034774 @default.
- W4225511306 cites W2025845183 @default.
- W4225511306 cites W2035487513 @default.
- W4225511306 cites W2040927571 @default.
- W4225511306 cites W2044699614 @default.
- W4225511306 cites W2046784118 @default.
- W4225511306 cites W2047936342 @default.
- W4225511306 cites W2050792240 @default.
- W4225511306 cites W2055723020 @default.
- W4225511306 cites W2059078922 @default.
- W4225511306 cites W2059216629 @default.
- W4225511306 cites W2061983672 @default.
- W4225511306 cites W2063511140 @default.
- W4225511306 cites W2067551890 @default.
- W4225511306 cites W2069089843 @default.
- W4225511306 cites W2085582971 @default.
- W4225511306 cites W2094703740 @default.
- W4225511306 cites W2098956752 @default.
- W4225511306 cites W2099988044 @default.
- W4225511306 cites W2116517439 @default.
- W4225511306 cites W2122199698 @default.
- W4225511306 cites W2122551650 @default.
- W4225511306 cites W2123491442 @default.
- W4225511306 cites W2127535417 @default.
- W4225511306 cites W2135937351 @default.
- W4225511306 cites W2139388215 @default.
- W4225511306 cites W2140536312 @default.
- W4225511306 cites W2140977742 @default.
- W4225511306 cites W2153093640 @default.
- W4225511306 cites W2157862682 @default.
- W4225511306 cites W2165130538 @default.
- W4225511306 cites W2167279371 @default.
- W4225511306 cites W2307223176 @default.
- W4225511306 cites W2519305421 @default.
- W4225511306 cites W2564176045 @default.
- W4225511306 cites W2593482707 @default.
- W4225511306 cites W2615767183 @default.
- W4225511306 cites W2734522753 @default.
- W4225511306 cites W2749159502 @default.
- W4225511306 cites W2753261993 @default.
- W4225511306 cites W2765697964 @default.
- W4225511306 cites W2767402381 @default.
- W4225511306 cites W2773035279 @default.
- W4225511306 cites W2784018756 @default.
- W4225511306 cites W2789083734 @default.
- W4225511306 cites W2791731597 @default.
- W4225511306 cites W2794480084 @default.
- W4225511306 cites W2800392236 @default.
- W4225511306 cites W2803933126 @default.
- W4225511306 cites W2897707283 @default.
- W4225511306 cites W2905501654 @default.
- W4225511306 cites W2908670724 @default.
- W4225511306 cites W2908903363 @default.
- W4225511306 cites W2944693844 @default.
- W4225511306 cites W2946389085 @default.
- W4225511306 cites W2951440899 @default.
- W4225511306 cites W2952650776 @default.
- W4225511306 cites W2964351630 @default.
- W4225511306 cites W2965664497 @default.
- W4225511306 cites W2967661967 @default.
- W4225511306 cites W2979981663 @default.
- W4225511306 cites W2996098579 @default.
- W4225511306 cites W3002219094 @default.
- W4225511306 cites W3014923780 @default.
- W4225511306 cites W3023111531 @default.
- W4225511306 cites W3048813971 @default.
- W4225511306 cites W3082326658 @default.
- W4225511306 cites W3092887357 @default.
- W4225511306 cites W3164440374 @default.