Matches in SemOpenAlex for { <https://semopenalex.org/work/W4225526175> ?p ?o ?g. }
- W4225526175 endingPage "e1142" @default.
- W4225526175 startingPage "e1142" @default.
- W4225526175 abstract "Demyelinating diseases in the CNS are characterized by myelin sheath destruction or formation disorder that leads to severe neurologic dysfunction. Remission of such diseases is largely dependent on the differentiation of oligodendrocytes precursor cells (OPCs) into mature myelin-forming OLGs at the demyelinated lesions, which is defined as remyelination. We discover that baicalin (BA), a natural flavonoid, in addition to its well-known antiinflammatory effects, directly stimulates OLG maturation and CNS myelin repair.To investigate the function of BA on CNS remyelination, we develop the complementary in vivo and in vitro models, including physiologic neonatal mouse CNS myelinogenesis model, pathologic cuprizone-induced (CPZ-induced) toxic demyelination model, and postnatal OLG maturation assay. Furthermore, molecular docking, pharmacologic regulation, and transgenic heterozygous mice were used to clarify the target and action of the mechanism of BA on myelin repair promotion.Administration of BA was not only merely effectively enhanced CNS myelinogenesis during postnatal development but also promoted remyelination and reversed the coordination movement disorder in the CPZ-induced toxic demyelination model. Of note, myelin-promoting effects of BA on myelination or regeneration is peroxisome proliferator-activated receptor γ (PPARγ) signaling-dependent.Our work demonstrated that BA promotes myelin production and regeneration by activating the PPARγ signal pathway and also confirmed that BA is an effective natural product for the treatment of demyelinating diseases." @default.
- W4225526175 created "2022-05-05" @default.
- W4225526175 creator A5007128131 @default.
- W4225526175 creator A5007580257 @default.
- W4225526175 creator A5029320730 @default.
- W4225526175 creator A5038393529 @default.
- W4225526175 creator A5039932059 @default.
- W4225526175 creator A5070604180 @default.
- W4225526175 creator A5074313769 @default.
- W4225526175 creator A5081302028 @default.
- W4225526175 creator A5082900700 @default.
- W4225526175 creator A5086218944 @default.
- W4225526175 date "2022-02-01" @default.
- W4225526175 modified "2023-10-01" @default.
- W4225526175 title "Baicalin Promotes CNS Remyelination via PPARγ Signal Pathway" @default.
- W4225526175 cites W1500846264 @default.
- W4225526175 cites W1578833500 @default.
- W4225526175 cites W1830061364 @default.
- W4225526175 cites W1963993567 @default.
- W4225526175 cites W1985664608 @default.
- W4225526175 cites W1985845421 @default.
- W4225526175 cites W1991883207 @default.
- W4225526175 cites W2009262198 @default.
- W4225526175 cites W2016457100 @default.
- W4225526175 cites W2024405339 @default.
- W4225526175 cites W2026547662 @default.
- W4225526175 cites W2036189332 @default.
- W4225526175 cites W2044216636 @default.
- W4225526175 cites W2048082433 @default.
- W4225526175 cites W2050371424 @default.
- W4225526175 cites W2056677926 @default.
- W4225526175 cites W2064558921 @default.
- W4225526175 cites W2080005589 @default.
- W4225526175 cites W2099847273 @default.
- W4225526175 cites W2122270356 @default.
- W4225526175 cites W2123311421 @default.
- W4225526175 cites W2124233214 @default.
- W4225526175 cites W2148262706 @default.
- W4225526175 cites W2149636184 @default.
- W4225526175 cites W2167876561 @default.
- W4225526175 cites W2295979384 @default.
- W4225526175 cites W2420824370 @default.
- W4225526175 cites W2606911774 @default.
- W4225526175 cites W2618434404 @default.
- W4225526175 cites W2754482261 @default.
- W4225526175 cites W2760984022 @default.
- W4225526175 cites W2761517608 @default.
- W4225526175 cites W2808266097 @default.
- W4225526175 cites W2913848851 @default.
- W4225526175 cites W3005119588 @default.
- W4225526175 cites W3014367325 @default.
- W4225526175 cites W3047618826 @default.
- W4225526175 cites W3117407786 @default.
- W4225526175 cites W3169884592 @default.
- W4225526175 cites W3172603947 @default.
- W4225526175 doi "https://doi.org/10.1212/nxi.0000000000001142" @default.
- W4225526175 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35105686" @default.
- W4225526175 hasPublicationYear "2022" @default.
- W4225526175 type Work @default.
- W4225526175 citedByCount "10" @default.
- W4225526175 countsByYear W42255261752022 @default.
- W4225526175 countsByYear W42255261752023 @default.
- W4225526175 crossrefType "journal-article" @default.
- W4225526175 hasAuthorship W4225526175A5007128131 @default.
- W4225526175 hasAuthorship W4225526175A5007580257 @default.
- W4225526175 hasAuthorship W4225526175A5029320730 @default.
- W4225526175 hasAuthorship W4225526175A5038393529 @default.
- W4225526175 hasAuthorship W4225526175A5039932059 @default.
- W4225526175 hasAuthorship W4225526175A5070604180 @default.
- W4225526175 hasAuthorship W4225526175A5074313769 @default.
- W4225526175 hasAuthorship W4225526175A5081302028 @default.
- W4225526175 hasAuthorship W4225526175A5082900700 @default.
- W4225526175 hasAuthorship W4225526175A5086218944 @default.
- W4225526175 hasBestOaLocation W42255261751 @default.
- W4225526175 hasConcept C126322002 @default.
- W4225526175 hasConcept C169760540 @default.
- W4225526175 hasConcept C203014093 @default.
- W4225526175 hasConcept C2776985911 @default.
- W4225526175 hasConcept C2777619251 @default.
- W4225526175 hasConcept C2778609137 @default.
- W4225526175 hasConcept C2780064007 @default.
- W4225526175 hasConcept C2780640218 @default.
- W4225526175 hasConcept C502942594 @default.
- W4225526175 hasConcept C529278444 @default.
- W4225526175 hasConcept C71924100 @default.
- W4225526175 hasConcept C86803240 @default.
- W4225526175 hasConcept C95444343 @default.
- W4225526175 hasConcept C98274493 @default.
- W4225526175 hasConceptScore W4225526175C126322002 @default.
- W4225526175 hasConceptScore W4225526175C169760540 @default.
- W4225526175 hasConceptScore W4225526175C203014093 @default.
- W4225526175 hasConceptScore W4225526175C2776985911 @default.
- W4225526175 hasConceptScore W4225526175C2777619251 @default.
- W4225526175 hasConceptScore W4225526175C2778609137 @default.
- W4225526175 hasConceptScore W4225526175C2780064007 @default.
- W4225526175 hasConceptScore W4225526175C2780640218 @default.
- W4225526175 hasConceptScore W4225526175C502942594 @default.
- W4225526175 hasConceptScore W4225526175C529278444 @default.