FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4225511319> ?p ?o ?g. }

• W4225511319 abstract "Astrocytes release gliotransmitters via connexin 43 (Cx43) hemichannels into neighboring synapses, which can modulate synaptic activity and are necessary for fear memory consolidation. However, the gliotransmitters released, and their mechanisms of action remain elusive. Here, we report that fear conditioning training elevated Cx43 hemichannel activity in astrocytes from the basolateral amygdala (BLA). The selective blockade of Cx43 hemichannels by microinfusion of TAT-Cx43L2 peptide into the BLA induced memory deficits 1 and 24 h after training, without affecting learning. The memory impairments were prevented by the co-injection of glutamate and D-serine, but not by the injection of either alone, suggesting a role for NMDA receptors (NMDAR). The incubation with TAT-Cx43L2 decreased NMDAR-mediated currents in BLA slices, effect that was also prevented by the addition of glutamate and D-serine. NMDARs in primary neuronal cultures were unaffected by TAT-Cx43L2, ruling out direct effects of the peptide on NMDARs. Finally, we show that D-serine permeates through purified Cx43 hemichannels reconstituted in liposomes. We propose that the release of glutamate and D-serine from astrocytes through Cx43 hemichannels is necessary for the activation of post-synaptic NMDARs during training, to allow for the formation of short-term and subsequent long-term memory, but not for learning per se." @default.
• W4225511319 created "2022-05-05" @default.
• W4225511319 creator A5001408964 @default.
• W4225511319 creator A5001535506 @default.
• W4225511319 creator A5001751719 @default.
• W4225511319 creator A5008711195 @default.
• W4225511319 creator A5009881293 @default.
• W4225511319 creator A5012430280 @default.
• W4225511319 creator A5026954687 @default.
• W4225511319 creator A5034416738 @default.
• W4225511319 creator A5036161196 @default.
• W4225511319 creator A5040362481 @default.
• W4225511319 creator A5043678915 @default.
• W4225511319 creator A5045733795 @default.
• W4225511319 creator A5046205617 @default.
• W4225511319 creator A5050682365 @default.
• W4225511319 creator A5063408324 @default.
• W4225511319 creator A5073565129 @default.
• W4225511319 creator A5076950661 @default.
• W4225511319 creator A5082507024 @default.
• W4225511319 creator A5082890671 @default.
• W4225511319 date "2022-01-21" @default.
• W4225511319 modified "2023-10-15" @default.
• W4225511319 title "Astroglial gliotransmitters released via Cx43 hemichannels regulate NMDAR‐dependent transmission and short‐term fear memory in the basolateral amygdala" @default.
• W4225511319 cites W1487875522 @default.
• W4225511319 cites W1533562283 @default.
• W4225511319 cites W1618945825 @default.
• W4225511319 cites W1820680165 @default.
• W4225511319 cites W1959664337 @default.
• W4225511319 cites W1964092917 @default.
• W4225511319 cites W1969183124 @default.
• W4225511319 cites W1969191149 @default.
• W4225511319 cites W1970612448 @default.
• W4225511319 cites W1971080136 @default.
• W4225511319 cites W1972107534 @default.
• W4225511319 cites W1979044083 @default.
• W4225511319 cites W1981893433 @default.
• W4225511319 cites W1983376840 @default.
• W4225511319 cites W1984360952 @default.
• W4225511319 cites W1985607929 @default.
• W4225511319 cites W1991517801 @default.
• W4225511319 cites W1994757585 @default.
• W4225511319 cites W1998047506 @default.
• W4225511319 cites W1998432972 @default.
• W4225511319 cites W2001725826 @default.
• W4225511319 cites W2005813396 @default.
• W4225511319 cites W2013582450 @default.
• W4225511319 cites W2013752437 @default.
• W4225511319 cites W2014556905 @default.
• W4225511319 cites W2017340012 @default.
• W4225511319 cites W2017523469 @default.
• W4225511319 cites W2017932377 @default.
• W4225511319 cites W2022767998 @default.
• W4225511319 cites W2028836570 @default.
• W4225511319 cites W2033794046 @default.
• W4225511319 cites W2036796078 @default.
• W4225511319 cites W2040128952 @default.
• W4225511319 cites W2041874445 @default.
• W4225511319 cites W2045092834 @default.
• W4225511319 cites W2048105028 @default.
• W4225511319 cites W2048201004 @default.
• W4225511319 cites W2049407768 @default.
• W4225511319 cites W2055652253 @default.
• W4225511319 cites W2079311820 @default.
• W4225511319 cites W2085123274 @default.
• W4225511319 cites W2085503883 @default.
• W4225511319 cites W2095231337 @default.
• W4225511319 cites W2101299206 @default.
• W4225511319 cites W2104357869 @default.
• W4225511319 cites W2104417933 @default.
• W4225511319 cites W2109909801 @default.
• W4225511319 cites W2111970188 @default.
• W4225511319 cites W2120714098 @default.
• W4225511319 cites W2124017577 @default.
• W4225511319 cites W2126320773 @default.
• W4225511319 cites W2126643175 @default.
• W4225511319 cites W2129511422 @default.
• W4225511319 cites W2134046709 @default.
• W4225511319 cites W2138670140 @default.
• W4225511319 cites W2139817708 @default.
• W4225511319 cites W2146581722 @default.
• W4225511319 cites W2154262751 @default.
• W4225511319 cites W2156726790 @default.
• W4225511319 cites W2159029858 @default.
• W4225511319 cites W2161453950 @default.
• W4225511319 cites W2164370979 @default.
• W4225511319 cites W2166440827 @default.
• W4225511319 cites W2171863507 @default.
• W4225511319 cites W2534023149 @default.
• W4225511319 cites W2744137535 @default.
• W4225511319 cites W4233643243 @default.
• W4225511319 cites W4238550549 @default.
• W4225511319 cites W4245129714 @default.
• W4225511319 doi "https://doi.org/10.1096/fj.202100798rr" @default.
• W4225511319 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35061296" @default.
• W4225511319 hasPublicationYear "2022" @default.
• W4225511319 type Work @default.
• W4225511319 citedByCount "10" @default.
• W4225511319 countsByYear W42255113192022 @default.
• W4225511319 countsByYear W42255113192023 @default.

• next