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• W4225514507 abstract "This study is to uncover the possibilities of CCL20 and IL-17A to be potential hallmarks for laryngeal carcinoma. Relative levels of CCL20 and IL-17A in laryngeal carcinoma tissues were detected by quantitative real-time polymerase chain reaction (qRT-PCR). Correlation between CCL20 and IL-17A was analyzed by Pearson correlation test. Receiver operating characteristic (ROC) curves were depicted for assessing diagnostic values of CCL20 and IL-17A in laryngeal carcinoma. In addition, 98 laryngeal carcinoma patients were followed up for 5 years. Their follow-up data were utilized for assessing prognostic values of CCL20 and IL-17A. CCL20 and IL-17A were upregulated in laryngeal carcinoma tissues than those of normal ones. ROC curves identified diagnostic values of CCL20 ( <math xmlns=http://www.w3.org/1998/Math/MathML id=M1> <mtext>AUC</mtext> <mo>=</mo> <mn>0.9719</mn> </math> , <math xmlns=http://www.w3.org/1998/Math/MathML id=M2> <mtext>cutoff</mtext> <mtext> </mtext> <mtext>value</mtext> <mo>=</mo> <mn>4.86</mn> </math> , <math xmlns=http://www.w3.org/1998/Math/MathML id=M3> <mtext>sensitivity</mtext> <mo>=</mo> <mn>98.98</mn> <mi>%</mi> </math> , <math xmlns=http://www.w3.org/1998/Math/MathML id=M4> <mtext>specificity</mtext> <mo>=</mo> <mn>87.76</mn> <mi>%</mi> </math> ) and IL-17A ( <math xmlns=http://www.w3.org/1998/Math/MathML id=M5> <mtext>AUC</mtext> <mo>=</mo> <mn>0.7965</mn> </math> , <math xmlns=http://www.w3.org/1998/Math/MathML id=M6> <mtext>cutoff</mtext> <mtext> </mtext> <mtext>value</mtext> <mo>=</mo> <mn>3.39</mn> </math> , <math xmlns=http://www.w3.org/1998/Math/MathML id=M7> <mtext>sensitivity</mtext> <mo>=</mo> <mn>71.31</mn> <mi>%</mi> </math> , <math xmlns=http://www.w3.org/1998/Math/MathML id=M8> <mtext>specificity</mtext> <mo>=</mo> <mn>71.52</mn> <mi>%</mi> </math> ) in laryngeal carcinoma. Worse prognosis was observed in laryngeal carcinoma patients expressing high level of CCL20 or IL-17A. CCL20 and IL-17A are upregulated in laryngeal carcinoma tissues, which are unfavorable factors for the prognosis of laryngeal carcinoma. CCL20 and IL-17A are promising hallmarks of laryngeal carcinoma." @default.
• W4225514507 created "2022-05-05" @default.
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• W4225514507 date "2022-04-04" @default.
• W4225514507 modified "2023-10-14" @default.
• W4225514507 title "Two Potential Biomarkers for the Diagnosis and Prognosis of Laryngeal Carcinoma: CCL20 and IL-17A" @default.
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• W4225514507 doi "https://doi.org/10.1155/2022/2148240" @default.
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