FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4225517610> ?p ?o ?g. }

• W4225517610 abstract "The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase that couples the binding of extracellular ligands, such as EGF and transforming growth factor-α (TGF-α), to the initiation of intracellular signaling pathways. EGFR binds to EGF and TGF-α with similar affinity, but generates different signals from these ligands. To address the mechanistic basis of this phenomenon, we have carried out cryo-EM analyses of human EGFR bound to EGF and TGF-α. We show that the extracellular module adopts an ensemble of dimeric conformations when bound to either EGF or TGF-α. The two extreme states of this ensemble represent distinct ligand-bound quaternary structures in which the membrane-proximal tips of the extracellular module are either juxtaposed or separated. EGF and TGF-α differ in their ability to maintain the conformation with the membrane-proximal tips of the extracellular module separated, and this conformation is stabilized preferentially by an oncogenic EGFR mutation. Close proximity of the transmembrane helices at the junction with the extracellular module has been associated previously with increased EGFR activity. Our results show how EGFR can couple the binding of different ligands to differential modulation of this proximity, thereby suggesting a molecular mechanism for the generation of ligand-sensitive differential outputs in this receptor family." @default.
• W4225517610 created "2022-05-05" @default.
• W4225517610 creator A5002017099 @default.
• W4225517610 creator A5024897051 @default.
• W4225517610 creator A5038330393 @default.
• W4225517610 creator A5042412445 @default.
• W4225517610 creator A5064098271 @default.
• W4225517610 creator A5074255209 @default.
• W4225517610 creator A5083663702 @default.
• W4225517610 date "2021-11-30" @default.
• W4225517610 modified "2023-10-18" @default.
• W4225517610 title "A molecular mechanism for the generation of ligand-dependent differential outputs by the epidermal growth factor receptor" @default.
• W4225517610 cites W1583107506 @default.
• W4225517610 cites W1598629441 @default.
• W4225517610 cites W1966658428 @default.
• W4225517610 cites W1968324646 @default.
• W4225517610 cites W1972758026 @default.
• W4225517610 cites W1981713077 @default.
• W4225517610 cites W1990771438 @default.
• W4225517610 cites W1993177346 @default.
• W4225517610 cites W1997394451 @default.
• W4225517610 cites W2000489928 @default.
• W4225517610 cites W2010030578 @default.
• W4225517610 cites W2016655288 @default.
• W4225517610 cites W2016675163 @default.
• W4225517610 cites W2021520922 @default.
• W4225517610 cites W2028470175 @default.
• W4225517610 cites W2029667189 @default.
• W4225517610 cites W2030696041 @default.
• W4225517610 cites W2035035273 @default.
• W4225517610 cites W2036907315 @default.
• W4225517610 cites W2037690883 @default.
• W4225517610 cites W2038670745 @default.
• W4225517610 cites W2038733101 @default.
• W4225517610 cites W2038758364 @default.
• W4225517610 cites W2050165926 @default.
• W4225517610 cites W2052705131 @default.
• W4225517610 cites W2052745304 @default.
• W4225517610 cites W2056713455 @default.
• W4225517610 cites W2058620780 @default.
• W4225517610 cites W2058971275 @default.
• W4225517610 cites W2059715478 @default.
• W4225517610 cites W2061108756 @default.
• W4225517610 cites W2067174909 @default.
• W4225517610 cites W2073949924 @default.
• W4225517610 cites W2075559535 @default.
• W4225517610 cites W2076449818 @default.
• W4225517610 cites W2083831897 @default.
• W4225517610 cites W2088388211 @default.
• W4225517610 cites W2093036951 @default.
• W4225517610 cites W2099203391 @default.
• W4225517610 cites W2100794900 @default.
• W4225517610 cites W2106140689 @default.
• W4225517610 cites W2112154906 @default.
• W4225517610 cites W2121467196 @default.
• W4225517610 cites W2121805508 @default.
• W4225517610 cites W2124026197 @default.
• W4225517610 cites W2129766170 @default.
• W4225517610 cites W2132629607 @default.
• W4225517610 cites W2136343696 @default.
• W4225517610 cites W2137480570 @default.
• W4225517610 cites W2141167338 @default.
• W4225517610 cites W2148085578 @default.
• W4225517610 cites W2150981663 @default.
• W4225517610 cites W2161661741 @default.
• W4225517610 cites W2281972632 @default.
• W4225517610 cites W2295512811 @default.
• W4225517610 cites W2418963568 @default.
• W4225517610 cites W2511292374 @default.
• W4225517610 cites W2555870966 @default.
• W4225517610 cites W2587625522 @default.
• W4225517610 cites W2593511418 @default.
• W4225517610 cites W2596558690 @default.
• W4225517610 cites W2763136348 @default.
• W4225517610 cites W2786390877 @default.
• W4225517610 cites W2801604220 @default.
• W4225517610 cites W2885066448 @default.
• W4225517610 cites W2898351957 @default.
• W4225517610 cites W2899714098 @default.
• W4225517610 cites W2969354416 @default.
• W4225517610 cites W2973457155 @default.
• W4225517610 cites W2979321463 @default.
• W4225517610 cites W2995679987 @default.
• W4225517610 cites W3009387622 @default.
• W4225517610 cites W3010484781 @default.
• W4225517610 cites W3015415776 @default.
• W4225517610 cites W3044899207 @default.
• W4225517610 cites W3094005698 @default.
• W4225517610 cites W3194442817 @default.
• W4225517610 cites W3212563086 @default.
• W4225517610 doi "https://doi.org/10.7554/elife.73218" @default.
• W4225517610 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34846302" @default.
• W4225517610 hasPublicationYear "2021" @default.
• W4225517610 type Work @default.
• W4225517610 citedByCount "34" @default.
• W4225517610 countsByYear W42255176102022 @default.
• W4225517610 countsByYear W42255176102023 @default.
• W4225517610 crossrefType "journal-article" @default.
• W4225517610 hasAuthorship W4225517610A5002017099 @default.
• W4225517610 hasAuthorship W4225517610A5024897051 @default.

• next