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• W4225522877 abstract "Abstract Background While multiple cardiovascular magnetic resonance (CMR) methods provide excellent reproducibility of global circumferential and global longitudinal strain, achieving highly reproducible segmental strain is more challenging. Previous single-center studies have demonstrated excellent reproducibility of displacement encoding with stimulated echoes (DENSE) segmental circumferential strain. The present study evaluated the reproducibility of DENSE for measurement of whole-slice or global circumferential (E cc ), longitudinal (E ll ) and radial (E rr ) strain, torsion, and segmental E cc at multiple centers. Methods Six centers participated and a total of 81 subjects were studied, including 60 healthy subjects and 21 patients with various types of heart disease. CMR utilized 3 T scanners, and cine DENSE images were acquired in three short-axis planes and in the four-chamber long-axis view. During one imaging session, each subject underwent two separate DENSE scans to assess inter-scan reproducibility. Each subject was taken out of the scanner and repositioned between the scans. Intra-user, inter-user-same-site, inter-user-different-site, and inter-user-Human-Deep-Learning (DL) comparisons assessed the reproducibility of different users analyzing the same data. Inter-scan comparisons assessed the reproducibility of DENSE from scan to scan. The reproducibility of whole-slice or global E cc , E ll and E rr , torsion, and segmental E cc were quantified using Bland–Altman analysis, the coefficient of variation (CV), and the intraclass correlation coefficient (ICC). CV was considered excellent for CV ≤ 10%, good for 10% < CV ≤ 20%, fair for 20% < CV ≤ 40%, and poor for CV > 40. ICC values were considered excellent for ICC > 0.74, good for ICC 0.6 < ICC ≤ 0.74, fair for ICC 0.4 < ICC ≤ 0.59, poor for ICC < 0.4. Results Based on CV and ICC, segmental E cc provided excellent intra-user, inter-user-same-site, inter-user-different-site, inter-user-Human-DL reproducibility and good–excellent inter-scan reproducibility. Whole-slice E cc and global E ll provided excellent intra-user, inter-user-same-site, inter-user-different-site, inter-user-Human-DL and inter-scan reproducibility. The reproducibility of torsion was good–excellent for all comparisons. For whole-slice E rr , CV was in the fair-good range, and ICC was in the good–excellent range. Conclusions Multicenter data show that 3 T CMR DENSE provides highly reproducible whole-slice and segmental E cc , global E ll , and torsion measurements in healthy subjects and heart disease patients." @default.
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• W4225522877 date "2022-04-04" @default.
• W4225522877 modified "2023-10-14" @default.
• W4225522877 title "Reproducibility of global and segmental myocardial strain using cine DENSE at 3 T: a multicenter cardiovascular magnetic resonance study in healthy subjects and patients with heart disease" @default.
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• W4225522877 doi "https://doi.org/10.1186/s12968-022-00851-7" @default.
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