Matches in SemOpenAlex for { <https://semopenalex.org/work/W4225515694> ?p ?o ?g. }
- W4225515694 endingPage "522" @default.
- W4225515694 startingPage "517" @default.
- W4225515694 abstract "The aim of the study was in-silico drug-likeness analysis, absorption, distribution, metabolism, and excretion (ADME) properties, and molecular docking studies of anthocyanins as natural anticancer compounds against acting receptor-like kinase 5 (ALK5) receptor. Transforming growth factor-β (TGF-β) plays an essential role in various cellular processes. Increased expression of TGF-β and its receptor TGFβR-I (i.e. ALK5) have been associated with poor prognosis in cancer patients.The drug-likeness activity of anthocyanins was performed using SwissADME tool. Molecular docking studies were carried out by using the Autodock Vina 1.5.6 tool.The results revealed that cyanidin-3-arabinoside (C3A), pelargonidin-3-glucoside (P3G), and peonidin-3-arabinoside (P3A) were able to use both Lipinski's rule of five and Ghose variations. The binding energies of C3A, P3G, and P3A against ALK5 were found as -8.0, -8.3, and -8.4 kcal mol-1, respectively.These selected anthocyanins have shown higher binding energies than known inhibitors to the ALK5 receptor. Further in-vitro and in-vivo studies were strongly recommended to clarify the whole mechanism." @default.
- W4225515694 created "2022-05-05" @default.
- W4225515694 creator A5018975675 @default.
- W4225515694 creator A5021188960 @default.
- W4225515694 creator A5054834217 @default.
- W4225515694 creator A5088944692 @default.
- W4225515694 date "2022-03-23" @default.
- W4225515694 modified "2023-10-03" @default.
- W4225515694 title "In-silico drug-likeness analysis, ADME properties, and molecular docking studies of cyanidin-3-arabinoside, pelargonidin-3-glucoside, and peonidin-3-arabinoside as natural anticancer compounds against acting receptor-like kinase 5 receptor" @default.
- W4225515694 cites W1970244678 @default.
- W4225515694 cites W1981737096 @default.
- W4225515694 cites W1995629953 @default.
- W4225515694 cites W2005983388 @default.
- W4225515694 cites W2027860197 @default.
- W4225515694 cites W2052147002 @default.
- W4225515694 cites W2129971112 @default.
- W4225515694 cites W2402258526 @default.
- W4225515694 cites W2466225158 @default.
- W4225515694 cites W2484335322 @default.
- W4225515694 cites W2500192509 @default.
- W4225515694 cites W2560689174 @default.
- W4225515694 cites W2570763587 @default.
- W4225515694 cites W2574998181 @default.
- W4225515694 cites W2593436234 @default.
- W4225515694 cites W2615920181 @default.
- W4225515694 cites W2739223637 @default.
- W4225515694 cites W2769775214 @default.
- W4225515694 cites W2794200039 @default.
- W4225515694 cites W2802519389 @default.
- W4225515694 cites W2803256996 @default.
- W4225515694 cites W2804413587 @default.
- W4225515694 cites W2891497275 @default.
- W4225515694 cites W2927107056 @default.
- W4225515694 cites W2944958138 @default.
- W4225515694 cites W2946514032 @default.
- W4225515694 cites W2948368848 @default.
- W4225515694 cites W2963957709 @default.
- W4225515694 cites W2988139573 @default.
- W4225515694 cites W3012775092 @default.
- W4225515694 cites W3111878160 @default.
- W4225515694 cites W3119952098 @default.
- W4225515694 cites W4235779303 @default.
- W4225515694 doi "https://doi.org/10.1097/cad.0000000000001297" @default.
- W4225515694 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35324525" @default.
- W4225515694 hasPublicationYear "2022" @default.
- W4225515694 type Work @default.
- W4225515694 citedByCount "3" @default.
- W4225515694 countsByYear W42255156942022 @default.
- W4225515694 countsByYear W42255156942023 @default.
- W4225515694 crossrefType "journal-article" @default.
- W4225515694 hasAuthorship W4225515694A5018975675 @default.
- W4225515694 hasAuthorship W4225515694A5021188960 @default.
- W4225515694 hasAuthorship W4225515694A5054834217 @default.
- W4225515694 hasAuthorship W4225515694A5088944692 @default.
- W4225515694 hasConcept C104317684 @default.
- W4225515694 hasConcept C159110408 @default.
- W4225515694 hasConcept C185592680 @default.
- W4225515694 hasConcept C2775867527 @default.
- W4225515694 hasConcept C2775905019 @default.
- W4225515694 hasConcept C2777667348 @default.
- W4225515694 hasConcept C2778004101 @default.
- W4225515694 hasConcept C2780035454 @default.
- W4225515694 hasConcept C2780152424 @default.
- W4225515694 hasConcept C41685203 @default.
- W4225515694 hasConcept C55493867 @default.
- W4225515694 hasConcept C69366308 @default.
- W4225515694 hasConcept C71924100 @default.
- W4225515694 hasConcept C86803240 @default.
- W4225515694 hasConcept C98274493 @default.
- W4225515694 hasConceptScore W4225515694C104317684 @default.
- W4225515694 hasConceptScore W4225515694C159110408 @default.
- W4225515694 hasConceptScore W4225515694C185592680 @default.
- W4225515694 hasConceptScore W4225515694C2775867527 @default.
- W4225515694 hasConceptScore W4225515694C2775905019 @default.
- W4225515694 hasConceptScore W4225515694C2777667348 @default.
- W4225515694 hasConceptScore W4225515694C2778004101 @default.
- W4225515694 hasConceptScore W4225515694C2780035454 @default.
- W4225515694 hasConceptScore W4225515694C2780152424 @default.
- W4225515694 hasConceptScore W4225515694C41685203 @default.
- W4225515694 hasConceptScore W4225515694C55493867 @default.
- W4225515694 hasConceptScore W4225515694C69366308 @default.
- W4225515694 hasConceptScore W4225515694C71924100 @default.
- W4225515694 hasConceptScore W4225515694C86803240 @default.
- W4225515694 hasConceptScore W4225515694C98274493 @default.
- W4225515694 hasIssue "6" @default.
- W4225515694 hasLocation W42255156941 @default.
- W4225515694 hasLocation W42255156942 @default.
- W4225515694 hasOpenAccess W4225515694 @default.
- W4225515694 hasPrimaryLocation W42255156941 @default.
- W4225515694 hasRelatedWork W1523599547 @default.
- W4225515694 hasRelatedWork W188266097 @default.
- W4225515694 hasRelatedWork W2062202134 @default.
- W4225515694 hasRelatedWork W2100517305 @default.
- W4225515694 hasRelatedWork W2912068866 @default.
- W4225515694 hasRelatedWork W2964783067 @default.
- W4225515694 hasRelatedWork W3113194108 @default.
- W4225515694 hasRelatedWork W4206031164 @default.
- W4225515694 hasRelatedWork W4225515694 @default.