Matches in SemOpenAlex for { <https://semopenalex.org/work/W4225524807> ?p ?o ?g. }
- W4225524807 endingPage "385" @default.
- W4225524807 startingPage "378" @default.
- W4225524807 abstract "Pepducins are small-lipidated peptides designed from the intracellular loops of G protein-coupled receptors (GPCRs) that act in an allosteric manner to modulate the activity of GPCRs. Over the past 2 decades, pepducins have progressed initially from pharmacologic tools used to manipulate GPCR activity in an orthosteric site-independent manner to compounds with therapeutic potential that have even been used safely in phase 1 and 2 clinical trials in human subjects. The effect of pepducins at their cognate receptors has been shown to vary between antagonist, partial agonist, and biased agonist outcomes in various primary and clonal cell systems, with even small changes in amino acid sequence altering these properties and their receptor selectivity. To date, pepducins designed from numerous GPCRs have been studied for their impact on pathologic conditions, including cardiovascular diseases such as thrombosis, myocardial infarction, and atherosclerosis. This review will focus in particular on pepducins designed from protease-activated receptors, C-X-C motif chemokine receptors, formyl peptide receptors, and the β2-adrenergic receptor. We will discuss the historic context of pepducin development for each receptor, as well as the structural, signaling, pathophysiologic consequences, and therapeutic potential for each pepducin class." @default.
- W4225524807 created "2022-05-05" @default.
- W4225524807 creator A5059140156 @default.
- W4225524807 creator A5066173797 @default.
- W4225524807 date "2022-09-01" @default.
- W4225524807 modified "2023-09-26" @default.
- W4225524807 title "Pepducin-mediated G Protein-Coupled Receptor Signaling in the Cardiovascular System" @default.
- W4225524807 cites W1543599483 @default.
- W4225524807 cites W1965192419 @default.
- W4225524807 cites W1965785564 @default.
- W4225524807 cites W1966538694 @default.
- W4225524807 cites W1979789955 @default.
- W4225524807 cites W1991016702 @default.
- W4225524807 cites W2004625863 @default.
- W4225524807 cites W2010739774 @default.
- W4225524807 cites W2022946791 @default.
- W4225524807 cites W2033993593 @default.
- W4225524807 cites W2036487194 @default.
- W4225524807 cites W2042355069 @default.
- W4225524807 cites W2043395175 @default.
- W4225524807 cites W2049780044 @default.
- W4225524807 cites W2063504313 @default.
- W4225524807 cites W2064024382 @default.
- W4225524807 cites W2064634578 @default.
- W4225524807 cites W2066693617 @default.
- W4225524807 cites W2067856993 @default.
- W4225524807 cites W2070493428 @default.
- W4225524807 cites W2071496612 @default.
- W4225524807 cites W2071858539 @default.
- W4225524807 cites W2088500273 @default.
- W4225524807 cites W2089357523 @default.
- W4225524807 cites W2098052935 @default.
- W4225524807 cites W2098203510 @default.
- W4225524807 cites W2107492651 @default.
- W4225524807 cites W2119065663 @default.
- W4225524807 cites W2125221243 @default.
- W4225524807 cites W2125884418 @default.
- W4225524807 cites W2152201554 @default.
- W4225524807 cites W2152753061 @default.
- W4225524807 cites W2161939173 @default.
- W4225524807 cites W2163371429 @default.
- W4225524807 cites W2163946154 @default.
- W4225524807 cites W2164596117 @default.
- W4225524807 cites W2166999542 @default.
- W4225524807 cites W2179024575 @default.
- W4225524807 cites W2204048255 @default.
- W4225524807 cites W2256495978 @default.
- W4225524807 cites W2298398213 @default.
- W4225524807 cites W2331939040 @default.
- W4225524807 cites W2416684343 @default.
- W4225524807 cites W2418369814 @default.
- W4225524807 cites W2468767034 @default.
- W4225524807 cites W2472492028 @default.
- W4225524807 cites W2512890504 @default.
- W4225524807 cites W2562851130 @default.
- W4225524807 cites W2572582369 @default.
- W4225524807 cites W2597463553 @default.
- W4225524807 cites W2751634210 @default.
- W4225524807 cites W2760130854 @default.
- W4225524807 cites W2765153686 @default.
- W4225524807 cites W2768265518 @default.
- W4225524807 cites W2782382515 @default.
- W4225524807 cites W2795702735 @default.
- W4225524807 cites W2890775336 @default.
- W4225524807 cites W2893845410 @default.
- W4225524807 cites W2903981328 @default.
- W4225524807 cites W2906670900 @default.
- W4225524807 cites W2913837244 @default.
- W4225524807 cites W2923681300 @default.
- W4225524807 cites W2924369819 @default.
- W4225524807 cites W2958801969 @default.
- W4225524807 cites W3001511900 @default.
- W4225524807 cites W3010626959 @default.
- W4225524807 cites W3010924801 @default.
- W4225524807 cites W3070105802 @default.
- W4225524807 cites W3092185928 @default.
- W4225524807 cites W3136349003 @default.
- W4225524807 cites W3136792458 @default.
- W4225524807 cites W3191569443 @default.
- W4225524807 cites W574199841 @default.
- W4225524807 doi "https://doi.org/10.1097/fjc.0000000000001236" @default.
- W4225524807 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35170495" @default.
- W4225524807 hasPublicationYear "2022" @default.
- W4225524807 type Work @default.
- W4225524807 citedByCount "2" @default.
- W4225524807 countsByYear W42255248072022 @default.
- W4225524807 countsByYear W42255248072023 @default.
- W4225524807 crossrefType "journal-article" @default.
- W4225524807 hasAuthorship W4225524807A5059140156 @default.
- W4225524807 hasAuthorship W4225524807A5066173797 @default.
- W4225524807 hasConcept C12823836 @default.
- W4225524807 hasConcept C13373296 @default.
- W4225524807 hasConcept C135285700 @default.
- W4225524807 hasConcept C151730666 @default.
- W4225524807 hasConcept C166342909 @default.
- W4225524807 hasConcept C169760540 @default.
- W4225524807 hasConcept C170493617 @default.
- W4225524807 hasConcept C26702167 @default.