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- W4225511328 abstract "Selective IgM deficiency (SIgMD) has been described for more than 50 years; however, it is only recently being incorporated in IUIS classification of “Inborn Errors of Immunity.” It appears to be more common than previously recognized. The genetic basis of SIgMD remains unclear. Although symptomatic patients commonly present with infectious manifestations, autoimmune diseases are present in more than one-third of patients. In this chapter, we have reviewed the characteristics of natural IgM and its role in autoimmunity exemplified in murine model of autoimmune diseases and in mice deficient in secreted IgM and FcμR. Finally, we have reviewed autoimmunity and autoimmune diseases in patients with SIgMD. Various mechanisms for autoimmunity in SIgMD are discussed." @default.
- W4225511328 created "2022-05-05" @default.
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- W4225511328 date "2022-01-01" @default.
- W4225511328 modified "2023-10-14" @default.
- W4225511328 title "Autoimmunity and autoimmune diseases in primary selective IgM deficiency" @default.
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- W4225511328 doi "https://doi.org/10.1016/b978-0-323-85415-3.00010-6" @default.
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